Bleomycin: effect on satellite DNA in mouse fibroblasts

Madreiter, H; Osieka, R.; Wittekind, Ch.; Kaden, Peter; Mittermayer, Christian

doi:10.1007/bf00461654

Cited by 2 publications

(3 citation statements)

References 26 publications

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“…2,3 In vitro experiments have shown that bleomycin can significantly disrupt cell division of fibroblasts. 4 These mechanisms of action of bleomycin are consistent with our clinical results.…”

Section: Discussionsupporting

confidence: 90%

“…The mechanism of action of bleomycin is to bind to the DNA of the cell, causing the DNA strands to break, thereby blocking the division and proliferation of the cell; phase M cells are most sensitive to bleomycin 2,3 . In vitro experiments have shown that bleomycin can significantly disrupt cell division of fibroblasts 4 . These mechanisms of action of bleomycin are consistent with our clinical results.…”

Section: Discussionsupporting

confidence: 87%

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The combined application of bleomycin and triamcinolone for the treatment of keloids and hypertrophic scars: An effective therapy for treating refractory keloids and hypertrophic scars

Luo

2023

Skin Research and Technology

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Background: Keloids and hypertrophic scars frustrate patients by the deformity of appearance and organ dysfunction. Many modalities had been tried in clinic practice, but the results are unsatisfied.Objective: We retrospectively analysed the combined application of bleomycin and triamcinolone for the treatment of keloids and hypertrophic scars. Methods:The combination of bleomycin and triamcin acetonide was applied to the treatment of keloids and hypertrophic scars, 86 cases accepted the treatment.Follow-up 2-5 years after treatment. Results:(1) The pain of scars and itching symptoms have basically subsided through treatment. (2) After drug injection treatment, the keloid began to shrink, some of the keloids disappeared. (3) Small keloids did not recur after treatment. Large keloids had local recurrence after treatment. When further treatment was given, the recurrence disappeared. Conclusion:The combined application of bleomycin and triamcin acetonide can effectively cure keloids and hypertrophic scars.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 87%

The combined application of bleomycin and triamcinolone for the treatment of keloids and hypertrophic scars: An effective therapy for treating refractory keloids and hypertrophic scars

Luo

2023

Skin Research and Technology

View full text Add to dashboard Cite

show abstract

“…Bleomycin is an antitumor drug, which binds to the DNA of the cell, causing the DNA strand to break, thereby blocking the division and proliferation of the cell; M-phase cells are most sensitive to bleomycin [13,14]. In vitro experiments have shown that bleomycin can significantly disrupt the mitosis of fibroblasts [15]. We use bleomycin clinically for the treatment of diseases such as hemangioma and vascular malformations [16][17][18].…”

Section: Discussionmentioning

confidence: 99%

The combined application of bleomycin with triamcinolone acetonide in port wine stains: inhibiting proliferation and recurrence of port wine stains

Luo

2023

Maxillofac Plast Reconstr Surg

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Background Port wine stains slowly grow thicker over time, nodules appear on the surface, and the color slowly deepens from pink to purple. Even after laser treatment, some port wine stains will recur and slowly grow, and the erythema appears again. The purpose of this study was to investigate the effectiveness of bleomycin in combination with triamcinolone acetonide in the treatment of inhibiting the proliferation and recurrence of port wine stains. Results Histopathological change: Before treatment, dense capillaries were distributed within the lesion, and blood fills the lumen. Lack of normal skin structure: After bleomycin and triamcinolone acetonide injection, the number of capillaries was significantly reduced, and fibrosis occurred in tissues. Changes in facial morphology: After treatment, the port wine stains became thinner, the asymmetry of the face was effectively improved, and the appearance have been significantly improved. After 5 years of follow-up, there were no recurrent cases. Conclusion Bleomycin and triamcinolone acetonide injection can effectively inhibit the proliferation of port wine stains and prevent port wine stains from recurring after treatment.

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Bleomycin: effect on satellite DNA in mouse fibroblasts

Cited by 2 publications

References 26 publications

The combined application of bleomycin and triamcinolone for the treatment of keloids and hypertrophic scars: An effective therapy for treating refractory keloids and hypertrophic scars

The combined application of bleomycin and triamcinolone for the treatment of keloids and hypertrophic scars: An effective therapy for treating refractory keloids and hypertrophic scars

The combined application of bleomycin with triamcinolone acetonide in port wine stains: inhibiting proliferation and recurrence of port wine stains

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