Bisorbicillinol inhibits Lyn tyrosine kinase for allergic response on RBL-2H3 cells

Sugaya, Kouichi; Terajima, Takehito; Takahashi, Aika; Onose, Jun‐ichi; Abe, Naoki

doi:10.1016/j.bmcl.2019.01.019

Cited by 7 publications

(2 citation statements)

References 26 publications

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“…The results showed that the inhibitory mechanism of β-hexosaminidase release and TNF-α secretion involve inhibition of Lyn, a tyrosine kinase. This indicated that bisorbicillinol (82) should be a candidate antiallergic agent [46].…”

Section: Other Biological Activitiesmentioning

confidence: 99%

Recent Advances in Sorbicillinoids from Fungi and Their Bioactivities (Covering 2016–2021)

Hou

Zhang

Xue

et al. 2022

JoF

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Sorbicillinoids are a family of hexaketide metabolites with a characteristic sorbyl side chain residue. Sixty-nine sorbicillinoids from fungi, newly identified from 2016 to 2021, are summarized in this review, including their structures and bioactivities. They are classified into monomeric, dimeric, trimeric, and hybrid sorbicillinoids according to their basic structural features, with the main groups comprising both monomeric and dimeric sorbicillinoids. Some of the identified sorbicillinoids have special structures such as ustilobisorbicillinol A, and sorbicillasins A and B. The majority of sorbicillinoids have been reported from fungi genera such as Acremonium, Penicillium, Trichoderma, and Ustilaginoidea, with some sorbicillinoids exhibiting cytotoxic, antimicrobial, anti-inflammatory, phytotoxic, and α-glucosidase inhibitory activities. In recent years, marine-derived, extremophilic, plant endophytic, and phytopathogenic fungi have emerged as important resources for diverse sorbicillinoids with unique skeletons. The recently revealed biological activities of sorbicillinoids discovered before 2016 are also described in this review.

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Section: Other Biological Activitiesmentioning

confidence: 99%

Recent Advances in Sorbicillinoids from Fungi and Their Bioactivities (Covering 2016–2021)

Hou

Zhang

Xue

et al. 2022

JoF

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“…Bisorbicillinoids are complex polyketides derived from fungi such as Trichoderma 6,7 and Penicillium. 8 These natural products are known for their diverse biological activities, including antioxidant 9 and antiallergic 10 properties. Previous reports have proposed that the biosynthesis of bisorbicillinoids involves the Diels-Alder-type dimerization of two sorbicillinol derivatives (Fig.…”

Section: Introductionmentioning

confidence: 99%

Theoretical study of the rearrangement reaction in bisorbicillinoid biosynthesis: insights into the molecular mechanisms involved

Nakano

Sato

2023

Org. Biomol. Chem.

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Variegatic acid from the edible mushroom Tylopilus ballouii inhibits TNF-α production and PKCβ1 activity in leukemia cells

Sugaya

Ino

Matsuo

et al. 2020

Bioorganic & Medicinal Chemistry Letters

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Bisorbicillinol inhibits Lyn tyrosine kinase for allergic response on RBL-2H3 cells

Cited by 7 publications

References 26 publications

Recent Advances in Sorbicillinoids from Fungi and Their Bioactivities (Covering 2016–2021)

Recent Advances in Sorbicillinoids from Fungi and Their Bioactivities (Covering 2016–2021)

Theoretical study of the rearrangement reaction in bisorbicillinoid biosynthesis: insights into the molecular mechanisms involved

Variegatic acid from the edible mushroom Tylopilus ballouii inhibits TNF-α production and PKCβ1 activity in leukemia cells

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