Bisabolane-Type Sesquiterpenes:  Liginvolones A−D from Ligusticum involucratum

Shibano, Makio; Okuno, Ayako; Taniguchi, Masahiko; K, Baba; Wang, Nian-He

doi:10.1021/np050008s

Cited by 9 publications

(1 citation statement)

References 8 publications

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“…Other bisabolane derivatives liginvolones A-D 84-87 have been isolated from Ligusticum involucratum. 81 Two new halogenated helianane derivatives 88 and 89 have been obtained from the sponge Spirastrella hartmani. 82 A synthesis of optically active vomifoliol stereoisomers and roseoside stereoisomers has been reported.…”

Section: Bisabolanementioning

confidence: 99%

Natural sesquiterpenoids

Fraga

2006

Nat. Prod. Rep.

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Section: Bisabolanementioning

confidence: 99%

Natural sesquiterpenoids

Fraga

2006

Nat. Prod. Rep.

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Palladium‐Catalysed Isomerisation of 2‐Vinylidenehydrofurans to 1,3‐Dienes and Some Aspects of Their Reactivity

Ghobsi¹,

Hacini²,

Wavrin³

et al. 2008

Eur J Org Chem

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The transformation of easily accessible 2‐vinylidenehydrofurans into stable 1,3‐dienes has been achieved by using catalytic amounts of palladium(0). These valuable compounds were then engaged in subsequent Diels–Alder reactions giving access to complex heterocyclic cores found in numerous natural products. A rationale for the regioselectivity of the Diels–Alder reactions with vinylfurans has been provided by DFT calculations. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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Suksdorfin Promotes Adipocyte Differentiation and Improves Abnormalities in Glucose Metabolism via PPARγ Activation

Iwase

Yamamoto

Nishimura

et al. 2017

Lipids

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Although the Apiaceae herb family has been traditionally used for the management of type 2 diabetes, its molecular mechanism has not been clarified. Coumarin derivatives, which are abundant in plants of the Apiaceae family, were evaluated for their effects on adipogenesis. We found that suksdorfin significantly promoted adipocyte differentiation and enhanced production of adiponectin, an anti-diabetic adipokine. We also demonstrated that suksdorfin activates peroxisome proliferator-activated receptor gamma (PPARγ), a master regulator of adipogenesis. Furthermore, we showed metabolic disorders in obese diabetic KK-A mice were attenuated by suksdorfin feeding. Suksdorfin intake induced adipocyte miniaturization and increased expression levels of PPARγ target genes related to adipocyte differentiation. These results indicated that suksdorfin induces adipogenesis in white adipose tissue (WAT) via the activation of PPARγ, leading to improvement of obesity-induced metabolic disorders. Therefore, suksdorfin-mediated amelioration of WAT dysfunctions might be responsible for the anti-diabetic effects of traditional herbal medicine therapy with Apiaceae.

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Bisabolane-Type Sesquiterpenes: Liginvolones A−D from Ligusticum involucratum

Abstract: Four new bisabolane-type sesquiterpenes, liginvolones A-D (1-4), a new coumarin, 4'-octanoyloxyosthenol (5), and 20 known constituents were isolated from Ligusticum involucratum. Their structures were elucidated on the basis of spectroscopic analyses and chemical methods.

Cited by 9 publications

References 8 publications

Natural sesquiterpenoids

Natural sesquiterpenoids

Palladium‐Catalysed Isomerisation of 2‐Vinylidenehydrofurans to 1,3‐Dienes and Some Aspects of Their Reactivity

Suksdorfin Promotes Adipocyte Differentiation and Improves Abnormalities in Glucose Metabolism via PPARγ Activation

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