Bisphosphonates vs Exercise for the Prevention and Treatment of Osteoporosis

Hurley, Ben F.; Armstrong, T

doi:10.1016/j.nurpra.2011.07.029

Cited by 8 publications

(2 citation statements)

References 48 publications

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“…Exercises improve the ratio of bone formation to resorption and improve bone structure by preserving trabecular and cortical structure, increasing thickness of cortical tissue, and improving bone geometry and microarchitecture (Rizzoli, 2018). There are many other positive effects for postmenopausal women who exercise, including increased insulin sensitivity, improved balance, gait, and muscle strength, and decreased risk of falls and depression (Benedetti et al, 2018; Hurley & Armstrong, 2012; Varahra et al, 2018).…”

Section: Background and Significancementioning

confidence: 99%

Promoting adherence to bone-loading exercises in postmenopausal women with low bone mass

Waltman

Cole

Kupzyk

et al. 2021

J Am Assoc Nurse Pract

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Background: We recently completed a parent study (Bone Loading Exercises versus Risedronate on Bone Health in Post-menopausal Women [NIH# R01NR015029]) examining bone-loading exercises to prevent bone loss in postmenopausal women with low bone mass. Forty-three million US women have low bone mass and increased risk for fractures. Bone-loading exercises (weight-bearing and resistance training) can preserve bone mass and decrease risk of fractures. However, multiple barriers prevent women from exercising and adherence rates are low. Purpose: This secondary analysis of the parent study (a) examined barriers specific to women participating in bone-loading exercises; (b) described effectiveness of self-efficacy strategies used in the parent study for increasing confidence in knowledge and reducing barriers; and (c) applied study findings and principles of self-efficacy and self-regulation in development of guidelines for promoting adherence to exercises. Methods: Seventy-two women were randomized to the exercise group and completed 12 months of exercises. Instruments for self-efficacy were completed at 2 weeks and barriers interference at 6 months. Percent adherence was measured as the number of exercise sessions attended divided by the number prescribed. Results: In the 12-month study, average adherence to exercises was 58.9%. Lower adherers reported lack of self-regulation skills such as “lack of time” as the most frequent barriers to exercise. Implications for practice: Guidelines developed included promotion of skills for self-regulation (such as regulation of time) as well as self-efficacy to improve adherence rates. Nurse practitioners may be the most motivated of all providers to use guidelines promoting exercise for women in their clinical practice.

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Section: Background and Significancementioning

confidence: 99%

Promoting adherence to bone-loading exercises in postmenopausal women with low bone mass

Waltman

Cole

Kupzyk

et al. 2021

J Am Assoc Nurse Pract

View full text Add to dashboard Cite

show abstract

“…2 Regular exercise has been shown to have a significant beneficial effect in the treatment of osteoporosis. 3 In general, mechanical loading regulates bone homeostasis through its direct effects on bone formation and remodeling. Bone responds to weight bearing by mineralization and to immobilization by demineralization.…”

Section: Introductionmentioning

confidence: 99%

Cyclic Tensile Strain Enhances Osteogenesis and Angiogenesis in Mesenchymal Stem Cells from Osteoporotic Donors

Charoenpanich

Wall

Tucker

et al. 2014

Tissue Engineering Part A

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We have shown that the uniaxial cyclic tensile strain of magnitude 10% promotes and enhances osteogenesis of human mesenchymal stem cells (hMSC) and human adipose-derived stem cells (hASC) from normal, nonosteoporotic donors. In the present study, MSC from osteoporotic donors were analyzed for changes in mRNA expression in response to 10% uniaxial tensile strain to identify potential mechanisms underlying the use of this mechanical loading paradigm for prevention and treatment of osteoporosis. Human MSC isolated from three female, postmenopausal osteoporotic donors were analyzed for their responses to mechanical loading using microarray analysis of over 47,000 gene probes. Human MSC were seeded in three-dimensional collagen type I constructs to mimic the organic extracellular matrix of bone and 10% uniaxial cyclic tensile strain was applied to promote osteogenesis. Seventy-nine genes were shown to be regulated within hMSC from osteoporotic donors in response to 10% cyclic tensile strain. Upregulation of six genes were further confirmed with real-time RT-PCR: jun D proto-oncogene (JUND) and plasminogen activator, urokinase receptor (PLAUR), two genes identified as potential key molecules from network analysis; phosphoinositide-3-kinase, catalytic, delta polypeptide (PIK3CD) and wingless-type MMTV integration site family, member 5B (WNT5B), two genes with known importance in bone biology; and, PDZ and LIM domain 4 (PDLIM4) and vascular endothelial growth factor A (VEGFA), two genes that we have previously shown are significantly regulated in hASC in response to this mechanical stimulus. Function analysis indicated that 10% cyclic tensile strain induced expression of genes associated with cell movement, cell proliferation, and tissue development, including development in musculoskeletal and cardiovascular systems. Our results demonstrate that hMSC from aged, osteoporotic donors are capable of enhanced osteogenic differentiation in response to 10% cyclic tensile strain with significant increases in the expression of genes associated with enhanced cell proliferation, musculoskeletal development, and angiogenesis. Surprisingly, cyclic tensile strain of magnitude 10% not only enhanced osteogenesis in hMSC from osteoporotic donors, but also enhanced expression of angiogenic factors. Better understanding and methodologies to promote osteogenesis in hMSC from elderly, osteoporotic donors may greatly facilitate achieving long-term success in bone regeneration and functional bone tissue engineering for this ever-growing patient population.

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Introduction to Exercise Physiology

Saghiv

Sagiv

2020

Basic Exercise Physiology

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Bisphosphonates vs Exercise for the Prevention and Treatment of Osteoporosis

Cited by 8 publications

References 48 publications

Promoting adherence to bone-loading exercises in postmenopausal women with low bone mass

Promoting adherence to bone-loading exercises in postmenopausal women with low bone mass

Cyclic Tensile Strain Enhances Osteogenesis and Angiogenesis in Mesenchymal Stem Cells from Osteoporotic Donors

Introduction to Exercise Physiology

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