Individuals with visual impairments (VI) may face difficulties fitting in a distance education (DE) program mainly because of accessibility issues and a pervading lack of readiness. The main question was which difficulties and, specifically, which specific aspects of participants’ readiness could jeopardize their attendance in a DE program. The aims of this study were to examine the readiness of individuals with VI for participation in DE and the possible relationships between participants’ readiness for participation and their personal characteristics. A 42-item questionnaire has been developed to examine readiness for participation through five sub-scales referring to motivation, skills, self-management, interaction, and access to technological means (including means of assistive technology). The findings revealed a slightly positive degree of readiness as far as participants’ motivation, perception of their skills, and self-management are concerned and an approximate neutral degree of readiness regarding the aspects of interaction and access to technological means in the context of a DE program. The greater the educational level and the frequency of computer usage, the more positive the readiness for participation.