Bleaching of plasmon-resonance absorption of gold nanorods decreases efficiency of cell destruction

Rudnitzki, Florian; Bever, Marco; Rahmanzadeh, Ramtin; Brieger, Katrin; Endl, Elmar; Groll, Jürgen; Hüttmann, Gereon

doi:10.1117/1.jbo.17.5.058003

Cited by 17 publications

(20 citation statements)

References 31 publications

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“…We believe that the divergence in these curves is due to permanent bleaching of the nanorods in the interaction region leading to depletion of at least some of the nanorods. The observed damage threshold is lower than the 5 mJ/cm 2 found for 10 nm × 41 nm gold nanorods using transmission measurements [29]. However, this discrepancy may be caused by the different size and aspect ratio of the nanorods.…”

Section: Resultsmentioning

confidence: 63%

“…The threshold fluences for gold nanorods (~32 mJ/cm 2 ) [22,26] and nanoshells (4-42 mJ/cm 2 ) [22,27,28] are somewhat lower and these particles have the additional advantage that they can operate in the near-IR region of the spectrum. They are, however, less stable under high optical fluence, and can exhibit permanent bleaching associated with melting induced shape change and fragmentation [29]. …”

Section: Introductionmentioning

confidence: 99%

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Gold nanoparticle targeted photoacoustic cavitation for potential deep tissue imaging and therapy

Roy

Murray

2012

Biomed. Opt. Express

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The laser generation of vapor bubbles around plasmonic nanoparticles can be enhanced through the application of an ultrasound field; a technique referred to as photoacoustic cavitation. The combination of light and ultrasound allows for bubble formation at lower laser fluence and peak negative ultrasound pressure than can be achieved using either modality alone. The growth and collapse of these bubbles leads to local mechanical disruption and acoustic emission, and can potentially be used to induce and monitor tissue therapy. Photoacoustic cavitation is investigated for a broad range of ultrasound pressures and nanoparticle concentrations for gold nanorods and nanospheres. The cavitation threshold fluences for both nanoparticle types are found to drastically reduce in the presence of an ultrasound field. The results indicate that photoacoustic cavitation can potentially be produced at depth in biological tissue without exceeding the safety limits for ultrasound or laser radiation at the tissue surface.

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Section: Resultsmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Gold nanoparticle targeted photoacoustic cavitation for potential deep tissue imaging and therapy

Roy

Murray

2012

Biomed. Opt. Express

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“…Also, the heat conduction from the particle to the surrounding water breaks during the formation of the vapor bubble. Assuming adiabatic conditions, the energy deposition within the AuNP ∆E p can be calculated from the integral over the irradiance H of the laser pulse as determined by Rudnitzki et al .

∆ E_{p} ((), t) = \int_{t_{v}}^{t} σ_{abs} ∙ H ((), t^{'}) d t^{'} .

…”

Section: Methodsmentioning

confidence: 99%

siRNA release from gold nanoparticles by nanosecond pulsed laser irradiation and analysis of the involved temperature increase

Rudnitzki

Feineis

Rahmanzadeh

et al. 2018

Journal of Biophotonics

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Nanosecond pulsed laser irradiation can trigger a release of nucleic acids from gold nanoparticles, but the involved nanoeffects are not fully understood yet. Here we investigate the release of coumarin labeled siRNA from 15 to 30 nm gold particles after nanosecond pulsed laser irradiation. Temperatures in the particle and near the surface were calculated for the different radiant exposures. Upon irradiation with laser pulses of 4 nanosecond duration release started for both particle sizes at a calculated temperature increase of approximately 500 K. Maximum coumarin release was observed for 15 nm particles after irradiation with radiant exposure of 80 mJ cm and with 32 mJ cm for 30 nm particles. This corresponds to a temperature increase of 815 and 900 K, respectively. Our results show that the molecular release by nanosecond pulsed irradiation is based on a different mechanism compared to continuous or femtosecond irradiation. Local temperatures are considerably higher and it is expected that bubble formation plays a crucial role in release and damage to cellular structures.

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“…In the case of NRs, the two characteristic SPR modes are transverse and longitudinal SPR or normal and parallel to the long axes of the NRs, respectively, and take place at specific wavelength bands, called plasmon bands [1][2] . For noble metals, the plasmon bands are positioned in the UV -Visible range, features that are advantageous in numerous applications [3][4][5][6][7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

Enhanced anisotropy of gold nanorods-polymer composite films for optical applications

Stoenescu¹,

Bădilescu²,

Packirisamy³

et al. 2012

Photonics North 2012

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The strong optical absorption, scattering and local electric field enhancement associated with the longitudinal Surface Plasmon Resonance (SPR) of gold nanorods (AuNRs) have important applications in imaging, sensing, nonlinear optics, thermal therapy and data encoding. The longitudinal SPR mode can be optimally excited only in the NRs that are most aligned with the electric field of a linearly polarized incident light. Thus, in cast polymer based nanorod composite films, where the NRs orientation is random, only a fraction of the embedded NRs is actually usable to the maximal extent for the intended applications. To enhance the degree of alignment of the AuNRs by uniaxial stretching and increase the application efficiency, we have improved the polymer matrix with respect to plastic deformation and designed a suitable drawing device to reduce the fracture risks of the polymer. The resulting nanocomposite film was characterized by Scanning Electron Microscopy (SEM) and by spectroscopy using linearly polarized light in the UV-Visible range. The linear dichroic ratio of the stretched nanocomposite film was calculated based on the ratio of the peak absorbance of the incident light parallelly polarized, to that of the light polarized perpendicularly to the NRs long axes.

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Bleaching of plasmon-resonance absorption of gold nanorods decreases efficiency of cell destruction

Cited by 17 publications

References 31 publications

Gold nanoparticle targeted photoacoustic cavitation for potential deep tissue imaging and therapy

Gold nanoparticle targeted photoacoustic cavitation for potential deep tissue imaging and therapy

siRNA release from gold nanoparticles by nanosecond pulsed laser irradiation and analysis of the involved temperature increase

Enhanced anisotropy of gold nanorods-polymer composite films for optical applications

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