Bismuth– and lead–texaphyrin complexes: towards potential α-core emitters for radiotherapy

Abstract

Lead(II)–texaphyrins and the first discrete binuclear μ–oxo bismuth(III)–texaphyrin are reported. The latter was characterized via single crystal X-ray diffraction analysis. Cell proliferation assays using the A2780 ovarian cancer cell line were used to determine the cytotoxicity of the complexes.

Hyaluronic acid-functionalized bismuth oxide nanoparticles for computed tomography imaging-guided radiotherapy of tumor

“…However, it has been suggested that the significant radiosensitization effect of Bi 2 S 3 NPs could be successfully realized through their inhibition effect on tumor growth in a tumor-bearing mice model, where intrinsic potential biological toxicity of sulfur element could not be ignored. 29 Furthermore, as we have known, the lower cost of bismuth element and higher radiation dose enhancement 30,31 compared to gold element could make the BiNP a better candidate for further commercial use. Thus, it is suggested that Bi 2 O 3 NP can be used as an ideal alternative to evaluate the therapeutic effect of nanomedicine-based radiosensitizers in the interstitial radiotherapy research.…”

Synthesis and Properties of AABAAB-Type Macroheterocyclic Compounds with Fragments of 1,2,4- and 1,3,4-Thiadiazole

“…The reaction mixture was washed by hot Макрогетероциклы / Macroheterocycles 2016 9(2) 206-210 water from phenol, and then was extracted by hexane in a Soxhlet apparatus. The product was purified by column chromatography on silica gel, eluting impurities by CH tetranitrilo-33H,34H-1,12,17,28-tetrathiodibenzo[c,q]- (1,6,17,22)-tetraazacyclodotriacontene (9) …”

“…Both modification of peripheral fragments of molecules and variation of the size of the coordination cavity of macrocyclic compounds allow for the development of therapeutic agents for photodynamic cancer therapy and viral disease, [1,2] as well as materials with unique optical, magnetic, semiconductor properties. [3,4] Macroheterocyclic compounds (Mc) with expanded coordination cavities comprised of 6 smaller heterocyclic moieties that are linked to each other via aza-bridges are fundamentally interesting.…”

Recent Developments in Texaphyrin Chemistry and Drug Discovery

“…39 Specifically, spectroscopic and mass spectrometric evidence was put forward to support the formation of the first lead(II) texaphyrin complexes 33 and 35 (cf. Figure 5).…”

“…Similar methods were used to confirm the formation of the first discrete binuclear μ -oxo bismuth(III) macrocyclic complex 34 , a system that was further characterized via a single crystal X-ray diffraction analysis. 39 …”