Bivalent transition metal complexes of coumarin-3-yl thiosemicarbazone derivatives: Spectroscopic, antibacterial activity and thermogravimetric studies

Refat, Moamen S.; El‐Deen, Ibrahim M.; Anwer, Zeinab M.; El-Ghol, Samir

doi:10.1016/j.molstruc.2008.10.059

Cited by 101 publications

(27 citation statements)

References 40 publications

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“…Disappearance of this band in all the hybrid derivatives indicated deprotonation of the phenolic OH and involvement of the oxygen atom in bonding. Presence of coordinated water molecules in the metal organic hybrids was indicated by a band around 3502-3303 cm -1 and also by the bands in the range 850-873 cm -1 which indicated binding of water molecules to the metal ions 9 . Phenolic C-O stretching frequency 10 of TBAP was observed at 1251 cm -1 .…”

Section: Infrared Spectramentioning

confidence: 98%

Synthesis, Characterization, Chemical Nuclease Activity and Antimicrobial Evaluation of Tridentate (NOS Donor) Schiff Base Ligand: 2-(4-(Thiophen-2-yl)but-3-en-2-ylideneamino)phenol and their Metal-Organic Hybrids

2017

Chem Sci Trans

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Cu(II), Co(II), Ni(II) and Zn(II) metal-organic hybrids of new tridentate (NOS donor) Schiff base ligand derived from 4-(thiophen-2-yl)but-3-en-2-one (TB) and 2-aminophenol (AP) were synthesized, characterized and their pharmacological activities were evaluated. Possible geometry of the hybrid derivatives and the chelating atoms were investigated on the source of elemental analysis, magnetic moment, molar conductivity, infrared, EPR, NMR, electronic and mass spectral studies. The results were consistent with a three coordination environment around the metal ion. Synthesized compounds were screened for in vitro antimicrobial activity against bacteria Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia, Staphylococcus aureus, Staphylococcus saprophyticus and fungi Candida albicans. Hybrid derivatives showed improved antibacterial and antifungal activity compared with the ligand 2(-4-(thiophen-2-yl)but-3-en-2-ylidene amino)phenol (TBAP). DNA cleavage experiments done by means of gel electrophoresis with corresponding hybrid derivatives in the presence of H 2 O 2 showed pronounced discernible DNA cleavage.

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Section: Infrared Spectramentioning

confidence: 98%

Synthesis, Characterization, Chemical Nuclease Activity and Antimicrobial Evaluation of Tridentate (NOS Donor) Schiff Base Ligand: 2-(4-(Thiophen-2-yl)but-3-en-2-ylideneamino)phenol and their Metal-Organic Hybrids

2017

Chem Sci Trans

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“…The activation energies of decomposition were found to be in the range 125-181 kJ mol −1 . The high values of the activation energies reflect the thermal stability of the complexes [40][41][42][43][44]. The entropy of activation was found to have negative values in all the complexes which indicate that the decomposition reactions proceed with a lower rate than the normal ones.…”

Section: Thermal Analysesmentioning

confidence: 99%

Synthesis, Spectroscopic Interpretations, and Antioxidant Efficiency of Two Vital Selenium Complexes

Al-Khodir

2017

Acta Phys. Pol. A

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This paper aimed to synthesis, spectroscopic characterizations, and antioxidant assessment of two new selenium complexes with nicotinamide (Nic) and riboflavin (RF) as drug chelates. The speculated structures of the synthetic selenium complexes have been discussed by using different tools of spectroscopic analyses like infrared, the Raman, electronic, 1 H-NMR, and mass. Accordingly, the Fourier transform infrared and 1 H-NMR spectra, the mode of complexation is supported, as four molecules of nicotinamide drug act as a monodentate chelate through the Natom of the pyridine ring with [Se(Nic)4]·H2O formula. The two riboflavin drug molecules coordinated to selenium metal as a bidentate chelate through azomethine nitrogen of pyrazine ring and O-atom of C=O pyrimidine-2,4-dione group with general formula [Se(RF)2]. Both of Nic and RF chelates act as neutral charge ligands. The conductivity measurements indicated that the selenium complexes are non-electrolytes behaviors. Thermal analyses (thermal gravimetric-differential thermal analysis) of the studied complexes show that the decomposition process takes place in one broadening step with a wide temperature range. The surface morphology of the mentioned complexes was studied by scanning electron microscope and the particle size is calculated using X-ray powder diffraction. Thermodynamic kinetic parameters are calculated by using the Coats and Redfern equation. Screening of antioxidant activities of selenium complexes in vitro are assessed. The antioxidant activity is studied by three methods (DPPH assay, β-carotene/linoleic acid bleaching assay, and ferric reducing power assay), the studied complexes have a significant antioxidant activity compared to synthetic antioxidants like trolox and BHT.

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“…An inhibition zone diameter over 7 mm indicates that the ligand and its phenyltin complex are active against all bacteria under investigation [45]. Compound 1 exhibits moderate activity only in high concentration.…”

Section: Antibacterial Studiesmentioning

confidence: 99%

“…Complex 3 exhibit more inhibitory effects than the parent ligand, while almost no antibacterial effect was observed for complex 2. More inhibitory effects of 3 than the parent ligand may be due to electron delocalization over the whole chelate ring which increases the lipophilicity of molecule (chelation theory) [45,[47][48][49] and also because of the biological activity effects of diphenyltin moiety. The higher activity of diphenyltin than dimethyltin complex may also be attributed to the lipophilicity increased by the presence of two phenyl groups [50].…”

Section: Antibacterial Studiesmentioning

confidence: 99%

Diorganotin(IV) complexes with 2-furancarboxylic acid hydrazone derivative of benzoylacetone: Synthesis, X-ray structure, antibacterial activity, DNA cleavage and molecular docking

Sedaghat

Ebrahimi

Carlucci

et al. 2015

Journal of Organometallic Chemistry

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Bivalent transition metal complexes of coumarin-3-yl thiosemicarbazone derivatives: Spectroscopic, antibacterial activity and thermogravimetric studies

Cited by 101 publications

References 40 publications

Synthesis, Characterization, Chemical Nuclease Activity and Antimicrobial Evaluation of Tridentate (NOS Donor) Schiff Base Ligand: 2-(4-(Thiophen-2-yl)but-3-en-2-ylideneamino)phenol and their Metal-Organic Hybrids

Synthesis, Characterization, Chemical Nuclease Activity and Antimicrobial Evaluation of Tridentate (NOS Donor) Schiff Base Ligand: 2-(4-(Thiophen-2-yl)but-3-en-2-ylideneamino)phenol and their Metal-Organic Hybrids

Synthesis, Spectroscopic Interpretations, and Antioxidant Efficiency of Two Vital Selenium Complexes

Diorganotin(IV) complexes with 2-furancarboxylic acid hydrazone derivative of benzoylacetone: Synthesis, X-ray structure, antibacterial activity, DNA cleavage and molecular docking

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