2005
DOI: 10.1095/biolreprod.104.034108
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Blockade of CD86 Signaling Facilitates a Th2 Bias at the Maternal-Fetal Interface and Expands Peripheral CD4+CD25+ Regulatory T Cells to Rescue Abortion-Prone Fetuses1

Abstract: Intervention in B7 (CD80/CD86)/B7-ligand (CD28/CTLA-4) pathways is an effective way of preventing unwanted immune responses, such as allograft rejection. Pregnancy maintenance represents maternal tolerance to the fetal allograft, which is accompanied by a type 2 helper cell (Th2) bias at the maternal-fetal interface. Here, the costimulatory signal of CD86 was selectively blocked, and that of CD80 was kept unimpaired by administration of anti-murine CD86 monoclonal antibody at the early gestational stage in abo… Show more

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Cited by 106 publications
(78 citation statements)
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“…Knowing that no IL-2 is available at the fetalmaternal interface in mice and humans (41,65,66) and IL-2 is necessary for Treg to survive and proliferate in vivo, we hypothesized that Treg need to migrate to the decidua after generation or expansion. Data from mice support this hypothesis (61,86).…”
Section: Cd25mentioning
confidence: 99%
“…Knowing that no IL-2 is available at the fetalmaternal interface in mice and humans (41,65,66) and IL-2 is necessary for Treg to survive and proliferate in vivo, we hypothesized that Treg need to migrate to the decidua after generation or expansion. Data from mice support this hypothesis (61,86).…”
Section: Cd25mentioning
confidence: 99%
“…3 A failure to establish such an immune milieu or exhibiting a T H 1 bias, such as the overexpression of interferon (IFN)-c or tumor-necrosis factora, is associated with recurrent spontaneous abortion in humans. 4,5 It also has been proven that regulatory T (Treg) cells increase during the first and second trimesters and peak in the second trimester in human decidua and peripheral blood. 6 These changes at the beginning of pregnancy suggest that T cells may play an important role in the establishment of fetal tolerance during early pregnancy.…”
Section: Introductionmentioning
confidence: 99%
“…While CD4 + Foxp3 + regulatory T cells are abundant in decidual tissue during normal pregnancy to maintain the tolerance of the maternal-fetal interface, there are fewer T helper type 1 (Th1) cells secreting interferon-γ (IFN-γ) in decidual tissue during early pregnancy compared with levels in blood (Mjosberg et al, 2010). In addition, cytokine polarization in T helper type 2 (Th2) cells is crucial for ensuring tolerance at the maternal-fetal interface (Zhu et al, 2005). Interestingly, natural killer (NK) cells comprise the largest population of immune cells in human decidual tissue.…”
Section: Introductionmentioning
confidence: 99%