Bisbenzylisoquinoline and hasubanane alkaloids from Stephania abyssinica (Dillon &amp; A. Rich) (Menispermeceae)

Omole, Ruth Anyango; Gathirwa, Jeremiah; Akala, Hosea; Malebo, Hamisi M.; Machocho, Alex K.; Hassanali, Ahmed; Ndiege, Isaiah O.

doi:10.1016/j.phytochem.2014.03.026

Cited by 10 publications

(7 citation statements)

References 8 publications

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“…52 Bisbenzylisoquinolines also exhibit significant antiparasitic activity. In 2014, Omole et al 48 during spring and autumn, application of the alkaloids at a concentration of 841.77 µM significantly reduced the nematode galling index, the number of females per gram of root, and the reproduction factor, as well as increased plant height, fresh and dry shoot weights, and root length. 74…”

Section: Antiparasitic and Insecticidal Activitiesmentioning

confidence: 98%

“…27 Laudanosine (43), pseudolaudanine (44), and rugosinone (45) were isolated from the whole herb of Thalictrum cirrhosum 43 ( Figure 3). Hendersine B methyl ester (46), bicucullinine (47), and hendersine B (48) were isolated from C. tomentella. 28…”

Section: 4′-oo-didemethylancistrocladinium a (A/b)mentioning

confidence: 99%

“…In 2014, two new compounds, (−)pseudocurine (55) and (−)-pseudoisocurine (56), were isolated from a leaf extract of Stephania abyssinica. 48 Tetrandrine (57) and fangchinoline (58) were isolated from Stephania tetrandra, which has been used for 2000 years as an antirheumatic herbal medicine in China. 49 In addition, (−)-O-O-dimethylgrisabine (59) from D. longipedicellata exhibited significant antiparasitic and antioxidant activities.…”

Section: Bisbenzylisoquinoline Alkaloidsmentioning

confidence: 99%

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Biologically active isoquinoline alkaloids covering 2014–2018

Shang

Yang

Morris‐Natschke

et al. 2020

Medicinal Research Reviews

147

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Isoquinoline alkaloids, an important class of N-based heterocyclic compounds, have attracted considerable attention from researchers worldwide since the early 19th century. Over the past 200 years, many compounds from this class were isolated, and most of them and their analogs possess various bioactivities. In this review, we survey the updated literature on bioactive alkaloids and highlight research achievements of this alkaloid class during the period of 2014-2018. We reviewed over 400 molecules with a broad range of bioactivities, including antitumor, antidiabetic and its complications, antibacterial, antifungal, antiviral, antiparasitic, insecticidal, anti-inflammatory, antioxidant, neuroprotective, and other activities. This review should provide new indications or directions for the discovery of new and better drugs from the original naturally occurring isoquinoline alkaloids.

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Section: Antiparasitic and Insecticidal Activitiesmentioning

confidence: 98%

Section: 4′-oo-didemethylancistrocladinium a (A/b)mentioning

confidence: 99%

Section: Bisbenzylisoquinoline Alkaloidsmentioning

confidence: 99%

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Biologically active isoquinoline alkaloids covering 2014–2018

Shang

Yang

Morris‐Natschke

et al. 2020

Medicinal Research Reviews

147

View full text Add to dashboard Cite

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“…Compound 40 exhibits strong antiplasmodial activity against both chloroquine-susceptible D6 and resistant W2 strains of P. falciparum (IC 50 0.29 ± 0.00 and 0.31 ± 0.01 μg/ml, respectively). Compound 41 shows moderate and mild activity (0.75 ± 0.11 and 1.65 ± 0.03 μg/ml, respectively) and compound 42 shows mild activity against W2 (IC 50 � 3.45 μg/ml) but was inactive against D6 (IC 50 � 10.25 μg/ml) [37]. Also, six alkaloids were isolated from Alseodaphne corneri.…”

Section: Phenanthroindolizine Alkaloidsmentioning

confidence: 99%

“…Evidence-Based Complementary and Alternative Medicine [36] ree new alkaloids, (-)-pseudocurine (40), (-)-pseudoisocurine (41), and (-)-10-oxoaknadinine (42) Bisbenzylisoquinoline alkaloids (40 and 41) and one hasubanane alkaloid (42) Leaf of Stephania abyssinica ey show strong-to-mild activity with IC 50 values ranging from 0.29 ± 0.00 to 1.65 ± 0.03 μg/mL against both chloroquinesusceptible D6 and chloroquine-resistant strains [37] Six known alkaloids including (+)-laurotetanine (43) and (+)-norstephasubine (44)…”

Section: Protoberberine Alkaloidsmentioning

confidence: 99%

Alkaloids from Plants with Antimalarial Activity: A Review of Recent Studies

Uzor

2020

Evidence-Based Complementary and Alternative Medicine

106

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Malaria is one of the major health problems in developing countries. The disease kills a large number of people every year and also affects financial status of many countries. Resistance of the plasmodium parasite, the causative agent, to the existing drugs, including chloroquine, mefloquine, and artemisinin based combination therapy (ACT), is a serious global issue in malaria treatment and control. This warrants an urgent quest for novel compounds, particularly from natural sources such as medicinal plants. Alkaloids have over the years been recognized as important phytoconstituents with interesting biological properties. In fact, the first successful antimalarial drug was quinine, an alkaloid, which was extracted from Cinchona tree. In the present review work, the alkaloids isolated and reported recently (2013 till 2019) to possess antimalarial activity are presented. Several classes of alkaloids, including terpenoidal, indole, bisindole, quinolone, and isoquinoline alkaloids, were identified with a promising antimalarial activity. It is hoped that the reports of the review work will spur further research into the structural modification and/or development of the interesting compounds as novel antimalarial drugs.

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Review of the Safety and Efficacy of Moringa oleifera

Stohs¹,

Hartman²

2015

Phytotherapy Research

416

247

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Moringa oleifera leaves, seeds, bark, roots, sap, and flowers are widely used in traditional medicine, and the leaves and immature seed pods are used as food products in human nutrition. Leaf extracts exhibit the greatest antioxidant activity, and various safety studies in animals involving aqueous leaf extracts indicate a high degree of safety. No adverse effects were reported in association with human studies. Five human studies using powdered whole leaf preparations of M. oleifera have been published, which have demonstrated anti-hyperglycemic (antidiabetic) and anti-dyslipidemic activities. These activities have been confirmed using extracts as well as leaf powders in animal studies. A rapidly growing number of published studies have shown that aqueous, hydroalcohol, or alcohol extracts of M. oleifera leaves possess a wide range of additional biological activities including antioxidant, tissue protective (liver, kidneys, heart, testes, and lungs), analgesic, antiulcer, antihypertensive, radioprotective, and immunomodulatory actions. A wide variety of polyphenols and phenolic acids as well as flavonoids, glucosinolates, and possibly alkaloids is believed to be responsible for the observed effects. Standardization of products is an issue. However, the results of published studies to date involving M. oleifera are very promising. Additional human studies using standardized extracts are highly desirable.

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Bisbenzylisoquinoline and hasubanane alkaloids from Stephania abyssinica (Dillon & A. Rich) (Menispermeceae)

Cited by 10 publications

References 8 publications

Biologically active isoquinoline alkaloids covering 2014–2018

Biologically active isoquinoline alkaloids covering 2014–2018

Alkaloids from Plants with Antimalarial Activity: A Review of Recent Studies

Review of the Safety and Efficacy of Moringa oleifera

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