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Mayr, B.; Wilhelm, Bettina; Reifinger, M.; Brem, Gottfried

doi:10.1023/a:1006412623142

Cited by 6 publications

(1 citation statement)

References 31 publications

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“…Examples are the Macrophage Stimulating 1 Receptor ( MST1R , RON , or STK ) [ 48 ], the TWIST1 oncogene [ 49 ], the mRNA of estrogen receptor gene ( ER ) [ 50 ], or CyclinA [ 51 ] ( Table 1 ). Some other human breast cancer key genes were also analyzed in feline mammary carcinomas at the sequence level (e.g., the tumor suppressor and cell cycle regulatory genes p21 WAF1 and p27 Kip1 by Mayr et al in 2000 [ 52 ] or the oncogene RAS , specifically N- , Ki- , and Ha-ras performed by Watzinger et al [ 53 ]), but the search for any mutational signal in the latter referred genes failed. Although these results are apparently negative [ 53 ] from the classical gene activation point of view, the fact that they do not present an identifiable mutation (either copy number variations or point mutations) do not imply that they do not play a role in the pathogenesis or progression of feline mammary tumors.…”

Section: Cat Critical Cancer Genes: a Sequence Perspectivementioning

confidence: 99%

Cat Mammary Tumors: Genetic Models for the Human Counterpart

Adega

Borges

Chaves

2016

Veterinary Sciences

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The records are not clear, but Man has been sheltering the cat inside his home for over 12,000 years. The close proximity of this companion animal, however, goes beyond sharing the same roof; it extends to the great similarity found at the cellular and molecular levels. Researchers have found a striking resemblance between subtypes of feline mammary tumors and their human counterparts that goes from the genes to the pathways involved in cancer initiation and progression. Spontaneous cat mammary pre-invasive intraepithelial lesions (hyperplasias and neoplasias) and malignant lesions seem to share a wide repertoire of molecular features with their human counterparts. In the present review, we tried to compile all the genetics aspects published (i.e., chromosomal alterations, critical cancer genes and their expression) regarding cat mammary tumors, which support the cat as a valuable alternative in vitro cell and animal model (i.e., cat mammary cell lines and the spontaneous tumors, respectively), but also to present a critical point of view of some of the issues that really need to be investigated in future research.

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