Bivirkninger ved bruk av antikoagulasjonsmidler i 2013–15

Eek, Anne Katrine; Strøm, Bjorn Oddvar; Bakkehøi, Gine; Stenberg-Nilsen, Hanne

doi:10.4045/tidsskr.17.0706

Cited by 7 publications

(5 citation statements)

References 3 publications

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“…[2][3][4][5] In Norway, DOACs have gained popularity and, of anticoagulant users in 2018, 27% used warfarin and 73% used DOAC. 6 During the DOAC era, cardiac surgeons have recognised that these drugs are potent anticoagulants, and a need for up to 10 days withdrawal prior to cardiac surgery has been suggested. 7 To evaluate our clinical experience of bleeding-related complications in DOAC users, we explored and analysed data from the register of cardiac surgery at the Department of Cardiothoracic Surgery.…”

Section: Introductionmentioning

confidence: 99%

Operative survival in patients with acute aortic disease in the era of newer oral anticoagulants

Bjørnstad¹,

Khan

Røed-Undlien

et al. 2020

Open Heart

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AimsThe aim of this study was the analysis of the risk associated with direct oral anticoagulants (DOACs) in patients undergoing non-elective operations on the proximal aorta due to aortic disease.Methods and resultsData from the department’s register of cardiac surgery was analysed retrospectively with emphasis on operative mortality. 135 non-elective operations for proximal aortic disease (October 2016 to 2018) were identified, of which 19 died during the first 90 days. DOAC use was the top-ranked risk factor in the univariate analysis with a HR of 9.6 (3.1 to 29), p=0.00007. Using a Cox proportional hazards model including the most relevant risk factors, the risk associated with DOAC use remained significant with a HR of 6.1 (1.4 to 26.3), p=0.015. We did not find increased risk associated with warfarin use.ConclusionIn patients undergoing non-elective operations on the proximal aorta due to aortic disease, the use of DOAC is associated with increased operative mortality.

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Section: Introductionmentioning

confidence: 99%

Operative survival in patients with acute aortic disease in the era of newer oral anticoagulants

Bjørnstad¹,

Khan

Røed-Undlien

et al. 2020

Open Heart

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“…Of the selected studies, one was conducted in the Netherlands with the inclusion of data from Norway [33] and the remainder were undertaken in Norway [34,35,36,37,38]. Three articles [34,36,37] were in the Norwegian language and the rest [33,35,38] were published in English. They all used a cross-sectional descriptive design for data collection and analysis.…”

Section: Resultsmentioning

confidence: 99%

“…They all used a cross-sectional descriptive design for data collection and analysis. The findings of the selected studies on ADR reporting and handling in the Norwegian healthcare context were presented under three central aspects of ‘patient reporting schema’ [33,36], ‘healthcare provider reporting schema’ [33,34,36,37], and ‘current pharmacovigilance system’ [33,35,36,37,38]. The characteristics of the studies’ findings were summarized in Table 3.…”

Section: Resultsmentioning

confidence: 99%

“…The highest number of fatal outcomes were related to rivaroxaban (1.1 deaths/1000 users). Comorbidities, older age, and polypharmacy contributed to increased seriousness of side effects and patient death [37].…”

Section: Resultsmentioning

confidence: 99%

“…It was impossible to share patients’ reports with the primary healthcare provider [33]. The spontaneous reporting system by healthcare providers could not be used to compare the incidence of ADRs associated with different medicines within the same class [37]. ADR reports from patients were more varied than those from healthcare providers.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Adverse Drug Reactions in Norway: A Systematic Review

et al. 2019

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Prescription medicines aim to relieve patients’ suffering but they can be associated with adverse side effects or adverse drug reactions (ADRs). ADRs are an important cause of hospital admissions and a financial burden on healthcare systems across the globe. There is little integrative and collective knowledge on ADR reporting and monitoring in the Norwegian healthcare system. Accordingly, this systematic review aims to investigate the current trends in ADR reporting, monitoring, and handling in the Norwegian healthcare system and describe related interventions. Appropriate keywords, with regard to ADRs in both English and Norwegian languages, were used to retrieve articles published from 2010 to 2019. Six articles met the inclusion criteria. The findings offer a comprehensive picture of ADR reporting and monitoring in the Norwegian healthcare system. Psychotropic medicines were most commonly implicated by patients, while professionals most commonly reported ADRs associated with anticoagulants. The current ADR systems were compiled with the involvement of both patients and healthcare providers to record all types of drugs and ADRs of various severities, and aimed at improving ADR tracking. However, there is a need to improve current initiatives in terms of feedback and quality, and more studies are needed to explore how ADR profiles, and the associated vigilance, can improve the safety of medicines management in Norway.

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Risks of oral anticoagulants: Analysis of adverse drug reactions reported to the Portuguese National Pharmacovigilance System

Martins,

Monteiro,

Duarte

2024

Pharmacology Res & Perspec

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Cardiovascular diseases are the leading cause of death globally, making the use of oral anticoagulants for prevention increasingly important. Historically, warfarin has played a significant role in this context. In recent years, introduction of new oral anticoagulants, such as rivaroxaban, apixaban, dabigatran, and edoxaban, has been seen. This study evaluates the risk associated with the use of oral anticoagulants by analyzing spontaneous adverse drug reactions reported to the Portuguese Pharmacovigilance System from 2012 to 2021. The study includes 951 adverse drug reactions reports, with the majority (n = 770; 80.97%) classified as serious. Of the 770 serious adverse drug reactions reports, the most commonly reported seriousness criterion was “Clinically Important” (n = 350; 45.45%). In terms of demographics, there was a higher reporting rate among the elderly population, with a greater prevalence of females. The System Organ Class group with the highest number of adverse drug reactions was “Gastrointestinal disorders,” with the most commonly reported Preferred Term being “Gastrointestinal hemorrhage,” and dabigatran was the most frequently reported drug. In summary, oral anticoagulants have adverse drug reactions that require continuous monitoring. Accurate identification and monitorization of adverse drug reactions is an important starting point to improve drug safety in population.

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Bivirkninger ved bruk av antikoagulasjonsmidler i 2013–15

Cited by 7 publications

References 3 publications

Operative survival in patients with acute aortic disease in the era of newer oral anticoagulants

Operative survival in patients with acute aortic disease in the era of newer oral anticoagulants

Adverse Drug Reactions in Norway: A Systematic Review

Risks of oral anticoagulants: Analysis of adverse drug reactions reported to the Portuguese National Pharmacovigilance System

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