Bisphenols S and F drive ovarian granulosa cell tumor invasion via a metabolic switch

Gogola-Mruk, Justyna; Krawczyk, Kinga; Marynowicz, Weronika; Rokita, M.; Nimpsz, Samantha; Ptak, Anna

doi:10.1016/j.toxlet.2022.12.011

Cited by 6 publications

(1 citation statement)

References 35 publications

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“…However, few people pay attention to 2,2'-BPF and 2,4'-BPF (Guo et al, 2019;Sun et al, 2017) . Due to the structural similarity between 4,4'-BPF and BPS and BPA, BPS and 4,4'-BPF were found to have the same potency in inhibitory hormone signaling as BPA (Gogola−Mruk et al, 2023;Le Fol et al, 2017;Wang et al, 2021) . The high use of bisphenol analogs has led to their high detection frequency in various environmental media (Gao et al, 2023;Maturi et al, 2023;Qian et al, 2021;Xue et al, 2016) .…”

Section: Introductionmentioning

confidence: 99%

Transport of bisphenol A, bisphenol S, and three bisphenol F isomers in saturated soils

Zi,

Xu,

Zhang

et al. 2023

Environ Sci Pollut Res

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With the limitation of the use of bisphenol A (BPA), the production of its substitutes, bisphenol S (BPS) and bisphenol F (4,4'-BPF) is increasing. Understanding the fate and transport of BPA and its substitutes in porous media can help reduce their risk of contaminating soil and groundwater systems. In this study, column and batch adsorption experiments were performed with 14 C-labeled bisphenol analogs and combined with mathematical models to investigate the interaction of BPA, BPS, 4,4'-BPF, 2,2'-BPF and 2,4'-BPF with four standard soils with different soil organic matter (SOM) contents. The results show that the transport capacity of BPS and 4,4'-BPF in the saturated soils is signi cantly stronger than that of BPA. Meanwhile, the mobility of the three isomers of bisphenol F (2,2'-BPF, 2,4'-BPF and 4,4'-BPF) showed some variability in saturated soils with high SOM content. The two-site kinetic retention mode was applied to simulate and interpret experimental data, and model simulations described the interactions between the bisphenol analogs and soil very well. The tting results show that SOM provides more adsorption sites for bisphenol analogs and these adsorption sites may be irreversible adsorption sites. For the different mobility of bisphenol analogs, hydrophobicity is the main factor leading to the difference in adsorption a nity between BPA, BPS, 4,4'-BPF and soil. The main factor leading to the difference of adsorption a nity between 4,4'-BPF and its isomers (2,2'-BPF and 2,4'-BPF) and soil may be hydrogen bonding force. In addition, the results of this study show that the relatively high mobility of BPA substitutes BPS and 4,4'-BPF may pose a signi cant risk to groundwater quality, so 4,4'-BPF and BPS may not be environmentally friendly alternatives to BPA. In addition, as by-products of 4,4'-BPF production, 2,2'-BPF and 2,4'-BPF have high mobility in soil and may pose a more signi cant threat to groundwater than 4,4'-BPF. HighlightsBPS and 4,4'-BPF has higher mobility than BPA in four standard soils.2,2'-BPF, 2,4'-BPF and 4,4'-BPF have different transport capacities in standard soils.The adsorption a nity of bisphenol analogs to soil is signi cantly correlated with soil organic matter.

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