2019
DOI: 10.1186/s12964-019-0324-8
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Blockade of glycolysis-dependent contraction by oroxylin a via inhibition of lactate dehydrogenase-a in hepatic stellate cells

Abstract: BackgroundContraction of hepatic stellate cells (HSCs) plays an important role in the pathogenesis of liver fibrosis by regulating sinusoidal blood flow and extracellular matrix remodeling. Here, we investigated how HSC contraction was affected by the natural compound oroxylin A, and elucidated the underlying mechanism.MethodsCell contraction and glycolysis were examined in cultured human HSCs and mouse liver fibrosis model upon oroxylin A intervention using diversified cellular and molecular assays, as well a… Show more

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Cited by 45 publications
(35 citation statements)
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“…Oroxylin A prevented from angiogenesis of LSECs in liver fibrosis via inhibition of the YAP/HIF-1 α signaling pathway [ 102 ]. Moreover, inhibition of glycolysis-dependent contraction via suppression of lactate dehydrogenase-A (LDH-A) and induction of apoptosis via endoplasmic reticulum (ER) stress in HSCs were involved in antihepatic fibrosis effects of oroxylin A [ 103 , 104 ]. Apart from these signaling pathways, oroxylin A also alleviated CCl 4 -induced liver fibrosis by activating autophagy signaling [ 105 ].…”
Section: Flavonoidsmentioning
confidence: 99%
“…Oroxylin A prevented from angiogenesis of LSECs in liver fibrosis via inhibition of the YAP/HIF-1 α signaling pathway [ 102 ]. Moreover, inhibition of glycolysis-dependent contraction via suppression of lactate dehydrogenase-A (LDH-A) and induction of apoptosis via endoplasmic reticulum (ER) stress in HSCs were involved in antihepatic fibrosis effects of oroxylin A [ 103 , 104 ]. Apart from these signaling pathways, oroxylin A also alleviated CCl 4 -induced liver fibrosis by activating autophagy signaling [ 105 ].…”
Section: Flavonoidsmentioning
confidence: 99%
“…The natural product oroxylin destroys aerobic glycolysis through LDH-A, inhibits the contraction of HSCs, and reduces liver fibrosis (18). The well-known natural product curcumin can also inhibit aerobic glycolysis by HSCs, the mechanism of which is related to the activation of adenosine monophosphate-activated protein kinase (19).…”
Section: Discussionmentioning
confidence: 99%
“…Activation of AMPK was required for curcumin blockade of HSC glycolysis [19]. All three rate-limiting enzymes of glycolysis (HK2, PFK1 and PKM2) were inhibited by oroxylin A in HSCs, resulting in the restriction of HSC contraction [20].…”
Section: Discussionmentioning
confidence: 99%