Bisphosphonate-functionalized coordination polymer nanoparticles for the treatment of bone metastatic breast cancer

He, Yuanfeng; Huang, Yanjuan; Huang, Ziyuan; Jiang, Yali; Sun, Xiaoqi; Shen, Yifeng; Chu, Weijing; Zhao, Chunshun

doi:10.1016/j.jconrel.2017.08.024

Cited by 68 publications

(33 citation statements)

References 44 publications

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“…Thus, ZOL can also be employed as a target factor for bone. Moreover, bisphosphonate-coated PLGA NPs can improve therapeutic efficacy by targeting bone, as shown in previous studies 41 – 43 . However, to the best of our knowledge, a nanotherapeutic system that is based on magnetically and photothermally triggered ICG@PLGA NPs and targets against BM of breast cancer has been rarely reported.…”

Section: Introductionsupporting

confidence: 55%

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Zoledronate and SPIO dual-targeting nanoparticles loaded with ICG for photothermal therapy of breast cancer tibial metastasis

Jiang

Chen

et al. 2020

Sci Rep

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Currently, nanoparticles (NPs) for cancer photothermal therapy (PTT) have limited in vivo clearance, lack targeting ability and have unsatisfactory therapeutic efficiency. Herein, we report a dual-targeting and photothermally triggered nanotherapeutic system based on superparamagnetic iron oxide (Fe 3 O 4 ) and indocyanine green (ICG)-entrapped poly-lactide-co-glycolide modified by ZOL (PLGA-ZOL) NPs (ICG/Fe 3 O 4 @PLGA-ZOL) for PTT of breast cancer tibial metastasis, which occurs frequently in the clinic and causes challenging complications in breast cancer. In this system, both ICG and Fe 3 O 4 can convert light into heat, while NPs with Fe 3 O 4 and ZOL can be attracted to a specific location in bone under an external magnetic field. Specifically, the dual-targeting and double photothermal agents guaranteed high accumulation in the tibia and perfect PTT efficiency. Furthermore, the in vivo studies showed that ICG/Fe 3 O 4 @PLGA-ZOL NPs have extraordinary antitumor therapeutic effects and that these NPs can be accurately located in the medullary cavity of the tibia to solve problems with deep lesions, such as breast cancer tibial metastasis, showing great potential for cancer theranostics.

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Section: Introductionsupporting

confidence: 55%

“…The BALB/c mice (female, aged 6 weeks, 20–25 g) were intra-tibially injected with the 4T1 breast cancer cells using an assay that was proven by preceding research 43 , 50 . First, the mice were anesthetized by intraperitoneal injection of 0.06 ml pentobarbital sodium at a w/v ratio of 2.5%.…”

Section: Methodsmentioning

confidence: 99%

Zoledronate and SPIO dual-targeting nanoparticles loaded with ICG for photothermal therapy of breast cancer tibial metastasis

Jiang

Chen

et al. 2020

Sci Rep

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“…Many attempts have been centered on NP drug delivery systems, like HA NPs, liposomes, and micelles, with the aim of increasing their permeability to the blood-bone marrow barrier and the retention time. For example, in a recent study (2017), some researchers developed water-in-oil (W/O) microemulsion in which a cisplatin prodrug (DSP) was included in polymer nanoparticles (CPNs) functionalized with alendronate (ALN) to obtain a selective accumulation in the bone metastatic lesion and a prolonged drug circulation time [65].…”

Section: Bone Metastasesmentioning

confidence: 99%

Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics

et al. 2020

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Bone diseases include a wide group of skeletal-related disorders that cause mobility limitations and mortality. In some cases, e.g., in osteosarcoma (OS) and metastatic bone cancer, current treatments are not fully effective, mainly due to low patient compliance and to adverse side effects. To overcome these drawbacks, nanotechnology is currently under study as a potential strategy allowing specific drug release kinetics and enhancing bone regeneration. Polymers, ceramics, semiconductors, metals, and self-assembled molecular complexes are some of the most used nanoscale materials, although in most cases their surface properties need to be tuned by chemical or physical reactions. Among all, scaffolds, nanoparticles (NPs), cements, and hydrogels exhibit more advantages than drawbacks when compared to other nanosystems and are therefore the object of several studies. The aim of this review is to provide information about the current therapies of different bone diseases focusing the attention on new discoveries in the field of targeted delivery systems. The authors hope that this paper could help to pursue further directions about bone targeted nanosystems and their application for bone diseases and bone regeneration.

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“…In these systems, the use of precise biomolecules for improving the nanoparticles accumulation in the site of action has allowed the efficient delivery of therapeutics. Zhao and coworkers designed a cisplatin prodrug bearing Zn-based NCPs, which were coated with polyethylene glycol (PEG) and decorated with alendronate (ALN), which is a bone-seeking moiety [68]. The resulting nanoformulation showed much higher affinity for hydroxyapatite in vitro and bone in vivo than non-targeted nanoparticles.…”

Section: Platinum-based Ncpsmentioning

confidence: 99%

Design of Targeted Nanostructured Coordination Polymers (NCPs) for Cancer Therapy

Novio

2020

Molecules

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Conventional cancer chemotherapy presents notable drug side effects due to non-selective action of the chemotherapeutics to normal cells. Nanoparticles decorated with receptor-specific ligands on the surface have shown an important role in improving site-selective binding, retention, and drug delivery to the cancer cells. This review summarizes the recent reported achievements using nanostructured coordination polymers (NCPs) with active targeting properties for cancer treatment in vitro and in vivo. Despite the controversy surrounding the effectivity of active targeting nanoparticles, several studies suggest that active targeting nanoparticles notably increase the selectivity and the cytotoxic effect in tumoral cells over the conventional anticancer drugs and non-targeted nanoparticle platform, which enhances drug efficacy and safety. In most cases, the nanocarriers have been endowed with remarkable capabilities such as stimuli-responsive properties, targeting abilities, or the possibility to be monitored by imaging techniques. Unfortunately, the lack of preclinical studies impedes the evaluation of these unique and promising findings for the translation of NCPs into clinical trials.

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Bisphosphonate-functionalized coordination polymer nanoparticles for the treatment of bone metastatic breast cancer

Cited by 68 publications

References 44 publications

Zoledronate and SPIO dual-targeting nanoparticles loaded with ICG for photothermal therapy of breast cancer tibial metastasis

Zoledronate and SPIO dual-targeting nanoparticles loaded with ICG for photothermal therapy of breast cancer tibial metastasis

Bone Diseases: Current Approach and Future Perspectives in Drug Delivery Systems for Bone Targeted Therapeutics

Design of Targeted Nanostructured Coordination Polymers (NCPs) for Cancer Therapy

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