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Seredenin, S. B.; Gudasheva, T. A.; Boiko, S. S.; Ковалев, Г. И.; Voronin, M. V.; Yarkova, M. A.

doi:10.1023/a:1016293904149

Cited by 23 publications

(6 citation statements)

References 2 publications

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“…In vitro studies showed that dipeptides thymogen, Vilon, and Bestim in low concentrations exhibit immunomodulatory activity [1,6,7,12]. Short peptides are considered as possible universal regulators of vital functions in the organism [1,9,12].…”

Section: Resultsmentioning

confidence: 99%

Effect of carnosine on immunocompetent cells from alcoholic patients

et al. 2004

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We studied the effect of natural dipeptide carnosine on phagocytosis, respiratory burst in neutrophils, and subpopulation composition of lymphocytes from healthy donors and alcoholic patients. Carnosine in vitro produced different effects on immunocompetent cells from healthy donors and patients with alcoholism. In patients with alcoholism phagocytic activity of leukocytes and generation of reaction oxygen species increased under the influence of carnosine in a concentration of 0.01 mM, but decreased after treatment with this compound in a concentration of 1 mM. Carnosine in both concentrations stimulated the respiratory burst, but had no effect on the count of phagocytic cells in healthy donors. Carnosine in a concentration of 0.01 mM increased the number of lymphocytes carrying apoptosis markers (CD95+) in patients with alcoholism not receiving therapy. Our results indicate that carnosine holds much promise for the therapy of alcoholism.

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Section: Resultsmentioning

confidence: 99%

Effect of carnosine on immunocompetent cells from alcoholic patients

et al. 2004

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“…CPG content was found to depend on the type of emotional stress reaction of the animals. CPG content in the whole brain of stress-resistant С57Bl/6 mice was 1.5 times higher than in non-stress-resistant Вalb/c mice [8]. This suggests that CPG plays a role of endogenous anxiolytic agent.…”

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confidence: 86%

“…In addition, CPG possessed in vitro anticoagulant and fi brinolytic properties in concentrations of 10 -5 -10 -10 М and modulates membrane potential in synaptoneurosomes in concentration 10 -6 М [5,7]. In experiments on rats, CPG exhibits anxiolytic activity in elevated plus maze test in doses of 0.05-0.10 mg/kg intraperitoneally [3] and in open fi eld test in doses of 0.01-0.10 mg/kg [8]. Anxiolytic effect of CPG is selective.…”

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confidence: 99%

Regional and Subcellular Localization of Cycloprolylglycine in Rat Brain

et al. 2010

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HPLC analysis showed that endogenous cyclopeptide cycloprolylglycine exhibiting mnemotropic and anxiolytic properties is nonuniformly distributed between brain structures in rats: its contents in the whole brain, cortex, and hippocampus were 29.2±1.6, 38.9±8.0, 126.4±32.4 nmol/g, respectively. Cycloprolylglycine distribution between subcellular fractions of brain neurons is also nonuniform: 60% cyclopeptide appeared in the nuclear fraction.

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“…The in vivo investigations of cyclo (Pro—Gly) showed that this dipeptide has pharmacological profile resemble that of Piracetam. Like Piracetam, cyclo (Pro—Gly) possess nootropic [22], neuroprotective, antihypoxic [23] and anxiolytic [24] activities. Evaluation of the effect on memory phases in passive avoidance test in rats demonstrated that cyclo (Pro—Gly) similar to Piracetam is active only when administered before learning.…”

Section: Noopept a Dipeptide Nootropic Drugmentioning

confidence: 99%

Novel Technologies for Dipeptide Drugs Design and their Implantation

Gudasheva

Ostrovskaya

Середенин

2018

CPD

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The article is an overview of author’s data obtained in the framework of the project “The Creation of dipeptide preparations” at the V.V. Zakusov Institute of Pharmacology, Moscow, Russia. Advantages of dipeptides over longer peptides consist in that they are orally active owing to higher sta-bility and ability to penetrate biological barriers due to the presence of specific ATP–dependent trans-porters in enterocytes and blood-brain barrier. Two original approaches for dipeptide drugs design have been developed. Both of them are based on the idea of a leading role of central dipeptide fragment of the peptide chain beta-turn in the peptide-receptor interaction. The first approach, named “peptide drug-based design” represents the transformation of known nonpeptide drug into its dipeptide topological analog. The latter usually corresponds to a beta-turn of some regulatory peptide. The second approach represents the design of tripeptoide mimetic of the beta-turn of regulatory peptide or protein. The results of the studies, which led to the discovery of endogenous prototypes of the known non-peptide drugs piracetam and sulpiride, are presented herein. The paper discusses the process, based on the above-mentioned principles, that was used in designing of nontoxic, orally available, highly effective dipeptide drugs: nootropic noopept, dipeptide analog of piracetam; antipsychotic dilept, neurotensin tripeptoid analog; selective anxiolytic GB-115, tripeptoid analog of CCK-4, and potential neuroprotector GK-2, homodimeric dipeptide analog of NGF.

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Cited by 23 publications

References 2 publications

Effect of carnosine on immunocompetent cells from alcoholic patients

Effect of carnosine on immunocompetent cells from alcoholic patients

Regional and Subcellular Localization of Cycloprolylglycine in Rat Brain

Novel Technologies for Dipeptide Drugs Design and their Implantation

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