Block and Graft Copolymers of Poly(ethylene glycol) and Poly(dimethylsiloxane) for Blood Contacting Biomedical Materials Applications

Jukarainen, Harri; Clarson, Stephen J.; Seppälä, Jukka; Retzinger, Gregory S.; Ruohonen, Jarkko K.

doi:10.1007/s12633-011-9104-9

Cited by 9 publications

(9 citation statements)

References 16 publications

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“…The PDMS-g-PEO copolymers (having a PEO content from 58 to 80 wt%) can behave like molecular brushes, which are able to reduce the fibrinogen adsorption on the surface. 288 In addition to PDMS-g-PEO copolymers, a type of triblock copolymer, namely, PEO-polybutadiene-PEO (PEO-PB-PEO), has been used to modify medical grade Pellethane, Tygon polyurethanes, PDMS and polycarbonate. A highly stable, protein-repellant PEO layer was formed on the surface by the adsorption and g-irradiation of these PEO-PB-PEO triblock copolymers.…”

Section: Surface Modification Of Artificial Vascular Grafts By Pegmentioning

confidence: 99%

Surface modification and endothelialization of biomaterials as potential scaffolds for vascular tissue engineering applications

et al. 2015

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Surface modification and endothelialization of vascular biomaterials are common approaches that are used to both resist the nonspecific adhesion of proteins and improve the hemocompatibility and long-term patency of artificial vascular grafts. Surface modification of vascular grafts using hydrophilic poly(ethylene glycol), zwitterionic polymers, heparin or other bioactive molecules can efficiently enhance hemocompatibility, and consequently prevent thrombosis on artificial vascular grafts. However, these modified surfaces may be excessively hydrophilic, which limits initial vascular endothelial cell adhesion and formation of a confluent endothelial lining. Therefore, the improvement of endothelialization on these grafts by chemical modification with specific peptides and genes is now arousing more and more interest. Several active peptides, such as RGD, CAG, REDV and YIGSR, can be specifically recognized by endothelial cells. Consequently, graft surfaces that are modified by these peptides can exhibit targeting selectivity for the adhesion of endothelial cells, and genes can be delivered by targeting carriers to specific tissues to enhance the promotion and regeneration of blood vessels. These methods could effectively accelerate selective endothelial cell recruitment and functional endothelialization. In this review, recent developments in the surface modification and endothelialization of biomaterials in vascular tissue engineering are summarized. Both gene engineering and targeting ligand immobilization are promising methods to improve the clinical outcome of artificial vascular grafts.

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Section: Surface Modification Of Artificial Vascular Grafts By Pegmentioning

confidence: 99%

Surface modification and endothelialization of biomaterials as potential scaffolds for vascular tissue engineering applications

et al. 2015

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“…The hydrosilation coupling reaction was catalyzed using a homogeneous organoplatinum Karstedt's catalyst purchased from United Chemical Technologies (PC072, 2 wt % platinum‐divinyltetramethyl disiloxane complex in xylene) . To synthesize the diblocks, PEO and PDMS were dissolved in toluene (ACS grade, purchased from EMD) at ∼ 20 wt % solids; the PEO was added at ∼30% stoichiometric excess to ensure that all of the hydride end groups reacted to completion.…”

Section: Methodsmentioning

confidence: 99%

Coatings with thermally switchable surface energy produced from poly(ethylene oxide)‐poly(dimethylsiloxane) block copolymer films

Davis

2015

J Polym Sci B Polym Phys

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This work explores coatings with thermally switchable wetting behavior, based on block copolymers that possess both hydrophilic and hydrophobic segments. The amphiphilic block copolymers were synthesized by coupling allyl‐ended poly(ethylene oxide) (PEO) and hydride‐ended poly(dimethylsiloxane) (PDMS) oligomers via a Pt catalyst. One near‐symmetric diblock possessed an order‐disorder transition temperature (TODT) of 64 °C. When cooled through TODT in ambient air, the PDMS domains wet the film's surface, producing a hydrophobic coating with a water contact angle (CA) = 90°. However, when cooled in humidified air, hydrophilic PEO domains form at the surface, yielding CA = 30–40°. The coatings can be reversibly switched between the two states by reheating above TODT, in the appropriate environment, and then cooling, rapidly generating the desired room‐temperature surface wettability. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2016, 54, 135–140

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“…13 Due to these unique properties, POS, and in particular PDMS, are used in diverse applications, for example in semiconductor devices, aerospace, decorative coatings, biomaterials, as mold release agents, antifoam and foaming agents, personal care products, additive materials, high performance elastomers and deformers and are ubiquitous in our homes and lives. [14][15][16] The rst hydrosilylation reaction of trichlorosilane and 1-octene in the presence of acetyl epoxide was reported by Sommer et al in 1947. 17 Since then, hydrosilylation has become one of the most powerful reactions in silicone polymer and surface chemistry.…”

Section: Introductionmentioning

confidence: 93%

Hydrosilylation as an efficient tool for polymer synthesis and modification with methacrylates

Risangud

Anastasaki

et al. 2015

RSC Adv.

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Block and Graft Copolymers of Poly(ethylene glycol) and Poly(dimethylsiloxane) for Blood Contacting Biomedical Materials Applications

Cited by 9 publications

References 16 publications

Surface modification and endothelialization of biomaterials as potential scaffolds for vascular tissue engineering applications

Surface modification and endothelialization of biomaterials as potential scaffolds for vascular tissue engineering applications

Coatings with thermally switchable surface energy produced from poly(ethylene oxide)‐poly(dimethylsiloxane) block copolymer films

Hydrosilylation as an efficient tool for polymer synthesis and modification with methacrylates

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