This study was conducted to evaluate the effect of liming (CaCO3 1000 kg ha−1) and application of organic fertilizers (rotted farmyard manure 40 t ha−1) and six different combination of mineral fertilizers: NPK 15:15:15 800 kg ha−1 + KAN (calcium ammonium nitrate) 240 kg ha−1; NPK 15:15:15 400 kg ha−1 + MCB (water-soluble mineral fertilizer NPK 13:11:20 + 2MgO + microelements + humic acid) 300 kg ha−1 + KAN 125 kg ha−1; MCB 400 kg ha−1; MCB 400 kg ha−1 + KMg (water-soluble mineral fertilizer Multi KMg 13:0:43 + 2MgO) 100 kg ha−1; MCB 600 kg ha−1 + KMg 100 kg ha−1 and MCB 800 kg ha−1 + KMg 100 kg ha−1 on yield and other productivity parameters of potato (Kennebec variety). The aim of the research was to optimize the system of potato plant nutrition for maximum profitability in the future potato production on acid soils of mountainous region of Montenegro. The experiments were carried out during 2015 and 2016, on Dystric Cambisols. The results obtained suggested that in both years, the highest values for all studied parameters were measured on plots with combined application of liming, organic and mineral fertilizers. In addition, a significant influence on the increase in the number of tubers per plant, the average tuber weight and the total yield was also demonstrated in all individual trials of potato nutrition, and the interaction of organic manure and mineral fertilizer. Fertilizing with rotted farmyard manure had significantly increased potato productivity, with the effect more pronounced in treatments with liming. The highest number of tubers (6.2 and 7.2), average tuber weight (93.5 g and 101.0 g) and yield (27.6 t ha−1 in 2015 and 34.8 t ha−1 in 2016, respectively) were obtained using combinations of MCB 800 kg ha−1 + KMg 100 kg ha−1 on variants fertilized with rotted farmyard manure and liming. This research is a valuable source of information for potato growers and scientists from this region as the results have shown how fertilization is raising productivity in this environment and its importance in the future potato growing on acid soils in mountainous regions of Montenegro and Western Balkans.