Bisphenol S modulates concentrations of bisphenol A and oestradiol in female and male mice

Pollock, Tyler; Greville, Lucas J.; Weaver, Rachel E.; Radenovic, Marija; deCatanzaro, Denys

doi:10.1080/00498254.2018.1480818

Cited by 11 publications

(6 citation statements)

References 73 publications

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“…However, the similar BPA toxicokinetic results obtained in this study compared to previous work (Volkel et al, 2002;Doerge et al, 2010;Gayrard et al, 2013;Patterson et al, 2013;Thayer et al, 2015) suggest that co-exposure to other bisphenols did not interfere with BPF or BPA kinetics. Although, a recent study has demonstrated that the co-administration of BPA (oral, 50 µg/kg C 14 -BPA) with BPS (s.c. injections, 1, 3, 6, and 9 mg) results in elevated circulating levels of total BPA in mice at the 9 mg BPS dose (Pollock et al, 2018) and hypothesized that the BPA kinetics may be altered due to competition for metabolic enzymes, such as sulfotransferase (SULT) or UDP-glucuronosyltransferase (UGT) (Pollock et al, 2018).…”

Section: Maternal Toxicokinetics Of Bisphenolsmentioning

confidence: 99%

Toxicokinetics of bisphenol A, bisphenol S, and bisphenol F in a pregnancy sheep model

Gingrich¹,

Ehrhardt³

et al. 2019

Chemosphere

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Bisphenol A (BPA), S (BPS), and F (BPF) are among the most abundant bisphenols detected in humans, yet pregnancy toxicokinetics for BPS or BPF remain unknown. Because gestational BPS can disrupt placental function and result in reproductive and metabolic disorders in the progeny, the aim of the study was to investigate BPS and BPF toxicokinetics during pregnancy using an in vivo approach. Fetal catheterizations were conducted in pregnant sheep (n = 6) at mid-pregnancy and injected with either a single dose of BPS (n = 3, 0.5 mg/kg, s.c.), or a combination of BPS, BPF, and BPA (n = 3, 0.5 mg/kg for each chemical, s.c.). Maternal and fetal blood and urine and amniotic fluid were collected over 72h and analyzed for bisphenols by HPLC-MS/MS. We observed significant differences in half-life, maximum concentration, and total body clearance in maternal circulation among bisphenols. Longer half-lives were observed in fetal vs. maternal circulation for all bisphenols. Fetal toxicokinetics differed among bisphenols with BPS having the longest fetal half-life. All bisphenols reached basal levels at 48h in maternal plasma, but were still detectable in amniotic fluid, fetal urine, and fetal plasma at 72h. In this first pregnancy toxicokinetic study of BPS and BPF we have demonstrated maternal and fetal oxicokinetic differences among all three bisphenols. Higher BPS persistence in the fetal compartment warrants studies into progeny adverse outcomes following gestational exposure. Additionally, toxicokinetic

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Section: Maternal Toxicokinetics Of Bisphenolsmentioning

confidence: 99%

Toxicokinetics of bisphenol A, bisphenol S, and bisphenol F in a pregnancy sheep model

Gingrich¹,

Ehrhardt³

et al. 2019

Chemosphere

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“…The comprehensive work of T. Pollock and his colleagues produced valuable results, describing cross talk of common EDs. The combined presence of bisphenols is considered to be deleterious [95] as well as the simultaneous presence of triclosan, a soap compound [96,97]. Degradation of bisphenol is inhibited under other ED exposure, and, obviously, the co-exposure achieves various modes on how to affect the body [98].…”

Section: Molecular Mechanism Of Eds In Extremely Low Dosesmentioning

confidence: 99%

Endocrine Disruptors: Very Low Doses with Genuinely High Impacts on Male Reproduction

Ješeta¹,

Nevoral²

2020

Male Reproductive Health

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Endocrine disruptors (EDs) are chemical substances that affect physiological processes in the body via hormonal regulation. They are often detected in food, plastic water bottles, cosmetics, and many other daily need items. Thereafter, EDs are detected in many bodily fluids, pointing out the real exposure to even very low doses. Permanent and long-term utilization of EDs has harmful effects on male reproductive health mainly due to interference with sex hormone synthesis and mechanism of action. However, with decreasing dosage of EDs, the possibilities of unpredictable modes of action arise. In addition to various molecular actions of individual EDs, the interference of individual ones represents another dimension of the ED issue. This review provides an overview of the EDs and their possible impact on reproductive health in males, with focus on sperm quality with the mighty potential of epigenetic transmission to further generations. The "posttranslational" effect of EDs in really low doses in real exposure routes is stigmatized in this review, being strongly considered as creeping molecular action of individual EDs as well as amplifications of their copresence in the environment.

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“…Even a low dose of chronic exposure to bisphenols suppresses the luteinizing hormone, follicle-stimulating hormones, and prolactin, exhibiting estrogenic and antiandrogenic effects and affecting spermatogenesis [12,47,48]. Common reproductive abnormalities include premature puberty, ovarian dysfunction, implantation failure, abnormal sperm function, fertilization failure, sex hormone abnormality, premature birth, and lower birth weight [48][49][50][51][52]. Bisphenols interact with both membrane-bound and nuclear estrogen receptors.…”

Section: Endocrine Disruption and Reproductive Abnormalitiesmentioning

confidence: 99%

Bisphenols as a Legacy Pollutant, and Their Effects on Organ Vulnerability

Kim

Kumar

et al. 2019

IJERPH

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Bisphenols are widely used in the synthesis of polycarbonate plastics, epoxy resins, and thermal paper, which are used in manufacturing items of daily use. Packaged foods and drinks are the main sources of exposure to bisphenols. These chemicals affect humans and animals by disrupting the estrogen, androgen, progesterone, thyroid, and aryl hydrocarbon receptor functions. Bisphenols exert numerous harmful effects because of their interaction with receptors, reactive oxygen species (ROS) formation, lipid peroxidation, mitochondrial dysfunction, and cell signal alterations. Both cohort and case-control studies have determined an association between bisphenol exposure and increased risk of cardiovascular diseases, neurological disorders, reproductive abnormalities, obesity, and diabetes. Prenatal exposure to bisphenols results in developmental disorders in animals. These chemicals also affect the immune cells and play a significant role in initiating the inflammatory response. Exposure to bisphenols exhibit age, gender, and dose-dependent effects. Even at low concentrations, bisphenols exert toxicity, and hence deserve a critical assessment of their uses. Since bisphenols have a global influence on human health, the need to discover the underlying pathways involved in all disease conditions is essential. Furthermore, it is important to promote the use of alternatives for bisphenols, thereby restricting their uses.

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Bisphenol S modulates concentrations of bisphenol A and oestradiol in female and male mice

Cited by 11 publications

References 73 publications

Toxicokinetics of bisphenol A, bisphenol S, and bisphenol F in a pregnancy sheep model

Toxicokinetics of bisphenol A, bisphenol S, and bisphenol F in a pregnancy sheep model

Endocrine Disruptors: Very Low Doses with Genuinely High Impacts on Male Reproduction

Bisphenols as a Legacy Pollutant, and Their Effects on Organ Vulnerability

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