Bladder cancer: Evaluation of staging accuracy using dynamic MRI

Arora, Rajesh; Sokhi, Heminder; Fung, R.; Mulcahy, Kevin; Bankart, M John

doi:10.1016/j.crad.2011.05.019

Cited by 80 publications

(33 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[23][24][25] Detrusor muscle invasion was identified in the majority of patients in our study who underwent preoperative MRI; however, this finding can be observed in up to 54% of patients with conventional urothelial cell tumours. 26 In this study, from patients who were treated surgically with curative intent, almost half of patients had positive surgical margins and over half developed locally recurrent tumour. Comparatively, for conventional urothelial carcinoma, rates of only 4-10% for positive surgical margins and 18-19% for local recurrence following radical cystectomy are reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Plasmacytoid urothelial carcinoma (PUC): Imaging features with histopathological correlation

Chung

Schieda

Flood

et al. 2017

CUAJ

View full text Add to dashboard Cite

Cite as: Can Urol Assoc J 2017;11(1-2):E50-7. http://dx.doi.org/10.5489/cuaj.3789 Published online January 12, 2017 AbstractIntroduction: Plasmacytoid urothelial carcinoma (PUC) is a highgrade variant of conventional urothelial cell carcinoma. This study is the first to describe the imaging findings of PUC, which are previously unreported, using clinical and histopathological correlation. Methods: With internal review board approval, we identified 22 consecutive patients with PUC from 2007-2014. Clinical parameters, including age, gender, therapy, surgical margins, and longterm outcome, were recorded. Baseline imaging was reviewed by an abdominal radiologist who evaluated for tumour detectability/location/morphology, local staging, and presence/location of metastases. Pelvic peritoneal spread of tumour (defined as >5mm thick soft tissue spreading along fascial planes) was also evaluated. Followup imaging was reviewed for presence of local recurrence or metastases. Results: Median age at presentation was 74 years (range 51-86), with only three female patients. Imaging features of the primary tumour in this study were not unique for PUC. Muscle-invasive disease was present on pathology in 19/22 (86%) of tumours, with distant metastases in 2/22 (9%) at baseline imaging. Pelvic peritoneal spread of tumour was radiologically present in 4/20 (20%) at baseline. During followup, recurrent/residual tumour was documented in 16/22 (73%) patients and 7/16 (44%) patients eventually developed distant metastases. Median time to disease recurrence in patients who underwent curative surgery was three months (range 0-19). Conclusions: PUC is an aggressive variant of urothelial carcinoma with poor prognosis. Pelvic peritoneal spread of tumour as thick sheets extending along fascial planes may represent a characteristic imaging finding of locally advanced PUC.

show abstract

Section: Discussionmentioning

confidence: 99%

Plasmacytoid urothelial carcinoma (PUC): Imaging features with histopathological correlation

Chung

Schieda

Flood

et al. 2017

CUAJ

View full text Add to dashboard Cite

show abstract

“…Others have shown that Gd-DTPA enhancement in MRI, improved the accuracy of cancer staging in intramural bladder cancer [31], and others also report that with the use of Gdenhanced images, the sensitivity of detecting bladder cancer and the accuracy of staging of non-muscle invasive bladder tumors has been improved [32,33]. By contrast, Rajesh reported that this approach provided additional staging information for bladder cancer, but only in 3% of patients and concluded that routine use of Gd-enhanced images was not required [34].…”

Section: Initial Results For Bladder Tumor Stagingmentioning

confidence: 99%

Urinary Bladder Cancer: The Current and Potential Role of MR Imaging in Non-Distant Metastatic Lesions

Wang¹,

Guo²,

Zhou³

et al. 2013

JCT

View full text Add to dashboard Cite

Urinary bladder cancer is the second most common genitourinary malignancy in Westernized countries. A number of emerging imaging techniques have recently been reported in the literature for use in imaging bladder cancer. While the explicit application of MR imaging in bladder cancer especially in non-distant bladder cancer or bladder cancer localized in pelvic remains uncertain and awaits a thorough evaluation. Therefore, this article aims to make a systematic review of previous literature and provide a complete assessment of the value of MR as an evolving imaging tool in localized urinary bladder cancer application. Studies were conducted by searching the MEDLINE and PubMed databases up to 2012 using both medical subject heading (Mesh) and a free text method like "urinary bladder cancer", "magnetic resonance imaging" or "MRI", "diffusion weighted imaging" or "DWI". About 53 articles were selected and analyzed which were considered to be associated with the objective of this systematic review ( Table 1). Results showed that MRI especially the newer functional imaging technique like DWI may has a great potential role in localized bladder cancer like early detection, staging, evaluation of tumor aggressiveness and therapeutic responsiveness of patients in the assessment of urinary bladder cancer and so forth. Newer MRI has already proceeded promising results in bladder cancer application; and the explicit role of newer MRI in bladder cancer patients still needs further research and awaits to be thoroughly evaluated.

show abstract

“…4–6,17–20 The rFOV DWI technique produces fewer artifacts and less geometric distortion than traditional fFOV DWI with regard to several clinical applications. 7 Our study sought to compare the image quality, diagnostic accuracy, and ADC values of fFOV DWI and rFOV DWI with regard to patients with nonmuscle-invasive and those with muscle-invasive bladder tumors.…”

Section: Discussionmentioning

confidence: 99%

Nonmuscle-invasive and Muscle-invasive Urinary Bladder Cancer

Wang

Meng³

et al. 2016

Medicine

View full text Add to dashboard Cite

This study compared the imaging quality, diagnostic accuracy, and apparent diffusion coefficient (ADC) values of reduced field-of-view (rFOV) diffusion-weighted imaging (DWI) and full field-of-view (fFOV) single-shot echo-planar imaging with regard to patients with nonmuscle-invasive or muscle-invasive bladder cancer.Thirty-nine patients with 60 bladder tumors underwent rFOV and fFOV DWI in this internal review board-approved study. Pathologic and histologic grades were determined for all tumors. Two observers rated DWI image quality using a 4-point scale. Two radiologists who were blinded to the pathology findings reviewed 3 image sets (T2-weighted alone, T2-weighted plus fFOV DWI, and T2-weighted plus rFOV DWI) and assigned T stages and confidence levels for tumors of stage T2 or higher. The image quality scores for the 2 DWI sequences were assessed using the Wilcoxon signed-rank test. Differences in the diagnostic accuracy, sensitivity, and specificity for each image set were evaluated using the McNemar test. Differences in performance were analyzed by comparing the areas under the receiver-operating characteristic curves (ie, the Az values). A Mann–Whitney U test was used to compare the mean ADCs and the relationship between tumor stage and histologic grade.Image quality scores were significantly higher for rFOV (mean = 3.62) than for fFOV DWI (2.98; P < 0.001). The pooled diagnostic accuracies were 57%, 70%, and 78% for the T2-weighted alone images, the T2-weighted plus fFOV DWI images, and the T2-weighted plus rFOV DWI images, respectively. The overall accuracy, specificity, and Az for diagnosing T2 or higher stages were significantly improved by adding rFOV DWI (P < 0.05). The mean ADC values of the muscle-invasive and G3 grade bladder cancers were significantly lower than those of the nonmuscle-invasive tumors and G1 grade cancers, regardless of DWI sequence (P < 0.01).rFOV DWI is superior to fFOV DWI with respect to image quality and diagnostic accuracy. ADC values might be useful for distinguishing nonmuscle-invasive from muscle-invasive cancers, and G1 from G3 grade lesions.

show abstract

Bladder cancer: Evaluation of staging accuracy using dynamic MRI

Cited by 80 publications

References 18 publications

Plasmacytoid urothelial carcinoma (PUC): Imaging features with histopathological correlation

Plasmacytoid urothelial carcinoma (PUC): Imaging features with histopathological correlation

Urinary Bladder Cancer: The Current and Potential Role of MR Imaging in Non-Distant Metastatic Lesions

Nonmuscle-invasive and Muscle-invasive Urinary Bladder Cancer

Contact Info

Product

Resources

About