1997
DOI: 10.1016/s0022-2143(97)90181-5
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Blockade of cytochrome P-450 epoxygenase pathway attenuates the natriuresis of NG-monomethyl-l-arginine infusion in the spontaneously hypertensive rat

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“…In the spontaneously hypertensive rat, however, the anti-natriuresis induced by L-NMMA infusion can be significantly inhibited by ketoconazole (an inhibitor of renal activity of cytochrome P-450 epoxygenase) but not by indomethacin (an inhibitor of cyclooxygenase activity), suggesting that the anti-natriuretic response of L-NMMA infusion is mediated at least partly by cytochrome P-450 metabolites of the epoxygenase pathway [85].…”
Section: Salt and Watermentioning
confidence: 99%
“…In the spontaneously hypertensive rat, however, the anti-natriuresis induced by L-NMMA infusion can be significantly inhibited by ketoconazole (an inhibitor of renal activity of cytochrome P-450 epoxygenase) but not by indomethacin (an inhibitor of cyclooxygenase activity), suggesting that the anti-natriuretic response of L-NMMA infusion is mediated at least partly by cytochrome P-450 metabolites of the epoxygenase pathway [85].…”
Section: Salt and Watermentioning
confidence: 99%