Bisphenol A in human saliva and urine before and after treatment with dental polymer‐based restorative materials

Abstract

The aim of this study was to quantify bisphenol A (BPA) concentrations in saliva and urine before and after treatment with dental polymer‐based restorative materials to assess if placement of this material is associated with increased BPA levels in saliva and urine. Twenty individuals in need of at least one dental restoration with polymer‐based restorative material were included in this study. The participants were instructed to abstain from eating, drinking, and brushing their teeth for at least 10 h prior to sampling. Saliva and urine were collected before and 10 min (saliva only), 1 h, 24 h, and 1 wk after treatment. Samples were stored at −80°C before analyses. BPA in saliva and urine was determined with liquid chromatography/mass spectrometry. Linear mixed effects regression models were used for statistical analyses. There was a statistically significant increase of salivary BPA concentration directly after placement of the dental polymer‐based restorations. Following placement, the concentration of BPA decreased exponentially with time. One week after treatment the BPA level in saliva was only marginally higher than before treatment. In urine, no statistically significant change of the BPA concentration was detected after treatment.

Contrasting prenatal nutrition and environmental exposures in association with birth weight and cognitive function in children at 7 years

“…BPF in prenatal urine BPF in urine was analysed by LC/MS/MS at OEM in Lund, Sweden. 16 Briefly, 200 µl aliquots of urine were treated with β-glucoronidase (Escherichia coli), at 37°C for 30 min, thereafter labelled internal standard for BPF was added. In each analytical batch, calibration standards, a QC sample and chemical blank samples were included.…”

What's new for the clinician? - excerpts from and summaries of recently published papers

“…There is considerable concern among scientists and the public about the hormone-mimicking properties of many chemical components of plastics, including those found in dental composites 1 . The commonly used Bis-GMA resin uses one of the most controversial of these, Bisphenol-A (BPA).…”

“…Bisphenol A (BPA) is a synthetic chemical substance, produced in large quantities and widely used in the production of polycarbonate plastics, epoxy resins, dental monomers, thermal paper, and numerous other products. 1 Responsible composite manufacturers claim that there is no unreacted BPA in dental resins, and that it takes high temperatures -several hundred degrees -to liberate free BPA. Other critics say that, in fact, the ester bonds in resins are subject to hydrolysis, and BPA can be liberated in measurable quantities.…”

“…Other critics say that, in fact, the ester bonds in resins are subject to hydrolysis, and BPA can be liberated in measurable quantities. 1 BPA levels in human populations have been associated with reproductive abnormalities, adverse developmental effects, metabolic disease, and breast cancer, among other health conditions. 1 There is wide interest in the sources of BPA exposure.…”

“…1 BPA levels in human populations have been associated with reproductive abnormalities, adverse developmental effects, metabolic disease, and breast cancer, among other health conditions. 1 There is wide interest in the sources of BPA exposure. The primary source of human exposure is assumed to be through the diet because BPA can leach into food and beverages from containers made of polycarbonate plastic or lined with epoxy resin coatings.…”