Lymphoepithelioma-like carcinoma of the bladder: A case report.

Stamatiou, Konstantinos; Christopoulos, Georgios; Tsavari, Aikaterini; Koulia, K; Manoloudaki, Kassiani; Vassilakaki, Thivi

doi:10.4081/aiua.2016.2.147

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…In the present case, surgery was not an option due to the patient's advanced age and personal preferences. LELCs generally have a more favourable prognosis than conventional urothelial carcinomas of the bladder; also, the prognosis has been reported to be significantly better for the pure/predominant as compared to the focal type [14,15]. Nonetheless, Tamas et al found no difference in the prognosis between pure and mixed LELCs treated by cystectomy, reporting a five-year recurrence-free risk of 59% (62% and 57%, for pure and mixed LELCs, respectively) [6].…”

Section: Discussionmentioning

confidence: 99%

Lymphoepithelioma-Like Carcinoma of the Urinary Bladder: A Case Report and Review of the Literature

Mitsogiannis¹,

Tzelves²,

Mitsogianni³

et al. 2022

Cureus

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Lymphoepithelioma-like carcinoma of the urinary bladder is a rare variant of infiltrating urothelial carcinoma. Diagnostic and therapeutic manipulations are not yet standardised, due to the rarity of the tumour, with surgery and chemotherapy being reported as potential therapeutic options. We report on a case of lymphoepithelioma-like carcinoma of the bladder in a 93-year-old female patient and discuss the pathological features and therapeutic options of the neoplasm. Due to her increased age and associated comorbidities such as hypertension, diabetes mellitus and ischemic heart disease, the patient was treated with transurethral resection of the tumour and subsequent cisplatin-based chemotherapy but unfortunately died of chemotherapy-related complications.

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Section: Discussionmentioning

confidence: 99%

Lymphoepithelioma-Like Carcinoma of the Urinary Bladder: A Case Report and Review of the Literature

Mitsogiannis¹,

Tzelves²,

Mitsogianni³

et al. 2022

Cureus

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Lymphoepithelioma-Like Bladder Carcinoma: A Diagnostic and Therapeutic Challenge. Contribution Using a New Case and Review of the Literature

Rodríguez-Cabello

Méndez-Rubio

Miguelañez

et al. 2017

Clinical Genitourinary Cancer

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Lymphoepithelioma-like, a variant of urothelial carcinoma of the urinary bladder: a case report and systematic review for optimal treatment modality for disease-free survival

et al. 2017

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BackgroundLymphoepithelioma-like carcinoma (LELC) is a rare high-grade carcinoma that resembles nasopharyngeal lymphoepithelioma and can occur throughout the body. First reported in 1991, bladder LELC has an incidence of about 1% of all bladder carcinomas. Due to its rare occurrence, prognoses and ideal treatment guidelines have not been clearly defined.MethodsA PubMed search was performed using two terms, “lymphoepithelioma-like carcinoma” and “bladder.” Review articles, articles in foreign languages, expression studies, and studies not performed in the bladder were excluded. We report a case of LELC of the bladder including treatment and outcome and performed a systematic review of all 36 available English literatures from 1991 to 2016 including the present case to identify factors affecting disease-free survival.ResultsOne hundred forty cases of bladder LELC were analyzed. The mean age of the patients was 70.1 years ranging from 43 to 90 years with 72% males and 28% females. Pure LELC occurs most often at 46% followed by mixed LELC 28% and predominant LELC 26%. EBV testing was negative in all cases tested. Mean follow-up length for all cases was 33.8 months with no evidence of disease in 62.2%, while 11.1% died of disease, 10.4% alive with metastasis, and 8.2% died without disease. 5.0% of cases had recurrence at an average of 31.3 months. Prognosis is significantly favorable for patients presenting with pure or predominant forms of LELC compared to mixed type (p < 0.0001). The treatment significantly associated with the highest disease mortality and lowest disease-free survival was TURBT alone when compared to any multi-modality treatment (p < 0.01).ConclusionWe conclude that the best treatment modality associated with the highest disease-free survival is multi-modal treatment including radical cystectomy.

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Lymphoepithelioma-like carcinoma of the bladder: A case report.

Cited by 3 publications

References 9 publications

Lymphoepithelioma-Like Carcinoma of the Urinary Bladder: A Case Report and Review of the Literature

Lymphoepithelioma-Like Carcinoma of the Urinary Bladder: A Case Report and Review of the Literature

Lymphoepithelioma-Like Bladder Carcinoma: A Diagnostic and Therapeutic Challenge. Contribution Using a New Case and Review of the Literature

Lymphoepithelioma-like, a variant of urothelial carcinoma of the urinary bladder: a case report and systematic review for optimal treatment modality for disease-free survival

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