Bisphenol A and other compounds in human saliva and urine associated with the placement of composite restorations

Kingman, Albert; Hyman, Jeffrey; Masten, Scott A.; Jayaram, B.; Smith, Cynthia R.; Eichmiller, Frederick C.; Arnold, Michael C.; Wong, Paul A.; Schaeffer, James M.; Solanki, Sheetal; Dunn, William J.

doi:10.14219/jada.archive.2012.0090

Cited by 99 publications

(93 citation statements)

References 17 publications

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“…As the release was measured to be spread over 3 days, the short-term exposure would be between 0.43 and 4.43 μg/kg bw/day. These in vitro data could not be confirmed by other groups, but small amounts of BPA released from dental resins were found immediately and within a day or two after placement (e.g., [2,8]). The question remains, which impact these data have for the patient, the dental personnel and the environment.…”

contrasting

confidence: 60%

BPA from dental resin material: where are we going with restorative and preventive dental biomaterials?

2014

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contrasting

confidence: 60%

BPA from dental resin material: where are we going with restorative and preventive dental biomaterials?

2014

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“…In clinical dentistry, BPA is a precursor of the bisphenol A glycidyl methacrylate (Bis-GMA), bisphenol A dimethacrylate (Bis-DMA), and bisphenol A ethoxylated dimethacrylate (Bis-EMA) monomers found in dental sealants, adhesive resins, 2 and composite resins. The degradation of these materials can leach BPA [3][4][5][6] into the oral environment, which could be a clinical concern and could be exacerbated by temperature changes, mechanical wear, 7 changes in pH, 8 and bacterial or salivary enzymatic action.…”

Section: Introductionmentioning

confidence: 99%

An investigation into bisphenol-A leaching from orthodontic materials

Kotyk¹,

Wiltshire

2013

The Angle Orthodontist

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Objective: To quantitatively determine the bisphenol-A (BPA) leached from orthodontic materials during simulated intraoral exposure. Materials and Methods: Samples of orthodontic materials were subjected to simulated abrasion, immersion in artificial saliva, thermal shock via temperature cycling, and simulated intraoral exposure. Sample aliquots were collected for up to 2 weeks after artificial saliva immersion, derivatized, then analyzed for BPA by gas chromatography/mass spectroscopy. Results: Quantifiable amounts of leached BPA were observed from a thermoformed orthodontic retainer material (7.63 mg/g of material) and an orthodontic adhesive (2.75 mg/g of material). BPA leaching was only observed within the first 3 days of artificial saliva immersion. Conclusions: Under the test conditions, BPA was observed to leach from two orthodontic materials. While the quantities of leached BPA were below the reference dose for daily intake, existing data of low-dose effects and medical disorders associated with elevated urinary BPA levels suggest that BPA exposure, and thus the use of the leaching materials identified in this study, should be reduced or eliminated. (Angle Orthod. 2014;84:516-520.)

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“…So, residual BPA, not chemically converted into bis-GMA, is likely present in trace amounts in any dental material containing these ingredients of dental composites and sealants degrading in the oral cavity by the action of salivary enzymes [30]. Thus, dental treatment with composite restorations could be a possible source of exposure to BPA for each individual being currently or potentially dental patient [31] as well as for occupationally exposed dental professionals and for dental students during their educational course.…”

Section: Discussionmentioning

confidence: 99%

Pilot study of contact sensitization to rubber allergens and bisphenol A amongst dental students

Lyapina

Krasteva

Dencheva

et al. 2017

Int J Occup Med Environ Health

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Objectives: The aim of this study has been to evaluate the rate of contact sensitization to some rubber allergens and to bisphenol A (BPA) amongst students of dental medicine and dental patients. Material and Methods: A total of 50 participants were included in the study: 40 students of dental medicine exposed to the studied rubber allergens and BPA-based dental materials during the course of their education; 10 dental patients without occupational exposure to the latter substances served as a control group. All of them were patch-tested with the studied rubber allergens and bisphenol A. Results: Highest was the sensitizing action of carba mix, followed by benzoyl peroxide and mercapto mix. The sensitization rate for carba mix was significantly higher for dental students as well as for the whole studied population, if compared to the one for thiuram mix (Chi 2 = 12.9, p < 0.001; Chi 2 = 13.9, p < 0.001), bisphenol A (Chi 2 = 8.9, p < 0.001; Chi 2 = 11.9, p < 0.001), toluenesulfonamide formaldehyde resin (Chi 2 = 10.7, p < 0.001; Chi 2 = 13.9, p < 0.001) and benzoyl peroxide (Chi 2 = 4.7, p = 0.03; Chi 2 = 5.8, p = 0.016), and for dental patients, if compared to the one for mercapto mix (Chi 2 = 7.07, p = 0.008). Concomitant positive skin patch-test reactions to carba mix and to benzoyl peroxide, and to all the studied allergens were established. Conclusions: Carba mix could be outlined as a sensitizer of paramount importance for dental students as well as for dental patients. Benzoyl peroxide was the second ranked sensitizer for dental students. Positive skin patch-test reactions to bisphenol A and toluenesulfonamide formaldehyde resin were established only among the group of dental students. Int J Occup Med Environ Health 2017;30(3):397-405

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Bisphenol A and other compounds in human saliva and urine associated with the placement of composite restorations

Cited by 99 publications

References 17 publications

BPA from dental resin material: where are we going with restorative and preventive dental biomaterials?

BPA from dental resin material: where are we going with restorative and preventive dental biomaterials?

An investigation into bisphenol-A leaching from orthodontic materials

Pilot study of contact sensitization to rubber allergens and bisphenol A amongst dental students

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