Biventricular Repair in a Neonate With Obstructive Inflow Cardiac Rhabdomyoma and Tuberous Sclerosis

Hood, Hunter W.; Dodge‐Khatami, Ali; Parnell, Aimee S.; Salazar, Jorge D.

doi:10.1177/2150135114561689

Cited by 4 publications

(1 citation statement)

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“…It is theorized that estrogens from the mother, transmitted transplacentally to the fetus, contribute to cardiac rhabdomyoma growth during intrauterine development 21 . Consequently, rhabdomyoma cells lose their division capacity postnatally, with over 80% of tumors expected to regress completely in early infancy 22 . Our findings indicate that two of the three cases where prenatal heart mass was detected showed spontaneous regression during clinical follow-up.…”

Section: Discussionmentioning

confidence: 99%

Neonatal Cardiac Rhabdomyoma: A Single-Center Experience

Kaya,

Akduman,

Dilli

et al. 2024

Z Geburtshilfe Neonatol

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Aim Cardiac rhabdomyoma, known as the most common benign cardiac tumor in childhood, is strongly associated with tuberous sclerosis complex. This study aims to present our single-center experience regarding clinical observations, diagnostic approaches, and treatment modalities for cardiac rhabdomyoma identified during the neonatal period. Patients and Methods In this clinical observational study, we retrospectively assessed the outcomes of 12 newborn patients diagnosed with cardiac rhabdomyoma who were followed up in our neonatal intensive care unit over the past 12 years. Results The mean gestational age of the patients was 38.2±1.6 weeks, with an average birth weight of 3193±314 grams. The mean postnatal age at initial diagnosis was 12.42±15.75 days. Tuberous sclerosis complex was clinically identified in 50% of cases (six patients). Seven infants received everolimus treatment, while three infants underwent clinical monitoring without specific interventions. A significant reduction in cardiac mass size was observed in all surviving patients, leading to their subsequent discharge from the hospital. Conclusion Cardiac rhabdomyomas often undergo spontaneous regression in early childhood. However, in cases with obstructive lesions or arrhythmias, they may present life-threatening consequences. Timely diagnosis, appropriate clinical management, and monitoring are crucial in optimizing outcomes for neonates with cardiac rhabdomyoma.

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Section: Discussionmentioning

confidence: 99%