Bismuth Subnitrate in the Treatment of Arteriolar (Essential) Hypertension

Ayman, David

doi:10.1001/jama.1932.02730330027007

Cited by 8 publications

(7 citation statements)

References 8 publications

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“…Other than this, bismuth salts were found to be effective in the treatment of syphilis, hypertension, dyspepsia, diarrhea, H-pylori infection, etc. [45][46][47][48][49][50]. Among the various compounds of bismuth, colloidal bismuth subcitrate (CBS), bismuth subnitrate (BS) [51,52], bismuth subsalicylate (BSS), and ranitidine bismuth citrate (RBC) are explored in the literature for their effectiveness and mode of action as well as modifications [53][54][55][56].…”

Section: Properties and Applicationsmentioning

confidence: 99%

A Review on the Recent Advancements on Therapeutic Effects of Ions in the Physiological Environments

et al. 2022

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This review focuses on the therapeutic effects of ions when released in physiological environments. Recent studies have shown that metallic ions like Ag+, Sr2+, Mg2+, Mn2+, Cu2+, Ca2+, P+5, etc., have shown promising results in drug delivery systems and regenerative medicine. These metallic ions can be loaded in nanoparticles, mesoporous bioactive glass nanoparticles (MBGNs), hydroxyapatite (HA), calcium phosphates, polymeric coatings, and salt solutions. The metallic ions can exhibit different functions in the physiological environment such as antibacterial, antiviral, anticancer, bioactive, biocompatible, and angiogenic effects. Furthermore, the metals/metalloid ions can be loaded into scaffolds to improve osteoblast proliferation, differentiation, bone development, fibroblast growth, and improved wound healing efficacy. Moreover, different ions possess different therapeutic limits. Therefore, further mechanisms need to be developed for the highly controlled and sustained release of these ions. This review paper summarizes the recent progress in the use of metallic/metalloid ions in regenerative medicine and encourages further study of ions as a solution to cure diseases.

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Section: Properties and Applicationsmentioning

confidence: 99%

A Review on the Recent Advancements on Therapeutic Effects of Ions in the Physiological Environments

et al. 2022

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“…He also noted that the BP of these patients could be reduced by frequent visits, frequent visits plus pink-colored water, and sitting rest periods. 19 One contemporary theory of hypertension was that female sex hormones reduced BP. Ayman challenged the work of those who claimed that the ovarian follicular hormone sold as "Theelin" had a hypotensive effect.…”

Section: Symptoms and Bp Ayman Selected 40 Patients From The Hypertementioning

confidence: 99%

“…He found no evidence of a hypotensive effect. He also noted that the BP of these patients could be reduced by frequent visits, frequent visits plus pink‐colored water, and sitting rest periods 19 …”

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David Ayman, MD: An Early Investigator of Clinical Hypertension

Materson

Leclercq

2005

J of Clinical Hypertension

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Dr. David Ayman (1901-1986) was an astute clinician and observer who challenged medical dogma by performing placebo-controlled studies and by meticulous measurement of blood pressure under standardized conditions. He demonstrated that almost all drugs reported to have an antihypertensive effect in the early 20th century had achieved nothing more than placebo response. He noted the marked variability of blood pressure and devised methods to reduce that variability. These observations led to his publications concerning what is now known as "white coat" or office hypertension. He determined blood pressure personally in 1524 members of 277 families over three generations and made observations on the hereditary nature of hypertension that countered the single-gene thinking of the day. His work is proof that clinical inquisitiveness, hard work, and the courage to challenge conventional wisdom can result in significant contributions to medicine and science.

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“…GUTMAN (1941) listed more than 100 preparations including, among others, barbiturates, nitrites, liver extracts, misteltoe extracts, and a great number of ill-defined "patent medicines". Bismuth subnitrate was used as an antihypertensive in the years 1927 to 1935 (STIEGLITZ, 1928(STIEGLITZ, , 1932 AYMAN, 1932). Intravenous injections of an aqueous solution of n-octyl alcohol were claimed to have an antihypertensive effect (AYMAN, 1930;CLERK et aI., 1933;RACINE, 1935; PEZZANGARO, 1936).…”

Section: Early Antihypertensivesmentioning

confidence: 99%

The Chemistry of Antihypertensive Agents

Schlittler¹

1977

Antihypertensive Agents

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Bismuth Subnitrate in the Treatment of Arteriolar (Essential) Hypertension

Cited by 8 publications

References 8 publications

A Review on the Recent Advancements on Therapeutic Effects of Ions in the Physiological Environments

A Review on the Recent Advancements on Therapeutic Effects of Ions in the Physiological Environments

David Ayman, MD: An Early Investigator of Clinical Hypertension

The Chemistry of Antihypertensive Agents

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