Birthweight of IVF children is still a current issue and still related to maternal factors

Anzola, Any Beltran; Pauly, Vanessa; Rivière, Olivier; Sambuc, Roland; Boyer, Pierre; Vendittelli, Françoise; Gervoise-Boyer, Marie-José

doi:10.1016/j.rbmo.2019.09.014

Cited by 7 publications

(2 citation statements)

References 65 publications

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“…This association has been partly found in previous studies. A study by Anzola et al concluded that the percentage of LGA was influenced by a high maternal BMI in IVF-FET cycles [ 28 ]. A retrospective analysis of 12,950 deliveries, which didn’t restrict the study population to offspring conceived via ART, investigated that women classified as obesity before pregnancy were at increased risk for LGA (16.8% vs 10.5%, OR 1.72, 95%CI 1.57–1.97) [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Association of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study

Chen

Liu

et al. 2021

BMC Pregnancy Childbirth

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Background Parental body mass index (BMI) is associated with pregnancy outcomes. But the effect of parental prepregnancy BMI on offspring conceived via in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI), especially the birth defect, remains to be determined. This study aimed to investigate the associations of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles. Methods We conducted a retrospective cohort study including 5741 couples in their first fresh IVF/ICSI cycles admitted to Women’s Hospital, School of Medicine, Zhejiang University from January 2013 to July 2016. The primary outcome was birth defects, which was classified according to the International Classification of Diseases, 10th Revision. Secondary outcomes included preterm delivery rate, infant gender, birth weight, small-for-gestational age (SGA) and large-for-gestational age (LGA). Multilevel regression analyses were used to assess the associations of parental prepregnancy BMI with neonatal outcomes and birth defect. Results In singletons, couples with prepregnancy BMI ≥25 kg/m2 had higher odds of LGA than those with BMI < 25 kg/m2. The birth defect rate was significantly higher when paternal prepregnancy BMI ≥25 kg/m2 in IVF cycles (aOR 1.82, 95% CI 1.06–3.10) and maternal BMI ≥25 kg/m2 in ICSI cycles (aOR 4.89, 95% CI 1.45–16.53). For subcategories of birth defects, only the odds of congenital malformations of musculoskeletal system was significantly increased in IVF offspring with paternal BMI ≥25 kg/m2 (aOR 4.55, 95% CI 1.32–15.71). For twins, there was no significant difference among four groups, except for the lower birth weight of IVF female infants. Conclusions Parental prepregnancy BMI ≥25 kg/m2 is associated with higher incidence of LGA in IVF/ICSI singletons. Paternal prepregnancy BMI ≥25 kg/m2 was likely to have higher risk of birth defect in IVF offspring than those with BMI < 25 kg/m2, particularly in the musculoskeletal system. It is essential for overweight or obesity couples to lose weight before IVF/ICSI treatments.

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Section: Discussionmentioning

confidence: 99%

Association of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study

Chen

Liu

et al. 2021

BMC Pregnancy Childbirth

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“…More data are required to enhance comprehension of the precise correlation between EMT and ART outcomes, thereby enabling the development of more effective fertility interventions (Kasius et al, 2014;Mahajan & Sharma, 2016). For the safety evaluation and standardization of the practice, the perinatal outcomes of ART still require careful evaluation (Beltran Anzola et al, 2019;Kushnir et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

The effects of endometrial thickness on outcomes of pregnancy following embryo transfer: A retrospective cohort

Safari,

Moazzezi,

Azizi

2024

JBRA

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Objective: The safety of assisted reproductive technology can be assessed by examining birth weight as an outcome measure. The objective of this study was to evaluate the effect of endometrial thickness during embryo transfer on newborn birth weight and preterm labor.Methods: We conducted a retrospective cohort study at the infertility department of a teaching hospital affiliated with a university of medical sciences. Eligible women were ≥18 years old and conceived a singleton pregnancy with embryo transfer and an endometrial thickness of ≥7 mm. None of the patients had diabetes, blood hypertension, and polycystic ovarian syndrome. We assessed maternal and newborn characteristics and perinatal pregnancy outcomes.Results: In total, 100 eligible patients with a mean (SD) age of 32.8 (6.2) years were included. The mean endometrial thickness during embryo transfer was 9.1 (1.2) mm, and the mean birth weight was 3040.7 (565.3)g. There were no statistically significant associations between endometrial thickness and preterm labor (p=0.215) and between endometrial thickness and stillbirth or intrauterine fetal death (p=0.880). However, after adjusting for confounding factors, the association of endometrial thickness with birth weight was statistically significant [b=124.6 (51.6), p=0.018].Conclusions: Within the range of ≥7mm, endometrial thickness during embryo transfer is a predictor of newborn weight; however, it is not related to the risk of preterm labor, stillbirth, or intra-uterine fetal death.

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Health and Well-Being Outcomes of Adolescents Conceived Through In Vitro Fertilization and Intracytoplasmic Sperm Injection

Gervoise-Boyer¹,

Anzola²,

Sambuc³

et al. 2020

Reprod. Sci.

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Birthweight of IVF children is still a current issue and still related to maternal factors

Cited by 7 publications

References 65 publications

Association of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study

Association of parental prepregnancy BMI with neonatal outcomes and birth defect in fresh embryo transfer cycles: a retrospective cohort study

The effects of endometrial thickness on outcomes of pregnancy following embryo transfer: A retrospective cohort

Health and Well-Being Outcomes of Adolescents Conceived Through In Vitro Fertilization and Intracytoplasmic Sperm Injection

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