Black carp RIPK1 negatively regulates MAVS-mediated antiviral signaling during the innate immune activation

Xie, Xinchi; Cao, Yingyi; Dai, Yuhan; Chen, Zhaoyuan; Wei, Jing; Tan, Yaqi; Wu, Hui; Feng, Hao

doi:10.1016/j.dci.2020.103726

Cited by 14 publications

(7 citation statements)

References 36 publications

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“…For example, RIPK3 and RIPK1 mutant mouse models (RIPK3 D/D and RIPK1 D/D ) were constructed, and embryonic death and necroptosis during embryonic development and inflammation after birth were prevented (Rickard et al 2014). As described in the previous sections, some key genes, metabolites and signalling networks relevant to LRCD in aquatic fish are similar to those of vertebrates (Babin & Vernier 1989;Masumoto et al 2003;Wang & Huang 2007;Sakamaki & Satou 2009;Holtta-Vuori et al 2010;Yang et al 2013;Ding et al 2015;Li et al 2017b;Xie et al 2020;Sun et al 2020a). Thus, therapeutic strategies in vertebrates can be used for references in the prevention and treatment of fish-related diseases.…”

Section: Discussionmentioning

confidence: 99%

“…2015; Xie et al . 2020; Zhang et al . 2020b), and notably, viruses respond very differently in different cells.…”

Section: Discussionmentioning

confidence: 99%

“…LRCD induced by fish viruses is a new research field that has emerged in recent years, and related research progress is thus still scarce. Only a few virus strains have been preliminarily studied (Zhou et al 2015;Xie et al 2020;, and notably, viruses respond very differently in different cells. The occurrence of intracellular death and the different mechanisms of the same fish virus strain in different host cells have not been investigated, and more reports from this field are needed because they may provide a theoretical basis for clarifying the pathogenic mechanism of these viruses for developing corresponding prevention and control technologies.…”

Section: Discussionmentioning

confidence: 99%

“…Overexpression of bcRIPK1 in epithelioma papulosum cyprini (EPC) cells inhibited the IFN inducibility of bcMAVS and inhibited the antiviral capacity of bcMAVS against SVCV and GCRV (Xie et al . 2020). In mycobacteria‐infected zebrafish models, macrophage necroptosis leads to cell lysis and then releases the pathogen into the extracellular environment, which is a key step in the pathogenesis of tuberculosis (Roca & Ramakrishnan 2013).…”

Section: Necroptosismentioning

confidence: 99%

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Lytic regulated cell death in aquaculture fish

Xia

Zhang

et al. 2021

Reviews in Aquaculture

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Cell death is an important physiological and pathological phenomenon in multicellular animals and occurs widely in various body's systems. In recent years, researchers have gained a deeper understanding of the mechanisms of necrosis and apoptosis in mammals. In addition, many new forms of lytic regulated cell death (RCD), such as pyroptosis, necroptosis and ferroptosis, have been discovered, thus enhancing our understanding of the molecular mechanisms of programmed cell death (PCD) and the associated signalling pathways as well as their relationship with diseases. However, our understanding of lytic RCD in fish is limited. Recently, some progress has been made regarding the induction conditions, expression of related genes and regulation of lytic RCD in fish. Furthermore, research on the roles of lytic RCD in tissue development, against pathogenic microorganism, inflammatory disease and neurological disease, has also been advanced. Understanding lytic RCD in fish will enable the regulation of its occurrence through human intervention to inhibit disease processes, improve fish health and explore possible countermeasures based on these basic theoretical studies.

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Section: Discussionmentioning

confidence: 99%

“…2015; Xie et al . 2020; Zhang et al . 2020b), and notably, viruses respond very differently in different cells.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Necroptosismentioning

confidence: 99%

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Lytic regulated cell death in aquaculture fish

Xia

Zhang

et al. 2021

Reviews in Aquaculture

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“…Are the paralogues shown in the Ensembl database incorrect? Although RIPK1–3 have been adequately reported in human and mice and characterized with similar functions in pig, chicken, frog, zebrafish, black carp and lamprey, they remain poorly investigated in other vertebrate species ( Ishizawa et al, 2006 ; Chang et al, 2010 ; Park et al, 2018 ; Hou et al, 2020 ; Xie et al, 2020 ; Liu et al, 2021 ). Meanwhile, little is known about RIPK4–7 roles in immune responses.…”

Section: Introductionmentioning

confidence: 99%

Comparative and evolutionary analysis of RIP kinases in immune responses

Jiang²,

Li³

et al. 2022

Front. Genet.

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The group of receptor-interacting protein (RIP) kinases has seven members (RIPK1–7), with one homologous kinase domain but distinct non-kinase regions. Although RIPK1–3 have emerged as key modulators of inflammation and cell death, few studies have connected RIPK4–7 to immune responses. The divergence in domain structures and paralogue information in the Ensembl database have raised question about the phylogeny of RIPK1–7. In this study, phylogenetic trees of RIPK1–7 and paralogues constructed using full-length amino acid sequences or Kinase domain demonstrate that RIPK6 and RIPK7 are distinct from RIPK1–5 and paralogues shown in the Ensembl database are inaccurate. Comparative and evolutionary analyses were subsequently performed to gain new clues about the potential functions of RIPK3–7. RIPK3 gene loss in birds and animals that undergo torpor, a common physiological phenomenon in cold environments, implies that RIPK3 may be involved in ischemia-reperfusion injury and/or high metabolic rate. The negligible expression of RIPK4 and RIPK5 in immune cells is likely responsible for the lack of studies on the direct role of these members in immunity; RIPK6 and RIPK7 are conserved among plants, invertebrates and vertebrates, and dominantly expressed in innate immune cells, indicating their roles in innate immunity. Overall, our results provide insights into the multifaceted and conserved biochemical functions of RIP kinases.

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The negative regulation of retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) signaling pathway in fish

Chang

2021

Developmental & Comparative Immunology

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Black carp RIPK1 negatively regulates MAVS-mediated antiviral signaling during the innate immune activation

Cited by 14 publications

References 36 publications

Lytic regulated cell death in aquaculture fish

Lytic regulated cell death in aquaculture fish

Comparative and evolutionary analysis of RIP kinases in immune responses

The negative regulation of retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) signaling pathway in fish

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