Blends and composites of exopolysaccharides; properties and applications: A review

Hussain, Abid; Zia, Khalid Mahmood; Tabasum, Shazia; Noreen, Aqdas; Ali, Muhammad; Iqbal, Rehana; Zuber, Mohammad

doi:10.1016/j.ijbiomac.2016.09.104

Cited by 123 publications

(75 citation statements)

References 272 publications

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“…On the other hand, it has been shown that, topical use of Lactobacilli can directly balance skin microflora [10]. Moreover, Lactobacilli secrete extracellular polysaccharides (EPS) that plays a significant role in improving rheology, texture and oral sensory in fermented foods [11][12][13][14]. Their physiological effects on human health have been widely examined including antitumor, antioxidant and immune-modulating activities [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Anti-elastase and anti-collagenase potential of Lactobacilli exopolysaccharides on human fibroblast

Shirzad

Hamedi

Motevaseli

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Polysaccharides could be used as biodegradable and biocompatible polymers for scaffolds and carriers matrix. Numerous algal, fungi and herbal polysaccharides can attenuate degradation of skin matrix by the inhibition of elastase, collagenase and matrix metalloproteinases (MMPs). In this study, we investigate anti-elastase and anti-collagenase potential of Lactobacilli exopolysaccharides (LEPS) on normal human fibroblast. Among 60 Lactobacilli isolated from herbal plants and dairy products, selected LEPS showed high anti-collagenase (up to 100%), anti-elastase (up to 87%) and antioxidant activity (up to 60%). Most of them had no cytotoxicity effect on fibroblast, and some of them promote cell proliferation (up to 10%). In scratch assay, all the investigated EPS stimulated wound healing process in fibroblast (up to 99%). MMP1, MMP2, MMP3, MMP9 and MMP10 were down-regulated significantly and TIMP1 and TIMP2 were up-regulated slightly in LEPS of B9-1 from L. casei with high anti-collagenase and anti-elastase activity; however, no meaningful alteration was observed in MMP expression level for LEPS of P35 from L. plantarum with low anti-collagenase and anti-elastase activity. By consideration of high anti-collagenase, anti-elastase, antioxidant activity and wound healing of LEPS, they could be considered as good candidate of skin anti-aging agents for tissue engineering and skin regeneration scaffolds.

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Section: Introductionmentioning

confidence: 99%

Anti-elastase and anti-collagenase potential of Lactobacilli exopolysaccharides on human fibroblast

Shirzad

Hamedi

Motevaseli

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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“…Nevertheless, EPSs should be carefully used for tissue engineering due to their poor mechanical properties. For that reason, they are mainly used in composites for this purpose [ 29 ].…”

Section: Eps Selection Rational Design and In Vivo Resultsmentioning

confidence: 99%

“…As a consequence, several reviews have been published covering and exploring EPSs potential. Hussain et al reviewed the possibilities of blending different exopolysaccharides to improve their mechanical and biological properties [ 29 ]. Specifically, blends with xanthan gum, curdlan, hyaluronic acid, and dextran were discussed, highlighting how their different combinations can be used to obtain versatile materials depending on the final application.…”

Section: Introductionmentioning

confidence: 99%

Microbial Exopolysaccharides as Drug Carriers

Cardea

2020

Polymers

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Microbial exopolysaccharides are peculiar polymers that are produced by living organisms and protect them against environmental factors. These polymers are industrially recovered from the medium culture after performing a fermentative process. These materials are biocompatible and biodegradable, possessing specific and beneficial properties for biomedical drug delivery systems. They can have antitumor activity, they can produce hydrogels with different characteristics due to their molecular structure and functional groups, and they can even produce nanoparticles via a self-assembly phenomenon. This review studies the potential use of exopolysaccharides as carriers for drug delivery systems, covering their versatility and their vast possibilities to produce particles, fibers, scaffolds, hydrogels, and aerogels with different strategies and methodologies. Moreover, the main properties of exopolysaccharides are explained, providing information to achieve an adequate carrier selection depending on the final application.

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“…It has been found that a number of marine microorganisms synthesize exopolysaccharides (EPSs) [1]. Marine microbial EPSs are secreted into the surrounding environment [2], which protect cells via stabilizing membrane structure against external environmental pressures and/or serve as carbon and energy reserves [3]. Most of marine microbial EPSs are heteropolysaccharides, which are composed of three or four different monosaccharides that may be pentoses, hexoses, amino sugars, or uronic acids and are arranged in groups of ten or less to form repeating units [1].…”

Section: Introductionmentioning

confidence: 99%

Promotion of Wound Healing and Prevention of Frostbite Injury in Rat Skin by Exopolysaccharide from the Arctic Marine Bacterium Polaribacter sp. SM1127

et al. 2020

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Many marine microorganisms synthesize exopolysaccharides (EPSs), and some of these EPSs have been reported to have potential in different fields. However, the pharmaceutical potentials of marine EPSs are rarely reported. The EPS secreted by the Artic marine bacterium Polaribacter sp. SM1127 has good antioxidant activity, outstanding moisture-retention ability, and considerable protective property on human dermal fibroblasts (HDFs) at low temperature. Here, the effects of SM1127 EPS on skin wound healing and frostbite injury prevention were studied. Scratch wound assay showed that SM1127 EPS could stimulate the migration of HDFs. In the full-thickness cutaneous wound experiment of Sprague–Dawley (SD) rats, SM1127 EPS increased the wound healing rate and stimulated tissue repair detected by macroscopic observation and histologic examination, showing the ability of SM1127 EPS to promote skin wound healing. In the skin frostbite experiment of SD rats, pretreatment of rat skin with SM1127 EPS increased the rate of frostbite wound healing and promoted the repair of the injured skin significantly, indicating the good effect of SM1127 EPS on frostbite injury prevention. These results suggest the promising potential of SM1127 EPS in the pharmaceutical area to promote skin wound healing and prevent frostbite injury.

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Blends and composites of exopolysaccharides; properties and applications: A review

Cited by 123 publications

References 272 publications

Anti-elastase and anti-collagenase potential of Lactobacilli exopolysaccharides on human fibroblast

Anti-elastase and anti-collagenase potential of Lactobacilli exopolysaccharides on human fibroblast

Microbial Exopolysaccharides as Drug Carriers

Promotion of Wound Healing and Prevention of Frostbite Injury in Rat Skin by Exopolysaccharide from the Arctic Marine Bacterium Polaribacter sp. SM1127

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