Blaugraue Verfärbung von Haut und Bindehaut

Clinical and Forensic Aspects of the Different Subtypes of Argyria

“…Patients with OA have reported visual symptoms, most commonly nyctalopia [ 54 ], and presented with concomitant comorbidities, such as glaucoma [ 151 , 163 ], cataract [ 114 , 149 , 218 , 262 ], diabetic retinopathy [ 111 ], as well as posterior eye segment changes somewhat coherent with the functional complaints [ 157 , 158 ], but without direct link to the silver deposition itself [ 156 , 162 , 263 ]. This inconsistency, alongside several OA patients lacking any visual complaints, has contributed to some consensus regarding the seemingly innocuous silver deposition in the eye, though this claim still needs a more robust foundation [ 21 , 113 , 261 , 263 , 264 ].…”

“…Liver toxicity following silver deposition has also been suggested but, apart from transient hepatic enzyme elevation with no clinical significance, no evidence of pathological liver processes caused by silver accumulation has been found [ 5 , 55 , 182 , 223 , 269 ]. Indeed, most argyric patients, as well as individuals exposed to silver without clinical signs of argyria, present with corresponding laboratory parameters within reference values for healthy people [ 6 , 48 , 49 , 51 , 52 , 66 , 69 , 132 , 144 , 211 , 212 , 218 , 230 , 263 ]. Argyric patients might require special attention when radiotherapy is required after a report of a radiation dermatitis possibly explained/aggravated by the dermal silver deposition [ 215 ].…”

“…Slit-lamp biomicroscopy is the first step in the diagnostic approach of OA, revealing a particulate pattern in the cornea, but this technique, possibly complemented with confocal microscopy, should be employed for exposure monitoring, or if GA is suspected even without clinical evidence of OA, since cornea’s Descemet’s membrane displays silver deposits quite early following either systemic or local exposition, making slit-lamp examination a sensitive index for both GA and OA [ 102 , 117 , 118 , 120 , 157 , 162 , 199 ]. Other ophthalmological tests have also been reported, such as fluorescein angiography, optical coherence tomography, and electroretinogram, but their purpose so far has been mainly to find eye structural and functional changes related to argyria rather than establishing the diagnosis and with extrapolations limited due to the number and type of studies [ 149 , 156 , 157 , 158 , 218 , 222 ].…”

Okuläre Argyrose nach langjähriger Applikation von Wimpern- und Augenbrauenfarbe

“…In einer Reihe von Fallberichten wurden Silberreste in Haut und Schleimhaut, aber auch in inneren Organen nach der systemischer Einnahme von silberhaltigen Medikamenten in oraler Form nachgewiesen [1,11]. Auch ophthalmologisch wurde bereits von Silberresten im Bereich der Augenadnexe, der Bindehaut und Hornhaut (im Bereich der Descemet-Membran) sowie auch intraokular u. a. im Kammerwinkel nach längerfristiger topischer oder systemischer Einnahme von silberhaltigen Medikamenten oder auch der beruflichen Exposition gegenüber Silber berichtet [2,4,[6][7][8][9][10].…”