Black Thyroid

Bann, Darrin V.; Goyal, Neerav; Crist, Henry; Goldenberg, David

doi:10.1177/014556131409310-1110

Cited by 9 publications

(7 citation statements)

References 17 publications

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“…In the pathological aspect, decreased pigmentation of malignant cells compared to the surrounding tissue is interestingly common in cases of black thyroid with PTC (9). In our case, the pigmentation was found only in the thyroid parenchyma, but not in the thyroid tumor.…”

Section: Discussionsupporting

confidence: 49%

“…Minocycline-induced black thyroid is often identified as a harmless condition. It is usually asymptomatic and has no role in thyroid dysfunction (9). However, several reports have described accompanying symptoms of neck swelling, thyroiditis, thyroid dysfunction, and benign thyroid neoplasms (9,10,17,18).…”

Section: Discussionmentioning

confidence: 99%

“…The impact of minocycline on the black thyroid has often been reported to be harmless. It occasionally presents with neck swelling, thyroiditis, and benign thyroid neoplasms (9,10). Meanwhile, several studies have reported cases of carcinoma in minocycline-induced black thyroids.…”

Section: Introductionmentioning

confidence: 99%

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Papillary thyroid cancer in black thyroid: a case report and literature review

Kim¹,

Kang²,

Kim³

et al. 2023

Gland Surg

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or black pigments in thyroid follicular cells (3). M i n o c y c l i n e [ 2 -N a p h t h a c e n e c a r b o x a m i d e , 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S-(4alpha,4a alpha,5a alpha,12a alpha))] is a semi-synthetic antibiotic in the tetracycline family and is generally used as a treatment for acne vulgaris (4). It has been reported to cause pigmentation in various tissues, including the skin,

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Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 99%

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Papillary thyroid cancer in black thyroid: a case report and literature review

Kim¹,

Kang²,

Kim³

et al. 2023

Gland Surg

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“…It was discovered in laboratory animals in 1967 and the first human case of black thyroid was described in 1976. Since then, there have been more than 125 cases of black thyroid reported in the literature 3. Clinically, a black thyroid does not affect thyroid function, and only a few cases reported minocycline-induced hyperthyroidism.…”

Section: Discussionmentioning

confidence: 99%

Black thyroid gland and tracheal cartilage

2023

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A woman in her 70s with a history of chronic minocycline use presented with complaints of a non-tender posterior neck mass. A thyroid gland ultrasound showed a highly suspicious right thyroid nodule. A total thyroidectomy revealed darkened discolouration of the thyroid gland and tracheal cartilage. The pathology report showed dark brown granules representing melanin. Chronic minocycline usage is known to cause pigmentation of nails, teeth, bones and the thyroid gland. Our case highlights the importance of recognising that long-term use of minocycline can cause discolouration of the thyroid and tracheal cartilage. Current case studies do not show any adverse health effects associated with black thyroid and tracheal cartilage. For patients who are to undergo neck surgery, physicians need to be aware of this side effect, and that further intervention, such as surgical resection, may not be required.

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“…1 Typically, an incidental surgical finding, black thyroid is thought to be benign and has not been shown to have a causative relationship with cancer. 2 However, the strikingly coal-black appearance of the thyroid may surprise a surgeon, and this image set is a classic example of a black thyroid in association with chronic minocycline therapy.…”

Section: Discussionmentioning

confidence: 99%

Black Thyroid

Gamez

2018

Int J Surg Pathol

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Black Thyroid

Cited by 9 publications

References 17 publications

Papillary thyroid cancer in black thyroid: a case report and literature review

Papillary thyroid cancer in black thyroid: a case report and literature review

Black thyroid gland and tracheal cartilage

Black Thyroid

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