2000
DOI: 10.1097/00000539-200010000-00019
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Bisulfite-Containing Propofol: Is it a Cost-Effective Alternative to Diprivan™ for Induction of Anesthesia?

Abstract: Bisulfite-containing propofol and Diprivan(TM) (AstraZeneca, Wilmington, DE) were similar with respect to their induction characteristics; however, the generic formulation was associated with a smaller incidence of injection pain. Assuming that the drug costs are similar, these data suggest that the bisulfite-containing formulation of propofol is a cost-effective alternative to Diprivan(TM).

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Cited by 26 publications
(10 citation statements)
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“…In a study examining the effect of propofol at induction of anaesthesia, pain on i.v. injection was observed to be less with generic propofol compared to Diprivan ® (5% vs. 11%) with no difference in hypnotic effect [6]. Inadvertent arterial injection has however been reported to cause hyperaemia and pain but onset of action seem to be similar to the i.v.…”
Section: Discussionmentioning
confidence: 90%
“…In a study examining the effect of propofol at induction of anaesthesia, pain on i.v. injection was observed to be less with generic propofol compared to Diprivan ® (5% vs. 11%) with no difference in hypnotic effect [6]. Inadvertent arterial injection has however been reported to cause hyperaemia and pain but onset of action seem to be similar to the i.v.…”
Section: Discussionmentioning
confidence: 90%
“…There is a report that propofol is contraindicated in patients with known allergy to muscle relaxants. (19) CONCLUSIONS Propofol (Diprivan) is a useful and safe medication to use by infusion. The use of generic propofol is contraindicated in patients allergic to sulfa.…”
Section: Discussionmentioning
confidence: 99%
“…(17) Although generic propofol may be slightly more cost effective than Diprivan, the risk of sulfa allergy and patient safety should be taken into account. (18,19) …”
Section: Allergic Reactionmentioning
confidence: 99%
“…Reports of pain on injection are varied and are often attributed to many different factors, including the size of the vein used for injection, pretreatment with local anesthetics or other drugs, injection technique, temperature of the dose, and formulation, among others [1,2]. Differences between brand and generic versions [4] and the excipients used (pure long-chain triglycerides or mixtures of medium-and long-chain triglycerides) [5] are among the formulation considerations that potentially influence the pain that patients often experience with a propofol injection.…”
Section: Introductionmentioning
confidence: 99%