Biventricular Implantable Cardioverter Defibrillators Improve Survival Compared with Biventricular Pacing Alone in Patients with Severe Left Ventricular Dysfunction

Ermis, Cengiz; Lurie, Keith G.; Zhu, Alan X.; Collins, Joanne; VanHeel, Laura; Sakaguchi, Scott; Lü, Fei; Pham, Scott; Benditt, David G.

doi:10.1046/j.1540-8167.2004.04044.x

Cited by 17 publications

(25 citation statements)

References 28 publications

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“…Although there is no randomized trial comparing CRT-P and ICD alone, the results of COMPANION and nonrandomized studies suggest an incremental survival benefit conferred by CRT-D compared with CRT pacing alone. 114,115 The incremental effect of CRT in patients with cardiomyopathy and dyssychrony above ICD therapy alone was tested in 3 major trials of mild (class I/II), moderate (class II/III), and severe (class III/IV) HF. Multicenter InSync Randomized Clinical Evaluation-ICD (MIRACLE-ICD) randomized 369 patients with class III and IV HF to ICD therapy alone or CRT-D and demonstrated improvement in functional status, exercise capacity, and quality of life with CRT-D at 6 months; however, no improvement in survival and rates of hospitalization were observed.…”

Section: Cardiac Resynchronization Therapymentioning

confidence: 99%

Clinical Management and Prevention of Sudden Cardiac Death

Yousuf

Chrispin

Tomaselli

et al. 2015

Circulation Research

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Despite the revolutionary advancements in the past 3 decades in the treatment of ventricular tachyarrhythmias with device-based therapy, sudden cardiac death (SCD) remains an enormous public health burden. Survivors of SCD are generally at high risk for recurrent events. The clinical management of such patients requires a multidisciplinary approach from postresuscitative care to a thorough cardiovascular investigation in an attempt to identify the underlying substrate, with potential to eliminate or modify the triggers through catheter ablation and ultimately an implantable cardioverter-defibrillator (ICD) for prompt treatment of recurrences in those at risk. Early recognition of low left ventricular ejection fraction as a strong predictor of death and association of ventricular arrhythmias with sudden death led to significant investigation with antiarrhythmic drugs. The lack of efficacy and the proarrhythmic effects of drugs catalyzed the development and investigation of the ICD through several major clinical trials that proved the efficacy of ICD as a bedrock tool to detect and promptly treat life-threatening arrhythmias. The ICD therapy is routinely used for primary prevention of SCD in patients with cardiomyopathy and high risk inherited arrhythmic conditions and secondary prevention in survivors of sudden cardiac arrest. This compendium will review the clinical management of those surviving SCD and discuss landmark studies of antiarrhythmic drugs, ICD, and cardiac resynchronization therapy in the primary and secondary prevention of SCD.

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Section: Cardiac Resynchronization Therapymentioning

confidence: 99%

Clinical Management and Prevention of Sudden Cardiac Death

Yousuf

Chrispin

Tomaselli

et al. 2015

Circulation Research

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“…Seven previously published meta-analyses were also identified [4, 5,11,12,13,14,15]. Compared to the previous meta-analyses, the current one became updated with three new published studies [6,7,8]. …”

Section: Resultsmentioning

confidence: 99%

“…All the 20 trials were randomized except two [7, 8]. Characteristics of the included studies and number of participants are shown in table 1.…”

Section: Resultsmentioning

confidence: 99%

“…It is also debated whether patients with LVSD should be routinely offered prophylactic ICD and whether a CRT-ICD should be the choice in some selective patients. Several recent studies have been published [6,7,8] and a revision and summarization of the overall value of these therapies is therefore important. It is important for clinicians to recognize the magnitude of benefit of each intervention considered to be added to the background treatment.…”

Section: Introductionmentioning

confidence: 99%

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Impact of Implantable Defibrillators and Resynchronization Therapy on Outcome in Patients with Left Ventricular Dysfunction – A Meta-Analysis

Abdulla

Haarbo²,

Køber³

et al. 2006

Cardiology

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Background: The clinical benefits of cardiac resynchronization therapy (CRT) and primary prophylactic implantable cardioverter defibrillator (ICD) in patients with left ventricular systolic dysfunction (LVSD) are debated. Objective: To evaluate by a meta-analysis the effect of CRT and prophylactic ICD therapy in patients with LVSD. Methods: Eligible trials evaluating the effect of CRT vs. no-CRT, ICD vs. no-ICD and adding ICD to CRT vs. no-ICD were selected and meta-analyzed. The outcomes were: all cause mortality, cardiac mortality, hospitalization for heart failure and change in exercise tolerance and New York Heart Association class. Results: Implantation of CRT reduced all cause mortality odds ratio (OR) = 0.73 (0.60–0.89) p = 0.002 and hospitalization for heart failure OR = 0.60 (0.45, 0.80) p = 0.001, increased peak oxygen consumption by 1.77 (0.32–3.22) ml/kg/min p = 0.017 and improved New York Heart Association class by at least one class with OR = 1.52 (1.30, 1.77) p < 0.0001. Implantation of ICD reduced all-cause mortality OR = 0.75 (0.59–0.96) p = 0.025 and cardiac mortality OR = 0.63 (0.48, 0.82) p = 0.001. Adding ICD to CRT reduced all cause mortality OR = 0.69 (0.53–0.91) p = 0.008. Conclusion: Selective patients with LVSD benefit from CRT, ICD or both. Further investigations are necessary to clarify which patients benefit most from a single or combined device implantation.

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“…Ermis et al prospectively followed 18 patients undergoing an upgrade of a defibrillator to a CRT-defibrillator, for arrhythmic events. 8 Prior to an upgrade to CRT-defibrillator, 72% of the patients experienced an arrhythmic outcome as opposed to only 11% following the upgrade, suggesting a role of CRT in ameliorating ventricular arrhythmias in patients with HF. In another study, 107 patient with CRT-defibrillator were prospectively followed for arrhythmic events after elective generator change.…”

Section: See Related Article Pp 1282-1288mentioning

confidence: 97%

Myocardial substrate after cardiac resynchronization therapy and the risk of ventricular arrhythmias

Malhotra

2017

Journal of Nuclear Cardiology

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Biventricular Implantable Cardioverter Defibrillators Improve Survival Compared with Biventricular Pacing Alone in Patients with Severe Left Ventricular Dysfunction

Cited by 17 publications

References 28 publications

Clinical Management and Prevention of Sudden Cardiac Death

Clinical Management and Prevention of Sudden Cardiac Death

Impact of Implantable Defibrillators and Resynchronization Therapy on Outcome in Patients with Left Ventricular Dysfunction – A Meta-Analysis

Myocardial substrate after cardiac resynchronization therapy and the risk of ventricular arrhythmias

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