BPA from dental resin material: where are we going with restorative and preventive dental biomaterials?

The wide use of chairside CAD/CAM restorations has increased the diversity of the restorative material. For the practitioner, the selection of the appropriate material is difficult amongst the variety offered by the market. Information on the characteristics of the products can be difficult to assess due to the lack of up-to-date classification and the lack of reliability of manufacturer's advertising. The purpose of this article is to structure the data on restorative materials provided by various sources in order for the practitioner to choose the product most suited to the clinical situation. The objective is to classify chairside CAD/CAM materials and to define their characteristics and indications.

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“…However, the biocompatibility of materials containing resins is questionable, because possible release of monomers, as bisphenol-A. 42 43 …”

Section: Introductionmentioning

confidence: 99%

Dental biomaterials for chairside CAD/CAM: State of the art

Lambert

Durand

Jacquot³

et al. 2017

J Adv Prosthodont

138

107

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“…Resin-based dental materials contain BPA derivatives that can release this chemical in its raw form due to the incomplete monomer polymerization or as a result of material degradation [ 30 , 31 ]. Previous studies [ 21 , 32 , 33 ] have reported that the levels of BPA released by this type of dental material are below the recommended limit, but these low doses are considered as an additional source of exposure and could cause adverse effects [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

Association between polymorphisms in genes encoding estrogen receptors (ESR1 and ESR2) and excreted bisphenol A levels after orthodontic bracket bonding: a preliminary study

et al. 2018

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BackgroundBisphenol A (BPA) is released from orthodontic composites used for bracket bonding. Genetic variations could modify the metabolism of this chemical within the organism. Considering that free BPA binds to estrogen receptors causing harmful effects to health, the present in vivo study aimed to evaluate the association between genetic polymorphisms in genes encoding estrogen receptors (ESR1 and ESR2) and excreted BPA levels in orthodontic patients.MethodsQuantification of BPA levels in the urine of 16 patients was performed in a gas chromatograph mass spectrometer before (T0), at 24 h (T1), and 1 week (T2) after bracket bonding. DNA was extracted from saliva, and one genetic polymorphism in ESR1 (rs2234693) and two in ESR2 (rs4986938 and rs1256049) were analyzed by real-time PCR. Increases in BPA levels in the urine at T1 and T2 were grouped according to the genotype, and mean differences were compared by unpaired T test or Mann-Whitney test according to the normality of the data. The established alpha was 5%.ResultsBPA levels increased significantly at T1 and T2. There were no statistically significant differences in the increases in BPA levels according to the genotype for any genetic polymorphism (P > 0.05), at neither 24 h nor 1 week after bracket bonding.ConclusionsThe results suggested that there are no association between excreted BPA levels after bracket bonding and the evaluated genetic polymorphisms in ESR1 and ESR2. Further research should be performed in order to confirm these results.

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“…In addition to new scientific findings and their clinical implications, this topic has attracted strong public interest (eg, the discussion of mercury in amalgam and, more recently, the controversy over bisphenol A in resin-based composites). 1 Consequently, legal regulations concerning the safety of materials used in general medicine, including those used in dentistry, have been put into force. 2 Interestingly, dental research has been on the forefront of the medical field with respect to the development of tests, standards, and legal regulations related to material tissue interactions.…”

Section: Introductionmentioning

confidence: 99%

Material Tissue Interaction—From Toxicity to Tissue Regeneration

Schmalz

Widbiller

Galler

2016

Operative Dentistry

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The topic of material tissue interaction has gained increasing interest over recent decades from both the dental profession and the public. The primary goal initially was to avoid adverse reactions after the application of dental materials. New laboratory test methods have been developed, and currently premarket testing programs, which attempt to guarantee a basic level of patient safety, are legally required worldwide. The dentist is responsible for selecting the correct indication as well as the proper handling of any newly emerging risk. Apart from this phenomenon-oriented "inert materials concept," the "analytical concept" focuses primarily on analyzing the reasons for adverse reactions, and identifying their associated modifying factors, in order to prevent them or to develop new and more biocompatible materials. The "concept of bioactivity" involves addressing the possibility of positively influencing tissue by materials application, such as the generation of tertiary dentin or antibacterial effects. Finally, tissue regeneration may be supported and promoted by the use of various suitable materials (matrices/scaffolds) into which stem cells can migrate or be seeded, leading to cell differentiation and the generation of new tissue. These new dental materials must also fulfill additional requirements such as controlled degradability in order to be suitable for clinical use. Clearly, the field of material tissue interaction is complex and comprises a wide range of issues. To be successful as dentists in the future, practitioners should remain informed of these important new developments and have the argumentative competence to both properly advise and treat their patients.

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BPA from dental resin material: where are we going with restorative and preventive dental biomaterials?

Cited by 13 publications

References 18 publications

Dental biomaterials for chairside CAD/CAM: State of the art

Dental biomaterials for chairside CAD/CAM: State of the art

Association between polymorphisms in genes encoding estrogen receptors (ESR1 and ESR2) and excreted bisphenol A levels after orthodontic bracket bonding: a preliminary study

Material Tissue Interaction—From Toxicity to Tissue Regeneration

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