Health outcomes among rural minority populations are seldom examined. Our research studied mortality among urban and rural white, black, and Hispanic adults ages 45-64, comparing outcomes for each group. We found the mortality risk to be higher among both rural white and rural minority populations compared to urban whites; rural blacks were at higher risk of death than urban blacks. When personal characteristics and circumstances of these populations-such as level of education, presence of health insurance, and income above or below the poverty line-were held statistically equal, disparities were reduced or eliminated. Our study suggests that policies directed toward reducing differences related to education, poverty, and health insurance would go a long way toward eliminating the disparities in health status between urban and rural populations.