Bisphenol A-induced metabolic disorders: From exposure to mechanism of action

Akash, Muhammad Sajid Hamid; Sabir, Shakila; Rehman, Kanwal

doi:10.1016/j.etap.2020.103373

Cited by 91 publications

(35 citation statements)

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“…This effect contributes to diminished insulin secretion and to the gradual failure of the insulin-secreting cells (Wei et al 2011 ). Moreover, BPA alters the expression of some genes in pancreatic β-cells, which is also associated with decreased insulin secretion (Akash et al 2020 ). This detrimental influence of BPA on β-cells additionally worsens the whole-body glucose homeostasis.…”

Section: Introductionmentioning

confidence: 99%

“…These adipokines have been implicated in the regulation of feeding behavior, energy expenditure, glucose homeostasis, and many more (Fietta and Delsante 2013 ). Results of rodent studies have shown that BPA disturbs the metabolism of adipose tissue and also affects blood adipokine levels (Angle et al 2013 ; Akash et al 2020 ; Haq et al 2020 ). Moreover, studies in vitro, on 3T3-L1 cells, have provided evidence that long-term exposure to BPA promotes adipogenesis.…”

Section: Introductionmentioning

confidence: 99%

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Bisphenol A disturbs metabolism of primary rat adipocytes without affecting adipokine secretion

Szkudelska

Okulicz

Szkudelski

2021

Environ Sci Pollut Res

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Bisphenol A (BPA) is an ubiquitous synthetic chemical exerting numerous adverse effects. Results of rodent studies show that BPA negatively affects adipose tissue. However, the short-term influence of this compound addressing adipocyte metabolism and adipokine secretion is unknown. In the present study, isolated rat adipocytes were exposed for 2 h to 1 and 10 nM BPA. Insulin-induced glucose conversion to lipids along with glucose transport was significantly increased in the presence of BPA. However, basal glucose conversion to lipids, glucose oxidation, and formation of lipids from acetate were unchanged in adipocytes incubated with BPA. It was also shown that BPA significantly increases lipolytic response of adipocytes to epinephrine. However, lipolysis stimulated by dibutyryl-cAMP (a direct activator of protein kinase A) and the antilipolytic action of insulin were not affected by BPA. Moreover, BPA did not influence leptin and adiponectin secretion from adipocytes. Our new results show that BPA is capable of disturbing processes related to lipid accumulation in isolated rat adipocytes. This is associated with the potentiation of insulin and epinephrine action. The effects of BPA appear already after short-term exposure to low doses of this compound. However, BPA fails to change adipokine secretion.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bisphenol A disturbs metabolism of primary rat adipocytes without affecting adipokine secretion

Szkudelska

Okulicz

Szkudelski

2021

Environ Sci Pollut Res

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“…PCOS is caused by many causes, including genetic, psychosocial factors, bad living habits and environmental factors (chemicals: pesticides, industrial pollutants; personal care products: perfumes, deodorants, hair dyes, perfume compounds and bisphenol A). The speci c etiology and pathogenesis of the disease are not currently clear [3][4][5][6]. Ovarian granulosa cells (GCs) have the function of secretion, which plays an important role in the process of folliculogenesis [7].…”

Section: Introductionmentioning

confidence: 99%

Key genes and pathways of ovarian granulosa cells in polycystic ovary syndrome identified by bioinformatics analysis

Liang¹,

Wang

2021

Preprint

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Purpose Polycystic ovary syndrome (PCOS) is one of the factors leading to infertility. The specific pathogenesis of PCOS is still unclear. The purpose of this study was to determine key changes in gene expression during the formation of PCOS and to provide a theoretical basis for the clinical diagnosis and treatment of PCOS. Methods We analyzed differentially expressed genes (DEGs) in the dataset GSE34526 from the bioinformatics array research tool (BART) online analysis tool (bart.salk.edu). Then, through the Database for Annotation, Visualization and Integrated Discovery (DAVID) (https://david.ncifcrf.gov/) online analysis software for gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) rich path analysis, STRING (https://string-db.org/) online analysis tool for protein-protein interaction (PPI) network, Cytoscape software for Mcode module and HUB gene analysis Results a total of 91 DEGs, 7 up-regulated and 84 down-regulated, were found. Seven central HUB genes were identified, including integrin alpha-M (ITGAM), cytochrome BMUR 245 beta chain (CYBB), toll like receptor 1 (TLR1), platelet activating factor receptor (PTAFR), CD163 molecule, caspase 1 (CASP1), and matrix metallopeptidase 9 (MMP 9). Conclusion the DEGs, HUB genes and signaling pathways identified in this study help us understand the molecular mechanism of PCOS formation and provide new targets for the diagnosis and treatment of PCOS.

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“…Bisphenol S (BPS), the predominant replacement chemical for BPA did not show any different effects compared to BPA (Ahmed & Atlas, 2016; Rochester & Bolden, 2015). Exposure to BPA during early human development is also reported to trigger many non‐communicable diseases such as hypertension, coronary heart disease, obesity, and diabetes mellitus, that emerge later in life (Akash, Sabir, & Rehman, 2020; Alonso‐Magdalena, Rivera, & Guerrero‐Bosagna, 2016).…”

Section: Introductionmentioning

confidence: 99%

Plastics derived endocrine‐disrupting compounds and their effects on early development

Basak

Das

Duttaroy

2020

Birth Defects Research

114

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Despite the fact that the estrogenic effects of bisphenols were first described 80 years ago, recent data about its potential negative impact on birth outcome parameters raises a strong rationale to investigate further. The adverse health effects of plastics recommend to measure the impacts of endocrine-disrupting compounds (EDCs) such as bisphenols (BPA, BPS, BPF), bis(2-ethylhexyl) phthalate, and dibutyl phthalate (DBP) in human health. Exposure to these compounds in utero may program the diseases of the testis, prostate, kidney and abnormalities in the immune system, and cause tumors, uterine hemorrhage during pregnancy and polycystic ovary. These compounds also control the processes of epigenetic transgenerational inheritance of adult-onset diseases by modulating DNA methylation and epimutations in reproductive cells. The early developmental stage is the most susceptible window for developmental and genomic programming. The critical stages of the events for a normal human birth lie between the many transitions occurring between spermatogenesis, egg fertilization and the fully formed fetus. As the cells begin to grow and differentiate, there are critical balances of hormones, and protein synthesis. Data are emerging on how these plastic-derived compounds affect embryogenesis, placentation and feto-placental development since pregnant women and unborn fetuses are often exposed to these factors during preconception and throughout gestation. Impaired early development that ultimately influences fetal outcomes is at the center of many developmental disorders and contributes an independent risk factor for adult chronic diseases. This review will summarize the current status on the impact of exposure to plastic derived

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Bisphenol A-induced metabolic disorders: From exposure to mechanism of action

Cited by 91 publications

References 167 publications

Bisphenol A disturbs metabolism of primary rat adipocytes without affecting adipokine secretion

Bisphenol A disturbs metabolism of primary rat adipocytes without affecting adipokine secretion

Key genes and pathways of ovarian granulosa cells in polycystic ovary syndrome identified by bioinformatics analysis

Plastics derived endocrine‐disrupting compounds and their effects on early development

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Bisphenol A-induced metabolic disorders: From exposure to mechanism of action

Cited by 91 publications

References 167 publications

Bisphenol A disturbs metabolism of primary rat adipocytes without affecting adipokine secretion

Bisphenol A disturbs metabolism of primary rat adipocytes without affecting adipokine secretion

Key genes and pathways of ovarian granulosa cells in polycystic ovary syndrome&nbsp;identified by bioinformatics analysis

Plastics derived endocrine‐disrupting compounds and their effects on early development

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Product

Resources

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Key genes and pathways of ovarian granulosa cells in polycystic ovary syndrome identified by bioinformatics analysis