Bisphosphonate-related osteonecrosis induced change in alveolar bone architecture in rats with participation of Wnt signaling

Ferreira, Vanessa Costa de Sousa; Lopes, Amanda P.; Alves, Nicholas Militão; Sousa, Fátima Regina Nunes de; Pereira, Karuza Maria Alves; Gondim, Delane Viana; Girão-Carmona, Virgínia Cláudia Carneiro; Leitão, Renata F. C.; Góes, Paula

doi:10.1007/s00784-020-03551-7

Cited by 20 publications

(25 citation statements)

References 40 publications

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“…The model was installed on the working platform. The measuring pin of the device was fixed at its lowest position, and with the help of the regulator, the zero position was set on the scoreboard ( Batas et al, 2020 , De Sousa Ferreira et al, 2021 ). Then, using the screw, the bracket was lowered so that the measuring pin touched the corresponding marking on the transitional fold.…”

Section: Methodsmentioning

confidence: 99%

Influence of direct prostheses on the condition of the alveolar processes during dental implantation

Shuturminskiy

Labunets

Kirichek

2022

The Saudi Dental Journal

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Objective The purpose of this article is to study of the processes accompanying osseointegration of the dental implants using various plate prostheses as temporary constructions, as well as to compare the dynamics of changes in the state of the jaw alveolar processes. Materials and methods The effect of dentures on the condition of the alveolar processes was studied in all patients according to the technique developed by L. Chulak on the 7th, 14th, 30th day and in 3, 6 months. To verify the results, the degree of atrophy of the alveolar processes was also determined by the second method the authors have chosen at the same time as indicated above. Results The measurement results confirm linear changes in the height of the alveolar processes of the jaws with a decrease in the tissues of the prosthetic area. Throughout the duration of the examination, atrophy of the tissues of the alveolar processes is observed. Judging by the results obtained during the patients’ study, it can be concluded that when applied as a temporary prosthesis with a dental delayed implantation of a partial denture made of polypropylene, the results of the state of the hard tissues of the mandible alveolar process show a better adaptation of the mucous membrane and slowing of atrophy of the jaw alveolar processes with this type of prosthetics.

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Section: Methodsmentioning

confidence: 99%

Influence of direct prostheses on the condition of the alveolar processes during dental implantation

Shuturminskiy

Labunets

Kirichek

2022

The Saudi Dental Journal

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“…Wnt3a may weaken the osteogenesis inhibition effect of pamidronate disodium on BMMSCs (Y. Xu et al, 2017). de Sousa Ferreira et al (2020) also found that zoledronate‐mediated osteonecrosis may be an important mechanism by inhibiting the canonical Wnt signalling pathway. The current research mainly focuses on the role of the canonical Wnt signalling pathway in BRONJ, while the role of the noncanonical Wnt signalling pathway needs to be further studied, as shown in Figure 6.…”

Section: Wnt and Other Diseasesmentioning

confidence: 97%

Wnt signalling in oral and maxillofacial diseases

Zhang

Pan

Chen

et al. 2021

Cell Biology International

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Wnts include more than 19 types of secreted glycoproteins that are involved in a wide range of pathological processes in oral and maxillofacial diseases. The transmission of Wnt signalling from the extracellular matrix into the nucleus includes canonical pathways and noncanonical pathways, which play an important role in tooth development, alveolar bone regeneration, and related diseases. In recent years, with the in‐depth study of Wnt signalling in oral and maxillofacial‐related diseases, many new conclusions and perspectives have been reached, and there are also some controversies. This article aims to summarise the roles of Wnt signalling in various oral diseases, including periodontitis, dental pulp disease, jaw disease, cleft palate, and abnormal tooth development, to provide researchers with a better and more comprehensive understanding of Wnts in oral and maxillofacial diseases.

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“…In summary, the dosage of ZA ranges from 0.0075 to 2.25 mg·kg −1 , with the most commonly used drug regimen being 0.1 mg·kg −1 ZA thrice a week for 6–9 weeks through intraperitoneal injection 47 , 55 – 58 . In addition, some studies used a corticosteroid drug such as DEX with BPs to increase the prevalence of osteonecrosis.…”

Section: Approaches Of Establishing Mronj Modelsmentioning

confidence: 99%

“… TEM 106 To illustrate osteoclasts with ruffled border adjacent to the alveolar wall. Raman spectroscopy 47 To calculate mineral/matrix ratio and carbonate/phosphate. ICG-based NIF imaging 89 To mark affected bone tissues with pathological examination with quantification detection of fluorescence intensity.…”

Section: Assessment Of Mronj-like Lesions In Rodent Modelsmentioning

confidence: 99%

“…Mucosal healing and bone exposure are two important indexes in gross observation. Most studies mainly describe the gross MRONJ as “incomplete and delayed mucosal healing and bone exposure” 30 , 44 , 45 , 47 , 62 , 64 , 67 , 72 , 93 – 96 . However, in infection-induced MRONJ rodent models, the gross observation may only present mild to moderate inflammation with soft tissue swelling and erythema without exposure to bone tissue on probing 45 , 85 .…”

Section: Assessment Of Mronj-like Lesions In Rodent Modelsmentioning

confidence: 99%

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Establishment and assessment of rodent models of medication-related osteonecrosis of the jaw (MRONJ)

Yan

Jiang

et al. 2022

Int J Oral Sci

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Medication-related osteonecrosis of the jaw (MRONJ) is primarily associated with administering antiresorptive or antiangiogenic drugs. Despite significant research on MRONJ, its pathogenesis and effective treatments are still not fully understood. Animal models can be used to simulate the pathophysiological features of MRONJ, serving as standardized in vivo experimental platforms to explore the pathogenesis and therapies of MRONJ. Rodent models exhibit excellent effectiveness and high reproducibility in mimicking human MRONJ, but classical methods cannot achieve a complete replica of the pathogenesis of MRONJ. Modified rodent models have been reported with improvements for better mimicking of MRONJ onset in clinic. This review summarizes representative classical and modified rodent models of MRONJ created through various combinations of systemic drug induction and local stimulation and discusses their effectiveness and efficiency. Currently, there is a lack of a unified assessment system for MRONJ models, which hinders a standard definition of MRONJ-like lesions in rodents. Therefore, this review comprehensively summarizes assessment systems based on published peer-review articles, including new approaches in gross observation, histological assessments, radiographic assessments, and serological assessments. This review can serve as a reference for model establishment and evaluation in future preclinical studies on MRONJ.

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Bisphosphonate-related osteonecrosis induced change in alveolar bone architecture in rats with participation of Wnt signaling

Cited by 20 publications

References 40 publications

Influence of direct prostheses on the condition of the alveolar processes during dental implantation

Influence of direct prostheses on the condition of the alveolar processes during dental implantation

Wnt signalling in oral and maxillofacial diseases

Establishment and assessment of rodent models of medication-related osteonecrosis of the jaw (MRONJ)

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