Black phosphorus quantum dots induce myocardial inflammatory responses and metabolic disorders in mice

Shen, Chao; Ding, Xiaoyan; Ruan, Jinpeng; Ruan, Fengkai; Hu, Weiping; Huang, Jian; He, Chengyong; Yu, Yi; Zuo, Zhenghong

doi:10.1016/j.jes.2023.01.004

Cited by 6 publications

(4 citation statements)

References 67 publications

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“…In terms of glucose and lipid metabolism, certain nanomaterials have been investigated as PPAR-𝛾 agonists. Chao Shen et al [41] demonstrated that BP increased PPAR-𝛾 gene expression and affected glucose/lipid metabolism in the heart of mice. Long Yuan et al [42] found that gold nanocubes upregulated PPAR-𝛾 expression at both mRNA and protein levels in mesenchymal stem cells.…”

Section: Discussionmentioning

confidence: 99%

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Black Phosphorus as a Targeting PPAR‐γ Agonist to Reverse Chemoresistance in Patient‐derived Organoids, Mice, and Pancreatic Tumor Cells

Jiang

Liu

Shi

et al. 2023

Adv Healthcare Materials

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Black phosphorus (BP) exhibits significant potential for clinical applications. However, further research is necessary to uncover the unknown biological functions of BP and broaden its applications across various fields. This study investigates the potential of BP as a targeting PPAR‐γ agonist to overcome chemoresistance in the treatment of pancreatic adenocarcinoma (PAAD) using 2D and 3D cell lines, patient‐derived organoids (PDOs), and mouse models. RNA‐sequencing analysis shows that BP treatment enriches differentially expressed genes in the PPAR pathway, and molecular modeling predicts the potential docking site between BP and PPAR‐γ. Transcriptional activity assays are further to verify the activation of PPAR‐γ. BP‐activated PPAR‐γ inhibits cancer stem cell (CSC) properties and expression of biomarkers such as CD44 and c‐Myc, which are involved in chemoresistance. Notably, CD44 overexpression in tumor cells renders them susceptible to BP while insensitive to gemcitabine. This indicates that BP preferentially targets stem‐like cells, which exhibit heightened resistance to chemotherapeutic drugs. A combination treatment strategy involving BP and gemcitabine is developed, demonstrating enhanced treatment efficacy of PAAD in both in vitro and in vivo models. Thus, BP serves as a PPAR‐γ agonist capable of reversing chemoresistance, establishing it as a potent anti‐tumor approach for the treatment of PAAD.

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Section: Discussionmentioning

confidence: 99%

“…Chao Shen et al. [ 41 ] demonstrated that BP increased PPAR‐γ gene expression and affected glucose/lipid metabolism in the heart of mice. Long Yuan et al.…”

Section: Discussionmentioning

confidence: 99%

Black Phosphorus as a Targeting PPAR‐γ Agonist to Reverse Chemoresistance in Patient‐derived Organoids, Mice, and Pancreatic Tumor Cells

Jiang

Liu

Shi

et al. 2023

Adv Healthcare Materials

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“…Besides inducing insulin resistance in the kidney, BPDs could also disturb glucose homeostasis and induce insulin resistance in muscles by blocking insulin signaling (PI3K/AKT), thus leading to a metabolic glucose disorder . Moreover, BPDs induced cardiac inflammatory responses in mice after intragastric administration even at a low dose of 0.1 mg kg –1 …”

Section: Cytotoxicity and Biological Responses Induced By Nano-bpsmentioning

confidence: 99%

“…81 Moreover, BPDs induced cardiac inflammatory responses in mice after intragastric administration even at a low dose of 0.1 mg kg −1 . 82 Interestingly, nano-BPs protected neurons from Cu 2+induced oxidative damage by selectively capturing Cu 2+83 or upregulating the expression of antioxidant genes and nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent antioxidant signaling pathways in stem cells, which improved the survival rate after transplantation, making nano-BPs promising candidates for the treatment of neurological disorder. 84…”

Section: Immunological Effectsmentioning

confidence: 99%

Recent Advances in the Biological Responses to Nano-black Phosphorus: Understanding the Importance of Intrinsic Properties and Cell Types

Zhao

Donskyi

Xiong

et al. 2023

Environ. Sci. Technol.

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The production scalability and increasing demand for nanoblack phosphorus materials (nano-BPs) inevitably lead to their environmental leakage, thereby raising the risk of human exposure through inhalation, ingestion, dermal, and even intravenous pathways. Consequently, a systematic evaluation of their potential impacts on human health is necessary. This Review outlines recent progress in the understanding of various biological responses to nano-BPs. Attention is particularly given to the inconsistent toxicological findings caused by a wide variation of nano-BPs' physicochemical properties, toxicological testing methods, and cell types examined in each study. Additionally, cellular uptake and intracellular trafficking, cell death modes, immunological effects, and other biologically relevant processes are discussed in detail, providing evidence for the potential health implications of nano-BPs. Finally, we address the remaining challenges related to the health risk evaluation of nano-BPs and propose a broader range of applications for these promising nanomaterials.

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Advances in Black Phosphorus Quantum Dots for Cancer Research: Synthesis, Characterization, and Applications

Einafshar,

Ghorbani

2024

Top Curr Chem (Z)

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Black phosphorus quantum dots induce myocardial inflammatory responses and metabolic disorders in mice

Cited by 6 publications

References 67 publications

Black Phosphorus as a Targeting PPAR‐γ Agonist to Reverse Chemoresistance in Patient‐derived Organoids, Mice, and Pancreatic Tumor Cells

Black Phosphorus as a Targeting PPAR‐γ Agonist to Reverse Chemoresistance in Patient‐derived Organoids, Mice, and Pancreatic Tumor Cells

Recent Advances in the Biological Responses to Nano-black Phosphorus: Understanding the Importance of Intrinsic Properties and Cell Types

Advances in Black Phosphorus Quantum Dots for Cancer Research: Synthesis, Characterization, and Applications

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