Bladder Carcinoma With Lymphoepithelioma-Like Differentiation: A Report of 9 Cases

Abstract

Lymphoepithelioma-like carcinoma is diagnosed in less advanced stages and has a more favorable long-term prognosis than other types of undifferentiated invasive carcinomas of the bladder. Our data and review of the literature suggest that lymphoepithelioma-like carcinoma should be treated stage by stage like other bladder carcinomas.

Lymphoepithelioma-like carcinoma of the urinary tract: a clinicopathological study of 30 pure and mixed cases

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] Besides nasopharyngeal carcinoma, EBV is frequently found in carcinomas arising in the lung, stomach, thymus, and salivary gland, but not in Lymphoepithelioma-like carcinoma of the urinary tract EF Tamas et al other locations. 2,4,6,7,9,13,15,16 These data confirm that EBV is not a prerequisite for development of lymphoepithelioma-like carcinoma. None of our cases showed any labeling for EBER by in situ hybridization.…”

“…This is in concordance with data in the literature showing no relation of the EBV to lymphoepithelioma-like carcinoma of the urinary tract. 1,3,5,7,8,11,12,16 It appears that abnormalities of p53 regulation are crucial in development of the lymphoepithelioma-like carcinoma of the urinary tract. 8,[17][18][19] Only a few relatively large series of lymphoepithelioma-like carcinoma have been reported in the urinary bladder.…”

“…Lymphoepithelioma-like carcinoma has been described in a variety of organs including salivary glands, thymus, lung, skin, stomach, uterine cervix, breast, prostate, and the urinary tract. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] In the urinary tract, they typically arise in the urinary bladder, although isolated cases have been reported in the renal pelvis, ureter, and urethra. 5,8 Lymphoepithelioma-like carcinoma of the urinary bladder, first reported by Zuckerberg et al in 1991, is uncommon with a reported incidence between 0.4 and 1.3% of all bladder carcinomas.…”

Lymphoepithelioma-like carcinoma of the bladder: A case report.

“…Favourable prognosis along with response to chemotherapy provides a potential to salvage bladder function in patients with locally advanced LELC. In a small number of patients with pure and predominant LELC treated with transurethral resection of bladder tumor (TUR) and chemotherapy only, no evidence of disease was achieved in a follow-up period between 2 to 18 years (8)(9)(10). In most of the reported cases, the platinum-based chemotherapies were performed in the treatment of both locally advanced and metastatic disease (9).…”

Lymphoepithelioma-like tumors: A review of literature and a clinical case of bladder carcinoma

“…для лечения ранних стадий рекомендуют ТУР и адъювантную лучевую терапию. Цистэктомии отдается предпочтение в лечении пациентов с фокальной LELC или на поздних стадиях за-болевания, так как прогноз для этих пациентов аналоги-чен обычным карциномам МП [32,44].…”