Bis(Tributyltin) Oxide Toxicology

Benya, Theodore J.

doi:10.3109/03602539709002247

Cited by 13 publications

(2 citation statements)

References 122 publications

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“…For example, male roach (Rutilus rutilus) housed in cages near to sewage outfalls in the UK synthesise the egg protein, vitellogenin, 3 and female dog whelk (Nucella lapillus) exposed to the antifouling agent tributyltin oxide in UK ports grow penises. 4 The potential for humans to be affected by exposure to xenoestrogens was first suggested by evidence of decreasing sperm count. 5 Although unproven, concern about human health effects continues.…”

Section: Introductionmentioning

confidence: 99%

Dietary exposure to xenoestrogens in New Zealand

Thomson

Cressey

Shaw

2003

J. Environ. Monitor.

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Continuing evidence of the feminising effects of xenoestrogens on a range of wildlife species increases the need to assess the human health risk of these estrogen mimics. We have estimated the exposure of New Zealand males, females and young men to a range of naturally occurring and synthetic xenoestrogens found in food. Only estrogenic compounds that act by interaction with the estrogen receptor have been included. Theoretical plasma estrogen activity levels were derived from estrogen exposure estimates and estrogenic potency data. Theoretical plasma levels were compared with published data for specific xenoestrogens. There was surprisingly close agreement. Xenoestrogenicity from dietary intake was almost equally attributed to naturally occurring and synthetic xenoestrogens. Relative contributions for a male, for example were isoflavones (genistein and daidzein) (36%) and bisphenol A (34%) with smaller contributions from alkyl phenols (18%) and the flavonoids (phloretin and kaempferol) (12%). It is suggested that dietary xenoestrogens might have a pharmacological effect on New Zealand males and postmenopausal women, but are unlikely to be significant for pre-menopausal women.

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Section: Introductionmentioning

confidence: 99%

Dietary exposure to xenoestrogens in New Zealand

Thomson

Cressey

Shaw

2003

J. Environ. Monitor.

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“…Human exposure to OTC may occur due to occupational exposure or, in the case of the general population, through ingestion of OTC residues in food, particularly in fish and seafood. Mammalian toxicity attributed to TBT and TPT is well established, affecting the immune and reproductive systems (Boyer, 1989;Fait et al, 1994;Benya, 1997;Ogata et al, 2001;Golub & Doherty, 2004). Since TBT and TPT were considered potential endocrine disruptors, there has been a renewed interest due to their adverse effects on mammalian reproduction (Golub & Doherty, 2004;Nakanishi, 2008).…”

mentioning

confidence: 99%

Postnatal Development and Fertility of Offspring from Mice Exposed to Triphenyltin (Fentin) Hydroxide During Pregnancy and Lactation

Sarpa

Lopes

Delgado

et al. 2010

Journal of Toxicology and Environmental Health, Part A

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Fentin or triphenylthin (TPT) is an organotin compound (OTC) widely used as an agricultural fungicide and miticide. It is well known that TPT exerts adverse effects on the reproductive and immune systems and may disrupt the endocrine system, raising concerns regarding the risks posed by exposure to this metal on environmental and human health. In this study the effects of maternal exposure to TPT at doses of control (0), 1.875, 3.75, or 7.5 mg/kg body weight/d, po, were examined during gestation and lactation on offspring growth, organ weights, and fertility. Except for a significant liver enlargement at the highest dose, TPT produced no maternal toxicity. Increased neonatal mortality (death of 3 entire litters from a total of 18 treated litters) was noted at 7.5 mg/kg. Pup body weight at birth was significantly reduced at all dose levels, but no marked weight loss was found on postnatal day (PND) 5 and thereafter. Offspring maturation (ear unfolding, incisor eruption, vagina opening, and testes descent) and fertility in adulthood were not significantly affected by maternal exposure to TPT. In conclusion, data provided by this study indicate that maternal treatment with TPT during pregnancy and lactation delayed prenatal growth but did not impair postnatal development and fertility in exposed offspring in adulthood.

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Tributylzinn‐Verbindungen

Nestler,

Terytze

2004

Bodengefährdende Stoffe: Bewertung ‐ Stoffdaten ‐ Ökotoxikologie ‐ Sanierung

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Tributylzinn‐Verbindungen zählen zu den Zinn‐organischen Verbindungen (Synonym: Organozinn‐Verbindungen) mit einer oder mehreren Sn‐C‐Bindungen und leiten sich mit wenigen Ausnahmen vom vierwertigen Zinn ab. Allgemein gehören sie zu den Metall‐organischen Verbindungen. Tributylzinn (TBT)‐Verbindungen stellen eine Untergruppe der Stoffgruppe der Trialkyl‐Organozinn‐Verbindungen (ebenfalls noch Trimethylzinn‐ und Trioktylzinn‐Verbindungen) dar. Trialkyl‐Organozinn‐Verbindungen sind ohne einen Substituenten einwertige Kationen. Tributylzinn‐Verbindungen werden aufgrund ihrer bioziden Wirkung in Antifouling‐Agenzien, im industriellen Holzschutz, als Zusatz für Polyvinylchlorid sowie im Materialschutz eingesetzt: Ihre Verwendung ist rückläufig. Sie zählen zu den giftigsten Stoffen für aquatische Organismen, die jemals in Gewässer eingetragen worden sind! Relative lange Abbauzeiten von TBT‐Verbindungen in Böden ermöglichen eine Akkumulation. Die Verwendung muss daher streng reglementiert und Emissionen überwacht werden.

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Bis(Tributyltin) Oxide Toxicology

Cited by 13 publications

References 122 publications

Dietary exposure to xenoestrogens in New Zealand

Dietary exposure to xenoestrogens in New Zealand

Postnatal Development and Fertility of Offspring from Mice Exposed to Triphenyltin (Fentin) Hydroxide During Pregnancy and Lactation

Tributylzinn‐Verbindungen

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