Blockade of adhesion molecule lymphocyte function–associated antigen-1 improves long-term heart allograft survival in mixed chimeras

Pilat, Nina; Sabler, Philipp; Klaus, Christoph; Mahr, Benedikt; Unger, Lukas; Hock, Karin; Wiletel, Mario; Schwarz, Christoph; Kristo, Ivan; Regele, Heinz; Wekerle, Thomas

doi:10.1016/j.healun.2018.03.016

Search citation statements

Order By: Relevance

Paper Sections

Select...

Mixed Chimerism1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2019

2024

Publication Types

Select...

Book2

Article1

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

(1 citation statement)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A mouse model with pretransplant BMT as well as CD28/B7 and lymphocyte function associated antigen-1 antagonism followed by skin transplantation 4 to 6 weeks after treatment and subsequently heart transplantation 2 weeks later showed induction of long-term donor-specific tolerance of heart allografts, but chronically rejected skin grafts of the same background as the BMT and heart. 17 Although this brings both costimulation blockade and mixed chimerism via BMT closer to clinical relevance, the requirement of receiving a BMT and costimulation treatment 1 to 2 months before a heart transplant remains a significant limitation.…”

Section: Mixed Chimerismmentioning

confidence: 99%