Black porous silicon as a photothermal agent and immunoadjuvant for efficient antitumor immunotherapy

Xu, Wujun; Cui, Pang; Song, Chaojun; Qian, Jing Xia; Feola, Sara; Cerullo, Vincenzo; Li, Fan; Yu, Haijun; Lehto, Vesa‐Pekka

doi:10.1016/j.actbio.2022.08.073

Cited by 14 publications

(8 citation statements)

References 36 publications

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“…However, due to the complexity of the biological barrier, the penetration depth of NPs still needs to be determined by in-depth research. The combination of photodynamic therapy (PDT) and PTT-mediated NPs and checkpoint blocking immunotherapy ( Liu et al, 2019b ; Sun et al, 2021 ; Qiu et al, 2022a ; Xu et al, 2022a ; Yun et al, 2022 ), as well as the combination of NPs and small interacting RNA (siRNA) targeted to checkpoints ( Barshidi et al, 2022 ; Won et al, 2022 ), is expected to effectively activate the immune system, cause tumor degeneration, and get rid of the technical difficulties of tumor penetration.…”

Section: Discussionmentioning

confidence: 99%

Nano-drug delivery system for pancreatic cancer: A visualization and bibliometric analysis

et al. 2022

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Background: Nano drug delivery system (NDDS) can significantly improve the delivery and efficacy of drugs against pancreatic cancer (PC) in many ways. The purpose of this study is to explore the related research fields of NDDS for PC from the perspective of bibliometrics.Methods: Articles and reviews on NDDS for PC published between 2003 and 2022 were obtained from the Web of Science Core Collection. CiteSpace, VOSviewer, R-bibliometrix, and Microsoft Excel were comprehensively used for bibliometric and visual analysis.Results: A total of 1329 papers on NDDS for PC were included. The number of papers showed an upward trend over the past 20 years. The United States contributed the most papers, followed by China, and India. Also, the United States had the highest number of total citations and H-index. The institution with the most papers was Chinese Acad Sci, which was also the most important in international institutional cooperation. Professors Couvreur P and Kazuoka K made great achievements in this field. JOURNAL OF CONTROLLED RELEASE published the most papers and was cited the most. The topics related to the tumor microenvironment such as “tumor microenvironment”, “tumor penetration”, “hypoxia”, “exosome”, and “autophagy”, PC treatment-related topics such as “immunotherapy”, “combination therapy”, “alternating magnetic field/magnetic hyperthermia”, and “ultrasound”, and gene therapy dominated by “siRNA” and “miRNA” were the research hotspots in the field of NDDS for PC.Conclusion: This study systematically uncovered a holistic picture of the performance of NDDS for PC-related literature over the past 20 years. We provided scholars to understand key information in this field with the perspective of bibliometrics, which we believe may greatly facilitate future research in this field.

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Section: Discussionmentioning

confidence: 99%

Nano-drug delivery system for pancreatic cancer: A visualization and bibliometric analysis

et al. 2022

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“…The research results revealed that the mitochondrial ROS level elevation could induce TAMs’ pro-inflammatory polarization, and the therapeutic efficiency could be enhanced after precise delivery. Similarly, Xu et al adopted black porous silicon (BPSi) NPs to act as auxiliary adjuvants to augment immune response, and as photothermal agent to further activate immune response . Accordingly, the enhanced specific antitumor immunity could be achieved.…”

Section: Various Nanomaterials-mediated Tams’ Polarizationsmentioning

confidence: 99%

“…Similarly, Xu et al adopted black porous silicon (BPSi) NPs to act as auxiliary adjuvants to augment immune response, and as photothermal agent to further activate immune response. 85 Accordingly, the enhanced specific antitumor immunity could be achieved. That means mesoporous nanomaterials can be used not only as carriers to deliver regulators for TAMs' reprogramming but also as modulators to activate and/or enhance the regulation effect of TAMs based on their innate properties.…”

Section: Various Nanomaterials-mediated Tams' Polarizationsmentioning

confidence: 99%

Nanomaterials-Involved Tumor-Associated Macrophages’ Reprogramming for Antitumor Therapy

Li,

Hou,

Chu

et al. 2024

ACS Nano

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Tumor-associated macrophages (TAMs) play pivotal roles in tumor development. As primary contents of tumor environment (TME), TAMs secrete inflammation-related substances to regulate tumoral occurrence and development. There are two kinds of TAMs: the tumoricidal M1-like TAMs and protumoral M2-like TAMs. Reprogramming TAMs from immunosuppressive M2 to immunocompetent M1 phenotype is considered a feasible way to improve immunotherapeutic efficiency. Notably, nanomaterials show great potential for biomedical fields due to their controllable structures and properties. There are many types of nanomaterials that exhibit great regulatory activities for TAMs’ reprogramming. In this review, the recent progress of nanomaterials-involved TAMs’ reprogramming is comprehensively discussed. The various nanomaterials for TAMs’ reprogramming and the reprogramming strategies are summarized and introduced. Additionally, the challenges and perspectives of TAMs’ reprogramming for efficient therapy are discussed, aiming to provide inspiration for TAMs’ regulator design and promote the development of TAMs-mediated immunotherapy.

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“…The integration of nanomaterials with photothermal agents or photosensitizers shows promise in enhancing the efficacy of phototherapy while mitigating its adverse effects. Moreover, certain NPs that exhibit robust NIR absorption, such as gold NPs, 116 carbon-based nanomaterials, 117 silicon NPs, 118 and transition metal oxides 119 have emerged as promising photothermal agents for phototherapy. This section provides a comprehensive overview of the utilization of CCM-NPs in phototherapy wherein the integration of cancer cell membranes with these photothermally responsive NPs enables precise and targeted treatment.…”

Section: Ccm-nps In Anti-tumor Therapiesmentioning

confidence: 99%

Cancer cell membrane-coated nanoparticles: a promising anti-tumor bionic platform

Guo,

Wang,

et al. 2024

RSC Adv.

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Black porous silicon as a photothermal agent and immunoadjuvant for efficient antitumor immunotherapy

Cited by 14 publications

References 36 publications

Nano-drug delivery system for pancreatic cancer: A visualization and bibliometric analysis

Nano-drug delivery system for pancreatic cancer: A visualization and bibliometric analysis

Nanomaterials-Involved Tumor-Associated Macrophages’ Reprogramming for Antitumor Therapy

Cancer cell membrane-coated nanoparticles: a promising anti-tumor bionic platform

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