Black bean husk and black rice anthocyanin extracts modulated gut microbiota and serum metabolites for improvement in type 2 diabetic rats

Sun, Mubai; Li, Da; Mao, Hua; Miao, Xinyu; Su, Ying; Chi, Yanping; Li, Yueqiao; Sun, Ruiyue; Niu, Honghong; Wang, Jinghui

doi:10.1039/d2fo01165d

Cited by 23 publications

(10 citation statements)

References 62 publications

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“…Sure enough, a significant decrease in the content of SCFAs was observed in the psicose group, especially the propionate and butyrate, which were strongly responsible for Muc-2 secretion. Consistent with previous findings [45,46], Akkermansia and Lactobacillus were positively associated with the expression of Muc-2 coupled with the levels of propionate and butyrate, and significantly negatively associated with inflammatory cytokines.…”

Section: Discussionsupporting

confidence: 92%

D-Psicose intake exacerbates dextran sulfate sodium-induced colitis in mice through alteration in the gut microbiota and dysfunction of mucosal barrier

Zhang¹,

Li²,

Wang³

et al. 2024

Food Science and Human Wellness

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D-Psicose, as a low-calorie rare sugar, has attracted a lot of attention in recent years for alternating to sucrose. The anti-obesity effect of D-psicose has been extensively confirmed in previous studies, however, the impact of D-psicose on colitis remains vague. Here, we firstly evaluated the effect of the D-psicose prophylactic intervention on dextran sulfate sodium-induced colitis in C57BL/6 mice. The pathological symptoms, inflammatory cytokines levels, gut microbiota composition, short chain fatty acids (SCFAs) production and colonic barrier integrity were comprehensively evaluated. The results confirmed that D-psicose intervention aggravated colitis, characterized by the exacerbation of colon shortening, increase of colonic inflammatory infiltration, and marked exaltation of disease activity indices and IL-6, IL-1β and TNF-α levels. Further, the dysfunction of gut microbiota was identified in the psicose group. The abundance of pro-inflammatory bacteria Lachnospiraceae_NK4A136_group was significantly up-regulated while the abundance of probiotics Akkermansia and Lactobacillus were significantly down-regulated in the psicose group compared to the model group. Moreover, the production of SCFAs was suppressed in the psicose group, accompanied by a decrease in the level of mucin 2 (Muc-2). Collectively, the underlying mechanism of the exacerbation of colitis by D-psicose intervention might be attributed to microbiota dysfunction accompanied by the reduction of SCFAs, which leads to the damage of the mucosal barrier and the intensification of inflammatory invasion.

show abstract

Section: Discussionsupporting

confidence: 92%

D-Psicose intake exacerbates dextran sulfate sodium-induced colitis in mice through alteration in the gut microbiota and dysfunction of mucosal barrier

Zhang¹,

Li²,

Wang³

et al. 2024

Food Science and Human Wellness

View full text Add to dashboard Cite

show abstract

“…Sure enough, a significant decrease in the content of SCFAs was observed in the Psicose group, especially the propionate and butyrate, which were strongly responsible for Muc-2 secretion. Consistent with previous findings 42,43 , Akkermansia and Lactobacillus were positively associated with the expression of Muc-2 coupled with the levels of propionate and butyrate, and significantly negatively associated with inflammatory cytokines.…”

Section: Spearman Correlation Analysissupporting

confidence: 92%

D-Psicose intake exacerbates DSS-induced colitis in mice through alteration in the gut microbiota and dysfunction of mucosal barrier

Wang

Zhang

et al. 2022

Preprint

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D-Psicose, as a low-calorie rare sugar, has attracted a lot of attention in recent years for alternating to sucrose. The anti-obesity effect of D-Psicose has been extensively confirmed in previous studies, however, the impact of D-Psicose on colitis remains vague. Here, we firstly evaluated the effect of 21 days of D-Psicose prophylactic intervention on DSS-induced colitis in C57BL/6 mice. The pathological symptoms, inflammatory cytokines levels, gut microbiota composition, short chain fatty acids production and colonic barrier integrity were comprehensively evaluated. The results confirmed that D-Psicose intervention aggravated colitis, characterized by the exacerbation of colon shortening, increase of colonic inflammatory infiltration, and marked exaltation of disease activity indices and IL-6, IL-1β and TNF-α levels. Further, the dysfunction of gut microbiota was identified in the Psicose group. The abundance of pro-inflammatory bacteria Lachnospiraceae_NK4A136_group was significantly up-regulated while the abundance of probiotics Akkermansia and Lactobacillus were significantly down-regulated in the Psicose group compared to the Model group. Moreover, the production of short chain fatty acids was suppressed in the Psicose group, accompanied by a decrease in the level of Muc-2. Collectively, the underlying mechanism of the exacerbation of colitis by D-Psicose intervention might be attributed to microbiota dysfunction accompanied by the reduction of short chain fatty acids, which leads to the damage of the mucosal barrier and the intensification of inflammatory invasion.

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“…Vitisin A could effectively down-regulate HMGCR and up-regulate LDLR expression, especially in the high-dose group. Some in vivo studies revealed that blueberry anthocyanins, black bean husk and black rice anthocyanin extracts were also able to down-regulate the gene expression of hepatic HMGCR, thereby inhibiting the synthesis of cholesterol in the liver [ 41 , 42 , 43 ]. An anthocyanin-rich fraction has been proven to markedly enhance LDL cholesterol uptake by increasing the LDLR protein level [ 12 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

Cholesterol-Lowering Activity of Vitisin A Is Mediated by Inhibiting Cholesterol Biosynthesis and Enhancing LDL Uptake in HepG2 Cells

Yuan

Zhu

et al. 2023

IJMS

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Pyranoanthocyanins have been reported to possess better chemical stability and bioactivities than monomeric anthocyanins in some aspects. The hypocholesterolemic activity of pyranoanthocyanins is unclear. In view of this, this study was conducted to compare the cholesterol-lowering activities of Vitisin A with the anthocyanin counterpart Cyanidin-3-O-glucoside(C3G) in HepG2 cells and to investigate the interaction of Vitisin A with the expression of genes and proteins associated with cholesterol metabolism. HepG2 cells were incubated with 40 μM cholesterol and 4 μM 25-hydroxycholeterol with various concentrations of Vitisin A or C3G for 24 h. It was found that Vitisin A decreased the cholesterol levels at the concentrations of 100 μM and 200 μM with a dose–response relationship, while C3G exhibited no significant effect on cellular cholesterol. Furthermore, Vitisin A could down-regulate 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMGCR) to inhibit cholesterol biosynthesis through a sterol regulatory element-binding protein 2 (SREBP2)-dependent mechanism, and up-regulate low-density lipoprotein receptor (LDLR) and blunt the secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9) protein to promote intracellular LDL uptake without LDLR degradation. In conclusion, Vitisin A demonstrated hypocholesterolemic activity, by inhibiting cholesterol biosynthesis and enhancing LDL uptake in HepG2 cells.

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Black bean husk and black rice anthocyanin extracts modulated gut microbiota and serum metabolites for improvement in type 2 diabetic rats

Abstract: Black rice and black bean have not yet been fully investigated as healthy foods for their therapeutic effects on type 2 diabetes mellitus (T2DM). In this study, we aimed to...

Cited by 23 publications

References 62 publications

D-Psicose intake exacerbates dextran sulfate sodium-induced colitis in mice through alteration in the gut microbiota and dysfunction of mucosal barrier

D-Psicose intake exacerbates dextran sulfate sodium-induced colitis in mice through alteration in the gut microbiota and dysfunction of mucosal barrier

D-Psicose intake exacerbates DSS-induced colitis in mice through alteration in the gut microbiota and dysfunction of mucosal barrier

Cholesterol-Lowering Activity of Vitisin A Is Mediated by Inhibiting Cholesterol Biosynthesis and Enhancing LDL Uptake in HepG2 Cells

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