Bisphenol a (BPA) induces abnormal androgen accumulation via androgen-androgen receptor (AR) mdiated cyp19a1 transcription inhibition in granulosa cells (GCs)

Pan, Jiexue; Wang, F.-F.; Liu, Y.; Meng, Qin; Sheng, Jian‐Zhong; Huang, He‐Feng

doi:10.1016/j.fertnstert.2013.07.164

Cited by 4 publications

(3 citation statements)

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“…The heritability of this disorder goes beyond simple Mendelian genetics. Epigenetic and environmental factors have been proposed as confounding factors that modulate the phenotype of genetic basis of PCOS [ 7 , 34 ]. DNA methylation patterns are neither fixed nor consistent among different tissues and have highly spatio-temporal dynamics that require continuous regulation [ 35 – 37 ].…”

Section: Discussionmentioning

confidence: 99%

Aberrant expression and DNA methylation of lipid metabolism genes in PCOS: a new insight into its pathogenesis

et al. 2018

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BackgroundPolycystic ovary syndrome (PCOS), whose etiology remains uncertain, is a highly heterogenous and genetically complex endocrine disorder. The aim of this study was to identify differentially expressed genes (DEGs) in granulosa cells (GCs) from PCOS patients and make epigenetic insights into the pathogenesis of PCOS.ResultsIncluded in this study were 110 women with PCOS and 119 women with normal ovulatory cycles undergoing in vitro fertilization acting as the control group. RNA-seq identified 92 DEGs unique to PCOS GCs in comparison with the control group. Bioinformatic analysis indicated that synthesis of lipids and steroids was activated in PCOS GCs. 5-Methylcytosine analysis demonstrated that there was an approximate 25% reduction in global DNA methylation of GCs in PCOS women (4.44 ± 0.65%) compared with the controls (6.07 ± 0.72%; P < 0.05). Using MassArray EpiTYPER quantitative DNA methylation analysis, we also found hypomethylation of several gene promoters related to lipid and steroid synthesis, which might result in the aberrant expression of these genes.ConclusionsOur results suggest that hypomethylated genes related to the synthesis of lipid and steroid may dysregulate expression of these genes and promote synthesis of steroid hormones including androgen, which could partially explain mechanisms of hyperandrogenism in PCOS.Electronic supplementary materialThe online version of this article (10.1186/s13148-018-0442-y) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Aberrant expression and DNA methylation of lipid metabolism genes in PCOS: a new insight into its pathogenesis

et al. 2018

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“…Epigenetic and environmental factors have been proposed as confounding factors that modulate the phenotype of genetic basis of ovarian hyperandrogenism. 58,79 Alternative splicing has been reported as an intrinsic epigenetic cause of ovarian hyperandrogenism. 80 An unfavorable in utero environment may potentially lead to premature adrenarche, and higher levels of dehydroepiandrosterone sulphate (DHEA-…”

Section: Epigenetic and Environmental Factorsmentioning

confidence: 99%

“…65 Environmental endocrinedisrupting chemicals may also lead to ovarian hyperandrogenism through interfering with ovarian functions and the associated metabolism. 79 Among those chemicals, bisphenol A (BPA) is a widely-used estrogenic industrial plasticizer, which can be detected in most individuals. 81 BPA has been found to improve androgen production in rat theca cells, 82 and serum androgen levels are positively associated with BPA levels.…”

Section: Excessive Steroidogenic Activitymentioning

confidence: 99%

Androgens as double-edged swords: Induction and suppression of follicular development

Pan¹,

Zhang²,

Ke³

et al. 2015

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Androgens, which are mediated via the androgen receptor (AR), play important roles in normal follicular development and female fertility. However, just like a double-edged sword, besides the positive effects of androgen on follicular development, abnormal androgen levels, especially as in hyperandrogenism, seriously suppress normal follicular development. A crucial balance exists between the importance of androgens in follicular development and their negative effects when in excess. As the first meiotic division and epigenetic reprogramming are two critical events in oogenesis, abnormal androgen levels or deficiency in androgen/AR signaling in the ovary may affect these vital events. Oocytes have a tendency to develop genomic instability, thus resulting in an increasing incidence of unpredictable adult diseases. Although many studies have explored the effects of androgens and AR on follicular development, the conclusions are controversial and there has been no thorough review of this topic. This review focuses on the roles of androgens in the physiological process of follicular development, summarizes new insights into the roles of androgens in the arrested development of follicles, and discusses the potential risk of adult diseases originating from abnormal follicular androgen levels or androgen receptor signals, which may determine areas for future studies.

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Hazards of bisphenol A —— blocks RNA splicing leading to abnormal testicular development in offspring male mice

et al. 2019

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Bisphenol a (BPA) induces abnormal androgen accumulation via androgen-androgen receptor (AR) mdiated cyp19a1 transcription inhibition in granulosa cells (GCs)

Cited by 4 publications

References 0 publications

Aberrant expression and DNA methylation of lipid metabolism genes in PCOS: a new insight into its pathogenesis

Aberrant expression and DNA methylation of lipid metabolism genes in PCOS: a new insight into its pathogenesis

Androgens as double-edged swords: Induction and suppression of follicular development

Hazards of bisphenol A —— blocks RNA splicing leading to abnormal testicular development in offspring male mice

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