Bis basic-substituted polycyclic aromatic compounds. New class of antiviral agents. 3. 2,7-Bis(aminoacyl)fluorenes and -fluorenones

Facile Diversity-Oriented Synthesis of Novel Dipeptide Mimetic Compounds Containing Bioactive Molecular Skeletons under Microwave Irradiation

“…Additionally, benzothiazole derivatives have received considerable attention over the past decades because of their wide range of bioactivity profiles including cytotoxic, antitumor, anticancer, , antimicrobial, immunosuppressive and antiviral properties . Moreover, fluorene derivatives have not only been used as antitumor, anticancer, and antiviral agents, but have also been proven to be apoptosis inducers and insulin secretagogues …”

“…Additionally, benzothiazole derivatives have received considerable attention over the past decades because of their wide range of bioactivity profiles including cytotoxic, 13 antitumor, 14 anticancer, 15,16a antimicrobial, 16 immunosuppressive and antiviral properties. 17 Moreover, fluorene derivatives have not only been used as antitumor, 18 anticancer, 19 and antiviral agents, 20 but have also been proven to be apoptosis inducers 21 and insulin secretagogues. 22 Considering the versatile bioactivities of the above-mentioned structures, we hypothesize that the integration of indazole, benzothiazole, or fluorene scaffold with a dipeptide segment may result in the discovery of new drug candidates with unknown bioactivities.…”