Bis(μ-alkoxo) bridged dinuclear CuII2 and ZnII2 complexes of an isoindol functionality based new ligand: Synthesis, structure, spectral characterization, magnetic properties and catechol oxidase activity

Patra, Anirban; Giri, Gopal C.; Sen, Tushar Kanti; Carrella, Luca M.; Mandal, Swadhin K.; Bera, Manindranath

doi:10.1016/j.poly.2013.09.034

Cited by 23 publications

(11 citation statements)

References 72 publications

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“…The metals were chosen from the list of 3d-metals used so far to design mimics of CO or PHS using different ligand systems viz. copper [24,, iron [25,[55][56][57], cobalt [58][59][60][61][62][63][64][65], manganese [66][67][68][69][70][71][72][73][74][75][76][77][78][79], nickel [26,68,[80][81][82][83] and zinc [33,84]. PHS mimics cannot be found as much as CO but yet are well studied with 3d-metals viz.…”

Section: Introductionmentioning

confidence: 99%

Investigation of 3d-transition metal acetates in the oxidation of substituted dioxolene and phenols

Dey

Mukherjee

2015

Journal of Molecular Catalysis A: Chemical

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Section: Introductionmentioning

confidence: 99%

Investigation of 3d-transition metal acetates in the oxidation of substituted dioxolene and phenols

Dey

Mukherjee

2015

Journal of Molecular Catalysis A: Chemical

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“…This latter complication is widely avoided in studies of catechol oxidase reactivity, because O 2 ‐saturated reaction media are used, and reactions quenched before dioxygen depletion of the solutions become kinetically virulent. We initially adopted these experimental settings from the literature to assess the activity of our model systems in oxygen‐saturated methanol ( method A ; stationary saturation), in which the concentration of dissolved dioxygen amounts to [O 2 ] 0 ≈11 m m around ambient temperature . Concentrations of substrate C and catalyst 2 (Cl) 2 were chosen in the way that oxygen depletion was negligible, even in the hypothetical case of complete substrate consumption.…”

Section: Resultsmentioning

confidence: 99%

Oxygen Delivery as a Limiting Factor in Modelling Dicopper(II) Oxidase Reactivity

Gülzow

Hörner

Strauch

et al. 2017

Chemistry A European J

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What is the most significant result of this study? Attempts to mimic metalloenzymes teach us about catalysis, and the lessons learnt find widespread application in an umber of chemical disciplines, including process engineering. Our catechol oxidase models show an unprecedented dependence of their reactivity on the method of oxygen administration:w hen going beyond the limits of homogeneously distributed reactants, by administering surplus dioxygen periodically during catalytic turnover, we observed reactivities increasing by factors of five to ten, in comparison with the well-established conditions of dioxygen saturation. This observation is not limited to our new system. Reference experiments with systems taken from the literature suggest that the effect, which is of interest in the context of reactive bubbly flows, is general, but has hitherto gone unnoticed. What was the inspiration for this cover design? When we were invited to submit ad esign, we took inspiration from the fact that the browning of cut fruit is effected by copper-and oxygen-dependent oxygenases, leading to melanine pigments, which are polymeric ortho-quinone derivatives. An abstract rendering of our dinuclear copper(II) complexes is shown in the foreground at left. In our cover art, as till life by Gabriele Endres, the browning of the half-eaten apple in the foreground denotes the enhanced reaction of our model substrate, ac atechol, under oxygen-enriched conditions, as provided by ab ubbly flow of oxygen. What other topics are you working on at the moment? We are interested in the activation of dioxygen and its exploitation as an environmentally benign, or green, oxidant, using bioinspired transition-metal complexes of tailor-made ligands. Our "workhorse" metal ions are iron and copper,i nt heir various oxidation states, and we are currently making our first forays into the coordination chemistry of manganese. Our ligands are polypodal, including tetra-and pentadentate ligands, as in the present work, or extended -tripodal hexadentate, as in recent spin-state dynamics studies. The former chelators shield am ajor part of the metal-coordination sphere, focusing the reactivity on one or two "labile" coordination sites. The coordinative strain of all these claw-like ligands can also be varied, enabling investigations, in which distortions of the coordination sphere and their influence on complex reactivity and spin multiplicity,c an be studied in isolation (and with reference to the concept of the entatic state). Invited for the cover of this issue is the group of Gerald Hçrner and Andreas Grohmann at the Technical University of Berlin. The image depicts that the browning of cut fruit is effected by copper-and oxygen-dependent oxygenases, leading to mela-nine pigments, which are polymeric ortho-quinone derivatives.R ead the full text of the article at

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“…[34][35][36][37][38] Among the different ligand systems employed in the design and synthesis of transition metal-based model complexes, the carboxylate containing multidentate ligands are an important class showing diverse applications, including broad biological activities. [39][40][41][42][43][44][45] In particular, carboxylate-based ligands are of special interest because of the variety of ways in which they are coordinated to metal ions. The most important coordination modes of the carboxylate groups are monodentate, syn-syn bidentate, syn-anti bidentate and anti-anti bidentate.…”

Section: Introductionmentioning

confidence: 99%

“…Among the different ligand systems employed in the design and synthesis of transition metal‐based model complexes, the carboxylate containing multidentate ligands are an important class showing diverse applications, including broad biological activities [39–45] . In particular, carboxylate‐based ligands are of special interest because of the variety of ways in which they are coordinated to metal ions.…”

Section: Introductionmentioning

confidence: 99%

Cu(II), Mn(II) and Zn(II) Complexes of Anthracene‐Affixed Carboxylate‐Rich Tridentate Ligand: Synthesis, Structure, Spectroscopic Investigation and Their DNA Binding Profile

et al. 2022

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Anthracene-affixed carboxylate-rich tridentate ligand containing three new mononuclear complexes, [Cu(acpa)(H 2 O) 2 ]⋅H 2 O (1), [Mn(acpa)(H 2 O) 2 ] (2) and [Zn(acpa)(H 2 O) 2 ] (3) (H 2 acpa = 3-(anthracene-9-ylmethyl-carboxymethyl-amino)-propionic acid), have been synthesized and characterized by various analytical and spectral methods. In methanol, complexes 1-3 have been prepared by carrying out reaction of the ligand H 2 acpa with stoichiometric amounts of CuSO 4 ⋅ 5H 2 O, MnSO 4 ⋅H 2 O and ZnSO 4 ⋅ 7H 2 O respectively, in the presence of NaOH at ambient temperature. The X-ray crystal structure analysis reveals that complex 1 consists of a distorted square pyramidal copper center, coordinated to one acpa 2À ligand in a tridentate manner (N,O,O) and two exogenous water molecules. On the other hand, the molecular structures of complexes 2 and 3, optimized by DFT method indicate that their core arrangements around the metal centers are similar to that of 1. In solution, the coordination phenomena of Cu((II), Mn(II) and Zn(II) ions with the ligand H 2 acpa and the structural features of the complexes have been authenticated by UV-Vis and fluorescence titration experiments. The composition of the M II /acpa 2À complexes (M = Cu, Mn, Zn) in 1-3 has been observed to be 1 : 1, based on the UV-Vis/fluorescence titration results which are further supported by X-ray crystallography and DFT calculation. Complexes 1-3 are investigated for their binding affinity towards Calf Thymus (CT) DNA in solution at pH ∼ 7.5 by UV-Vis and fluorescence spectroscopic methods. From the electronic absorption spectral studies, it has been found that the DNA binding constants of 1-3 are (5.67 � 0.32) × 10 4 M À 1 , (2.35 � 0.26) × 10 4 M À 1 and (2.49 � 0.33) × 10 4 M À 1 , respectively, following the order 1 > 3 > 2. Measurements of viscosity of DNA in the absence and presence of the metal complexes suggest that all three complexes interact with DNA through partial intercalative mode.

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Bis(μ-alkoxo) bridged dinuclear CuII2 and ZnII2 complexes of an isoindol functionality based new ligand: Synthesis, structure, spectral characterization, magnetic properties and catechol oxidase activity

Cited by 23 publications

References 72 publications

Investigation of 3d-transition metal acetates in the oxidation of substituted dioxolene and phenols

Investigation of 3d-transition metal acetates in the oxidation of substituted dioxolene and phenols

Oxygen Delivery as a Limiting Factor in Modelling Dicopper(II) Oxidase Reactivity

Cu(II), Mn(II) and Zn(II) Complexes of Anthracene‐Affixed Carboxylate‐Rich Tridentate Ligand: Synthesis, Structure, Spectroscopic Investigation and Their DNA Binding Profile

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