Bisoprolol Improves Echocardiographic Parameters of Left Ventricular Diastolic Function in Patients with Systemic Hypertension

Abstract

Left ventricular (LV) diastolic dysfunction (LVD) is a common complication secondary to hypertension. It has been reported that bisoprolol is effective in reducing blood pressure and has beneficial cardiac effects in patients with hypertension. However, its effect on LV diastolic function has not been studied in detail. In this study, we sought to determine bisoprolol’s effect on left ventricle diastolic function. Data from 25 patients were statistically analyzed. Peaks E and A wave, E/A ratio, isovolumetric relaxation time and E wave deceleration time were measured echocardiographically. Doppler echocardiography measurements after bisoprolol treatment revealed an improvement in LV diastolic function. In conclusion, our results show that treatment with bisoprolol, improves echocardiographic parameters of LV diastolic function after 3 months of treatment.

Development and evaluation of fixed dose bi therapy sublingual tablets for treatment stress hypertension and anxiety

“…That led to decrease in SBP[45] and improve diastolic function in the left ventricle, which led to decrease in DBP. [46] Bu as reported by Shingala and Balaraman, 2005,[4] has an antihypertensive effect through aortic effect and vascular activity (DBP) Furthermore, it was reported that Bu reduced the SBP. [47]…”

Differential Effects of Antihypertensive Treatment on Left Ventricular Diastolic Function

“…In general, studies have used small samples sizes (8,21,24 -26) and have been underpowered to detect a difference between therapies. The majority of study durations have ranged from just a few weeks to 6 months (21,25,26), and very few studies have extended to a year of follow-up (8,24,27). Moreover, conventional echocardiography alone, which has been used in the majority of published studies, has limitations as a means of assessing LV diastolic function (28,29).…”

Long-Term Treatment with Valsartan Improved Cyclic Variation of the Myocardial Integral Backscatter Signal and Diastolic Dysfunction in Hypertensive Patients: The Echocardiographic Assessment

“…None of the enrolled patients was taking aldosterone antagonists, which may reduce myocardial fibrosis (24). Because β-blockers may affect E/A ratio in hypertensive patients (25), a subgroup analysis was performed by excluding five patients treated with a β-blocker, but the results were not different without those patients (data not shown). Accordingly, it is suggested that improvement of diastolic function may be caused by valsartan-induced attenuation of myocardial fibrosis in the low IBS-CV group.…”