In this paper, a comprehensive evaluation factor model of a truck dispatching system in open-pit mines is constructed from the three dimensions of optimal route, traffic flow planning, and real-time dispatching, and the final combined weight of the factor is determined according to game theory. On this basis, a comprehensive evaluation model of a truck dispatching system in open-pit mines based on gray relational analysis—technology for order preference by similarity to an ideal solution (GRA-TOPSIS) is established. Taking the truck dispatching system in five open-pit mines as the research background, the advantages and disadvantages of the dispatching system were comprehensively evaluated, and the differences between the dispatching systems were analyzed using the radar chart method. The research shows that the evaluation results of the comprehensive evaluation model of the truck dispatching system in open-pit mines based on GRA-TOPSIS are in line with the reality, which is more conducive to analyzing and comparing the advantages and disadvantages of the systems, effectively identifying the differences of various systems, and making the evaluation of truck dispatching systems more scientific. The research results of this paper broaden the evaluation of truck dispatching systems and provide a theoretical basis for the optimization of truck dispatching systems.