1996
DOI: 10.1016/s0161-6420(96)30639-8
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Bleb-related Endophthalmitis after Trabeculectomy with Mitomycin C

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Cited by 280 publications
(152 citation statements)
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“…However, as Higginbotham et al 30 suggested, inferior trabeculectomy performed with MMC carries a significantly increased risk of bleb-related endophthalmitis, possibly because chronic mechanical irritation by the lower lid margin from repetitive blinking and eye movements weakens the structural integrity of an already thin, cystic bleb surface. Additional disruption of the epithelial surface, secondary to prolonged interpalpebral exposure and drying, may further alter the natural protective function of the conjunctiva, allowing increased access to the intraocular cavity of potential pathogens present on the lid margin and in the tear lake.…”
Section: Discussionmentioning
confidence: 99%
“…However, as Higginbotham et al 30 suggested, inferior trabeculectomy performed with MMC carries a significantly increased risk of bleb-related endophthalmitis, possibly because chronic mechanical irritation by the lower lid margin from repetitive blinking and eye movements weakens the structural integrity of an already thin, cystic bleb surface. Additional disruption of the epithelial surface, secondary to prolonged interpalpebral exposure and drying, may further alter the natural protective function of the conjunctiva, allowing increased access to the intraocular cavity of potential pathogens present on the lid margin and in the tear lake.…”
Section: Discussionmentioning
confidence: 99%
“…7 MMC is a potent suppressor of fibroblast proliferation when used intraoperatively, especially in cases in which previous surgery has failed, and has a greater rate of success and induces a greater reduction of IOP. 19,20 Angiogenesis is a process of new blood vessel formation and is considered as a key element in the proliferative phase of wound healing and scar tissue formation. VEGF inhibition not only reduced the amount of scar formed but also improved the quality of the scar tissue by shifting the collagen fibril distribution in a manner that is similar to that of normal tissue.…”
Section: Discussionmentioning
confidence: 99%
“…A primeira dificuldade quando se estuda este assunto na literatura é a falta de critério dos autores no que concerne a estes conceitos e os critérios de exclusão e inclusão das amostragens selecionadas. Alguns autores deixam claro que o envolvimento do ví-treo não foi pré-requisito para o diagnóstico de endoftalmite, o que para outros era indispensável (11,12,14) , inclusive com comprovação ecográfica (15) . Tais casos, então, deveriam ser caracterizados como portadores de panoftalmite, como o caso apresentado, e não como endoftalmite.…”
Section: Discussionunclassified
“…O índice de cultura conjuntival positiva parece ser mais baixo (64,3%). Quando há o envolvimento da cavidade vítrea, a cultura do aspirado vítreo é positiva na maioria dos casos (83,0%, 77,0%, 83,3%) (15) , mas em alguns trabalhos foi significativa a ocorrência de culturas negativas (45,0%, 30,8%) (14) , o que se deu também no caso apresentado. Tem sido referido na literatura que olhos com cultura negativa tendem a ter um prognóstico visual melhor do que olhos infectados.…”
Section: Discussionunclassified