Bisphenol A and the Risk of Obesity a Systematic Review With Meta-Analysis of the Epidemiological Evidence

Wu, Wentao; Li, Minmin; Liu, Amin; Wu, Chenlu; Li, Daning; Deng, Qiwei; Zhang, Binyan; Du, Jinpeng; Gao, Xiangyu; Yan, Hong

doi:10.1177/1559325820916949

Cited by 78 publications

(31 citation statements)

References 44 publications

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“…A recent meta-analysis of data collected in adults and children reported a dose–response analysis of different studies. This analysis found that a 1 ng/mL increase in BPA levels increased the risk of obesity by around 11% [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with Exposure to Dietary Bisphenols in Adolescents

et al. 2021

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Obesogenic endocrine-disrupting chemicals, such as bisphenol A (BPA) and its analogue bisphenol S (BPS), seem to play an important role in the development of obesity, although contradictory results have been reported. The aim of the present study was to conduct a gender analysis of the factors associated with exposure to dietary bisphenols in 585 Spanish adolescents. Dietary BPA and BPS exposure was assessed using a food frequency questionnaire. Foods and macronutrients accounting for more than 95% of energy intake were selected for analysis. Stepwise regression was used to estimate the foods that most contributed to dietary bisphenol exposure in the sample. Gender-related factors associated with greater dietary bisphenol exposure were evaluated using multivariate logistic regression models. Canned tuna was the main dietary source of BPA and BPS in both adolescent boys and girls. Overweight/obese girls showed a higher risk of high dietary exposure to BPA (odds ratio (OR): 3.38, 95% confidence interval (CI): 1.25–9.07) and total bisphenols (OR: 2.81, 95% CI: 1.03–7.67) in comparison with girls with a BMI lower than 25 kg/m2. Present results indicate a positive association of dietary exposure to both total bisphenols and BPA with being overweight/obese in adolescent girls.

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Section: Discussionmentioning

confidence: 99%

Factors Associated with Exposure to Dietary Bisphenols in Adolescents

et al. 2021

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“…The literature review shows that BPA is not only an endocrine-disrupting chemical, but it also causes damage to hepatocytes through oxidative stress (Kourouma et al 2015 ; Elswefy et al 2016 ; Li et al 2017 ). BPA can modulate the immune response, has mutagenic activity toward eukaryotic cells, and leads to obesity (Michałowicz 2014 ; Wu et al 2020b ). Moreover, BPA disrupts microtubule organization and centrosome function, hence showing the vast spectrum of cancer-promoting effects, including induction of prostate and mammary cancer formation (Seachrist et al 2016 ; Ho et al 2017 ; Mesnage et al 2017 ).…”

Section: Endocrine-disrupting Chemicalsmentioning

confidence: 99%

White rot fungi can be a promising tool for removal of bisphenol A, bisphenol S, and nonylphenol from wastewater

Grelska

Noszczyńska

2020

Environ Sci Pollut Res

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Endocrine-disrupting chemicals (EDC) are a wide group of chemicals that interfere with the endocrine system. Their similarity to natural steroid hormones makes them able to attach to hormone receptors, thereby causing unfavorable health effects. Among EDC, bisphenol A (BPA), bisphenol S (BPS), and nonylphenol (NP) seem to be particularly harmful. As the industry is experiencing rapid expansion, BPA, BPS, and NP are being produced in growing amounts, generating considerable environmental pollution. White rot fungi (WRF) are an economical, ecologically friendly, and socially acceptable way to remove EDC contamination from ecosystems. WRF secrete extracellular ligninolytic enzymes such as laccase, manganese peroxidase, lignin peroxidase, and versatile peroxidase, involved in lignin deterioration. Owing to the broad substrate specificity of these enzymes, they are able to remove numerous xenobiotics, including EDC. Therefore, WRF seem to be a promising tool in the abovementioned EDC elimination during wastewater treatment processes. Here, we review WRF application for this EDC removal from wastewater and indicate several strengths and limitations of such methods.

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“…Indeed, BPA accumulates in adipose tissue and increases the number and size of adipocytes, thus contributing to increased adiposity and weight gain [ 16 ]. Moreover, a recent systematic review with a meta-analysis of the relevant epidemiological evidence reported that BPA exposure shows a significant positive association with indices of both generalized and central/abdominal obesity [ 17 , 18 ]. Similarly, systematic review data also support a relationship between BPA exposure and type 2 diabetes (T2DM) [ 19 ].…”

Section: Bpa and Comorbidities Predisposing To Severe Covid-19mentioning

confidence: 99%

Is There a Link between Bisphenol A (BPA), a Key Endocrine Disruptor, and the Risk for SARS-CoV-2 Infection and Severe COVID-19?

Zahra

Sisu

Silva

et al. 2020

JCM

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Infection by the severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV-2) is the causative agent of a new disease (COVID-19). The risk of severe COVID-19 is increased by certain underlying comorbidities, including asthma, cancer, cardiovascular disease, hypertension, diabetes, and obesity. Notably, exposure to hormonally active chemicals called endocrine-disrupting chemicals (EDCs) can promote such cardio-metabolic diseases, endocrine-related cancers, and immune system dysregulation and thus, may also be linked to higher risk of severe COVID-19. Bisphenol A (BPA) is among the most common EDCs and exerts its effects via receptors which are widely distributed in human tissues, including nuclear oestrogen receptors (ERα and ERβ), membrane-bound oestrogen receptor (G protein-coupled receptor 30; GPR30), and human nuclear receptor oestrogen-related receptor gamma. As such, this paper focuses on the potential role of BPA in promoting comorbidities associated with severe COVID-19, as well as on potential BPA-induced effects on key SARS-CoV-2 infection mediators, such as angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2). Interestingly, GPR30 appears to exhibit greater co-localisation with TMPRSS2 in key tissues like lung and prostate, suggesting that BPA exposure may impact on the local expression of these SARS-CoV-2 infection mediators. Overall, the potential role of BPA on the risk and severity of COVID-19 merits further investigation.

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Bisphenol A and the Risk of Obesity a Systematic Review With Meta-Analysis of the Epidemiological Evidence

Cited by 78 publications

References 44 publications

Factors Associated with Exposure to Dietary Bisphenols in Adolescents

Factors Associated with Exposure to Dietary Bisphenols in Adolescents

White rot fungi can be a promising tool for removal of bisphenol A, bisphenol S, and nonylphenol from wastewater

Is There a Link between Bisphenol A (BPA), a Key Endocrine Disruptor, and the Risk for SARS-CoV-2 Infection and Severe COVID-19?

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